| Full name: NCK associated protein 1 | Alias Symbol: Nap1|HEM2|NAP125 | ||
| Type: protein-coding gene | Cytoband: 2q32.1 | ||
| Entrez ID: 10787 | HGNC ID: HGNC:7666 | Ensembl Gene: ENSG00000061676 | OMIM ID: 604891 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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NCKAP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
Expression of NCKAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NCKAP1 | 10787 | 207738_s_at | -0.0468 | 0.9163 | |
| GSE20347 | NCKAP1 | 10787 | 207738_s_at | -0.3392 | 0.0213 | |
| GSE23400 | NCKAP1 | 10787 | 207738_s_at | -0.1685 | 0.0040 | |
| GSE26886 | NCKAP1 | 10787 | 207738_s_at | -0.4128 | 0.0318 | |
| GSE29001 | NCKAP1 | 10787 | 207738_s_at | -0.2759 | 0.3948 | |
| GSE38129 | NCKAP1 | 10787 | 207738_s_at | -0.1972 | 0.0612 | |
| GSE45670 | NCKAP1 | 10787 | 207738_s_at | -0.2069 | 0.0645 | |
| GSE63941 | NCKAP1 | 10787 | 207738_s_at | -0.5820 | 0.0867 | |
| GSE77861 | NCKAP1 | 10787 | 207738_s_at | -0.3414 | 0.0377 | |
| GSE97050 | NCKAP1 | 10787 | A_23_P73239 | -0.4014 | 0.1711 | |
| SRP007169 | NCKAP1 | 10787 | RNAseq | -0.5143 | 0.0906 | |
| SRP008496 | NCKAP1 | 10787 | RNAseq | -0.4875 | 0.0020 | |
| SRP064894 | NCKAP1 | 10787 | RNAseq | -0.7249 | 0.0070 | |
| SRP133303 | NCKAP1 | 10787 | RNAseq | -0.0450 | 0.6925 | |
| SRP159526 | NCKAP1 | 10787 | RNAseq | -0.6000 | 0.0191 | |
| SRP193095 | NCKAP1 | 10787 | RNAseq | -0.4389 | 0.0029 | |
| SRP219564 | NCKAP1 | 10787 | RNAseq | -0.9759 | 0.0077 | |
| TCGA | NCKAP1 | 10787 | RNAseq | -0.0582 | 0.1581 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NCKAP1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of NCKAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NCKAP1 | 10787 | 5 | 1 | 24 | |
| GSE20123 | NCKAP1 | 10787 | 5 | 1 | 24 | |
| GSE43470 | NCKAP1 | 10787 | 5 | 1 | 37 | |
| GSE46452 | NCKAP1 | 10787 | 1 | 4 | 54 | |
| GSE47630 | NCKAP1 | 10787 | 4 | 4 | 32 | |
| GSE54993 | NCKAP1 | 10787 | 0 | 5 | 65 | |
| GSE54994 | NCKAP1 | 10787 | 12 | 5 | 36 | |
| GSE60625 | NCKAP1 | 10787 | 0 | 3 | 8 | |
| GSE74703 | NCKAP1 | 10787 | 4 | 1 | 31 | |
| GSE74704 | NCKAP1 | 10787 | 2 | 1 | 17 | |
| TCGA | NCKAP1 | 10787 | 27 | 8 | 61 |
Total number of gains: 65; Total number of losses: 34; Total Number of normals: 389.
Somatic mutations of NCKAP1:
Generating mutation plots.
Highly correlated genes for NCKAP1:
Showing top 20/703 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NCKAP1 | GPBP1 | 0.813119 | 3 | 0 | 3 |
| NCKAP1 | ZDHHC21 | 0.792058 | 3 | 0 | 3 |
| NCKAP1 | LNX2 | 0.790437 | 3 | 0 | 3 |
| NCKAP1 | MRFAP1L1 | 0.788978 | 3 | 0 | 3 |
| NCKAP1 | KDM3A | 0.765533 | 3 | 0 | 3 |
| NCKAP1 | ARFGEF2 | 0.764894 | 4 | 0 | 4 |
| NCKAP1 | ZNF92 | 0.762089 | 3 | 0 | 3 |
| NCKAP1 | SPCS2 | 0.760333 | 3 | 0 | 3 |
| NCKAP1 | NR2C2 | 0.756365 | 3 | 0 | 3 |
| NCKAP1 | RINT1 | 0.746085 | 4 | 0 | 4 |
| NCKAP1 | NDUFA10 | 0.744844 | 3 | 0 | 3 |
| NCKAP1 | PIK3R1 | 0.744177 | 3 | 0 | 3 |
| NCKAP1 | PCBD2 | 0.738934 | 3 | 0 | 3 |
| NCKAP1 | LNPEP | 0.736424 | 4 | 0 | 4 |
| NCKAP1 | RBKS | 0.73455 | 3 | 0 | 3 |
| NCKAP1 | GLUD1 | 0.733446 | 3 | 0 | 3 |
| NCKAP1 | VAPA | 0.727279 | 4 | 0 | 3 |
| NCKAP1 | RWDD4 | 0.726295 | 3 | 0 | 3 |
| NCKAP1 | PTRHD1 | 0.72349 | 3 | 0 | 3 |
| NCKAP1 | SCO1 | 0.722774 | 3 | 0 | 3 |
For details and further investigation, click here
