PDS5B

 

Full name: PDS5 cohesin associated factor B Alias Symbol: AS3|KIAA0979|FLJ23236|CG008
Type: protein-coding gene Cytoband: 13q13.1
Entrez ID: 23047 HGNC ID: HGNC:20418 Ensembl Gene: ENSG00000083642 OMIM ID: 605333
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 6/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PDS5B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PDS5B 23047 207956_x_at 0.3369 0.3647
GSE20347 PDS5B 23047 207956_x_at 0.3825 0.0531
GSE23400 PDS5B 23047 207956_x_at 0.4373 0.0000
GSE26886 PDS5B 23047 207956_x_at 1.4373 0.0000
GSE29001 PDS5B 23047 207956_x_at 0.7203 0.0429
GSE38129 PDS5B 23047 207956_x_at 0.3063 0.0806
GSE45670 PDS5B 23047 207956_x_at 0.0343 0.8895
GSE53622 PDS5B 23047 97383 -0.4732 0.0000
GSE53624 PDS5B 23047 97383 -0.3559 0.0000
GSE63941 PDS5B 23047 207956_x_at -0.0117 0.9862
GSE77861 PDS5B 23047 207956_x_at 0.5139 0.2494
GSE97050 PDS5B 23047 A_23_P205098 -0.4334 0.2217
SRP007169 PDS5B 23047 RNAseq 1.2390 0.0020
SRP008496 PDS5B 23047 RNAseq 1.4018 0.0000
SRP064894 PDS5B 23047 RNAseq 0.4115 0.0063
SRP133303 PDS5B 23047 RNAseq 0.0844 0.4771
SRP159526 PDS5B 23047 RNAseq -0.2446 0.2076
SRP193095 PDS5B 23047 RNAseq 0.0795 0.4654
SRP219564 PDS5B 23047 RNAseq -0.0757 0.8443
TCGA PDS5B 23047 RNAseq -0.0825 0.1225

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by PDS5B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PDS5B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PDS5B 23047 1 15 14
GSE20123 PDS5B 23047 1 14 15
GSE43470 PDS5B 23047 2 13 28
GSE46452 PDS5B 23047 0 33 26
GSE47630 PDS5B 23047 2 27 11
GSE54993 PDS5B 23047 12 2 56
GSE54994 PDS5B 23047 2 15 36
GSE60625 PDS5B 23047 0 3 8
GSE74703 PDS5B 23047 2 10 24
GSE74704 PDS5B 23047 0 12 8
TCGA PDS5B 23047 8 37 51

Total number of gains: 30; Total number of losses: 181; Total Number of normals: 277.  

 

Somatic mutations of PDS5B:

 

Generating mutation plots.

 

Highly correlated genes for PDS5B:

 

Showing top 20/1349 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PDS5BPIK3R10.796522303
PDS5BZNF710.791362303
PDS5BTYW30.771626303
PDS5BIGIP0.76223303
PDS5BMBD50.755878303
PDS5BANO50.755381303
PDS5BSMCR80.752185404
PDS5BTMED80.751568404
PDS5BTEAD40.751303303
PDS5BDNTTIP10.749174303
PDS5BPKIG0.747976505
PDS5BCYP2U10.746458404
PDS5BCELF20.74641303
PDS5BANAPC160.744231303
PDS5BGLRX50.738533505
PDS5BUTP14C0.734458404
PDS5BRGMB0.731325404
PDS5BFRMD30.729787303
PDS5BZNF2510.72745303
PDS5BNIPSNAP3B0.725908303

For details and further investigation, click here