| Full name: forkhead box O3 | Alias Symbol: AF6q21|FOXO2 | ||
| Type: protein-coding gene | Cytoband: 6q21 | ||
| Entrez ID: 2309 | HGNC ID: HGNC:3821 | Ensembl Gene: ENSG00000118689 | OMIM ID: 602681 |
| Drug and gene relationship at DGIdb | |||
FOXO3 involved pathways:
Expression of FOXO3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FOXO3 | 2309 | 224891_at | -0.7874 | 0.1386 | |
| GSE20347 | FOXO3 | 2309 | 204131_s_at | -0.1385 | 0.3374 | |
| GSE23400 | FOXO3 | 2309 | 204131_s_at | -0.2520 | 0.0014 | |
| GSE26886 | FOXO3 | 2309 | 224891_at | 0.0271 | 0.9038 | |
| GSE29001 | FOXO3 | 2309 | 204131_s_at | -0.3401 | 0.1725 | |
| GSE38129 | FOXO3 | 2309 | 204131_s_at | -0.2680 | 0.1976 | |
| GSE45670 | FOXO3 | 2309 | 224891_at | -0.6027 | 0.0000 | |
| GSE53622 | FOXO3 | 2309 | 8298 | -0.2909 | 0.0000 | |
| GSE53624 | FOXO3 | 2309 | 145127 | -0.6763 | 0.0000 | |
| GSE63941 | FOXO3 | 2309 | 224891_at | -1.0653 | 0.0150 | |
| GSE77861 | FOXO3 | 2309 | 224891_at | -0.2277 | 0.5036 | |
| GSE97050 | FOXO3 | 2309 | A_32_P102062 | -0.3306 | 0.1920 | |
| SRP007169 | FOXO3 | 2309 | RNAseq | -0.8515 | 0.0334 | |
| SRP008496 | FOXO3 | 2309 | RNAseq | -0.9391 | 0.0001 | |
| SRP064894 | FOXO3 | 2309 | RNAseq | -0.8155 | 0.0017 | |
| SRP133303 | FOXO3 | 2309 | RNAseq | -0.5071 | 0.0048 | |
| SRP159526 | FOXO3 | 2309 | RNAseq | -0.5390 | 0.0961 | |
| SRP193095 | FOXO3 | 2309 | RNAseq | -0.6443 | 0.0000 | |
| SRP219564 | FOXO3 | 2309 | RNAseq | -0.3432 | 0.2400 | |
| TCGA | FOXO3 | 2309 | RNAseq | -0.2735 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FOXO3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FOXO3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FOXO3 | 2309 | 3 | 3 | 24 | |
| GSE20123 | FOXO3 | 2309 | 3 | 2 | 25 | |
| GSE43470 | FOXO3 | 2309 | 3 | 1 | 39 | |
| GSE46452 | FOXO3 | 2309 | 2 | 11 | 46 | |
| GSE47630 | FOXO3 | 2309 | 9 | 4 | 27 | |
| GSE54993 | FOXO3 | 2309 | 3 | 2 | 65 | |
| GSE54994 | FOXO3 | 2309 | 9 | 8 | 36 | |
| GSE60625 | FOXO3 | 2309 | 0 | 2 | 9 | |
| GSE74703 | FOXO3 | 2309 | 2 | 1 | 33 | |
| GSE74704 | FOXO3 | 2309 | 1 | 0 | 19 | |
| TCGA | FOXO3 | 2309 | 6 | 24 | 66 |
Total number of gains: 41; Total number of losses: 58; Total Number of normals: 389.
Somatic mutations of FOXO3:
Generating mutation plots.
Highly correlated genes for FOXO3:
Showing top 20/646 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FOXO3 | PCMTD1 | 0.780631 | 4 | 0 | 4 |
| FOXO3 | PDCD4 | 0.764771 | 3 | 0 | 3 |
| FOXO3 | PIK3R1 | 0.753927 | 3 | 0 | 3 |
| FOXO3 | TMEM220 | 0.752663 | 4 | 0 | 4 |
| FOXO3 | NLGN4Y | 0.751479 | 3 | 0 | 3 |
| FOXO3 | CYP27A1 | 0.743278 | 4 | 0 | 4 |
| FOXO3 | LIFR | 0.733634 | 3 | 0 | 3 |
| FOXO3 | HDHD2 | 0.730719 | 4 | 0 | 4 |
| FOXO3 | RBM20 | 0.714908 | 4 | 0 | 3 |
| FOXO3 | USP16 | 0.714281 | 3 | 0 | 3 |
| FOXO3 | HNRNPA3 | 0.713478 | 4 | 0 | 4 |
| FOXO3 | SYNE1 | 0.710291 | 4 | 0 | 4 |
| FOXO3 | USP8 | 0.707315 | 3 | 0 | 3 |
| FOXO3 | HMGN3 | 0.706227 | 3 | 0 | 3 |
| FOXO3 | LYRM1 | 0.706168 | 3 | 0 | 3 |
| FOXO3 | FBXO9 | 0.704152 | 4 | 0 | 3 |
| FOXO3 | XPC | 0.699071 | 4 | 0 | 3 |
| FOXO3 | EIF1AX | 0.692536 | 3 | 0 | 3 |
| FOXO3 | ARHGAP31 | 0.686641 | 4 | 0 | 4 |
| FOXO3 | MRPS18C | 0.684915 | 3 | 0 | 3 |
For details and further investigation, click here
