| Full name: DNA polymerase kappa | Alias Symbol: POLQ|DINP | ||
| Type: protein-coding gene | Cytoband: 5q13.3 | ||
| Entrez ID: 51426 | HGNC ID: HGNC:9183 | Ensembl Gene: ENSG00000122008 | OMIM ID: 605650 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of POLK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLK | 51426 | 223261_at | -0.5468 | 0.3436 | |
| GSE26886 | POLK | 51426 | 223260_s_at | 0.0595 | 0.7835 | |
| GSE45670 | POLK | 51426 | 223261_at | -0.5652 | 0.0001 | |
| GSE53622 | POLK | 51426 | 23968 | -0.4443 | 0.0000 | |
| GSE53624 | POLK | 51426 | 149284 | -0.3087 | 0.0000 | |
| GSE63941 | POLK | 51426 | 223261_at | -0.5580 | 0.2887 | |
| GSE77861 | POLK | 51426 | 223260_s_at | 0.0216 | 0.9077 | |
| GSE97050 | POLK | 51426 | A_23_P386450 | -0.0854 | 0.6892 | |
| SRP007169 | POLK | 51426 | RNAseq | 0.8822 | 0.0619 | |
| SRP008496 | POLK | 51426 | RNAseq | 0.8382 | 0.0067 | |
| SRP064894 | POLK | 51426 | RNAseq | -0.1778 | 0.5235 | |
| SRP133303 | POLK | 51426 | RNAseq | -0.0651 | 0.6769 | |
| SRP159526 | POLK | 51426 | RNAseq | -0.3670 | 0.3387 | |
| SRP193095 | POLK | 51426 | RNAseq | -0.1239 | 0.1334 | |
| SRP219564 | POLK | 51426 | RNAseq | -0.1830 | 0.5845 | |
| TCGA | POLK | 51426 | RNAseq | -0.2032 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POLK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLK | 51426 | 1 | 13 | 16 | |
| GSE20123 | POLK | 51426 | 1 | 13 | 16 | |
| GSE43470 | POLK | 51426 | 1 | 13 | 29 | |
| GSE46452 | POLK | 51426 | 0 | 28 | 31 | |
| GSE47630 | POLK | 51426 | 1 | 19 | 20 | |
| GSE54993 | POLK | 51426 | 8 | 1 | 61 | |
| GSE54994 | POLK | 51426 | 1 | 19 | 33 | |
| GSE60625 | POLK | 51426 | 0 | 0 | 11 | |
| GSE74703 | POLK | 51426 | 1 | 9 | 26 | |
| GSE74704 | POLK | 51426 | 1 | 6 | 13 | |
| TCGA | POLK | 51426 | 3 | 51 | 42 |
Total number of gains: 18; Total number of losses: 172; Total Number of normals: 298.
Somatic mutations of POLK:
Generating mutation plots.
Highly correlated genes for POLK:
Showing top 20/561 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLK | LRCH3 | 0.824928 | 3 | 0 | 3 |
| POLK | RAPGEF2 | 0.746857 | 3 | 0 | 3 |
| POLK | SAP30L | 0.745162 | 3 | 0 | 3 |
| POLK | PIK3R1 | 0.743487 | 4 | 0 | 4 |
| POLK | TNFSF12 | 0.740293 | 3 | 0 | 3 |
| POLK | HERC1 | 0.737889 | 3 | 0 | 3 |
| POLK | FNBP1 | 0.730726 | 3 | 0 | 3 |
| POLK | TSHZ1 | 0.723528 | 3 | 0 | 3 |
| POLK | ITIH5 | 0.723438 | 3 | 0 | 3 |
| POLK | SEPSECS | 0.720992 | 3 | 0 | 3 |
| POLK | NR3C2 | 0.719488 | 3 | 0 | 3 |
| POLK | RNF146 | 0.719039 | 4 | 0 | 4 |
| POLK | ZBTB16 | 0.717619 | 3 | 0 | 3 |
| POLK | RNLS | 0.716335 | 3 | 0 | 3 |
| POLK | ZNF615 | 0.715206 | 4 | 0 | 4 |
| POLK | NSA2 | 0.713679 | 6 | 0 | 6 |
| POLK | ST6GALNAC6 | 0.712805 | 3 | 0 | 3 |
| POLK | BTF3 | 0.711671 | 4 | 0 | 3 |
| POLK | GAB1 | 0.710409 | 3 | 0 | 3 |
| POLK | GIMAP1 | 0.706331 | 4 | 0 | 4 |
For details and further investigation, click here
