| Full name: endoplasmic reticulum to nucleus signaling 1 | Alias Symbol: IRE1|IRE1P | ||
| Type: protein-coding gene | Cytoband: 17q23.3 | ||
| Entrez ID: 2081 | HGNC ID: HGNC:3449 | Ensembl Gene: ENSG00000178607 | OMIM ID: 604033 |
| Drug and gene relationship at DGIdb | |||
ERN1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis | |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | |
| hsa05010 | Alzheimer's disease |
Expression of ERN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERN1 | 2081 | 227755_at | -0.0568 | 0.9352 | |
| GSE20347 | ERN1 | 2081 | 207061_at | -0.0477 | 0.6890 | |
| GSE23400 | ERN1 | 2081 | 207061_at | -0.1423 | 0.0000 | |
| GSE26886 | ERN1 | 2081 | 227755_at | -0.8508 | 0.0005 | |
| GSE29001 | ERN1 | 2081 | 207061_at | -0.0294 | 0.8623 | |
| GSE38129 | ERN1 | 2081 | 207061_at | -0.1721 | 0.0506 | |
| GSE45670 | ERN1 | 2081 | 227755_at | -0.0403 | 0.8406 | |
| GSE53622 | ERN1 | 2081 | 108719 | -0.4781 | 0.0000 | |
| GSE53624 | ERN1 | 2081 | 108719 | -0.4659 | 0.0000 | |
| GSE63941 | ERN1 | 2081 | 227755_at | -0.6088 | 0.5047 | |
| GSE77861 | ERN1 | 2081 | 227755_at | 0.0101 | 0.9794 | |
| GSE97050 | ERN1 | 2081 | A_23_P164042 | 0.2737 | 0.4628 | |
| SRP007169 | ERN1 | 2081 | RNAseq | -0.3392 | 0.4700 | |
| SRP008496 | ERN1 | 2081 | RNAseq | -0.2370 | 0.4819 | |
| SRP064894 | ERN1 | 2081 | RNAseq | -0.3126 | 0.2929 | |
| SRP133303 | ERN1 | 2081 | RNAseq | -0.1897 | 0.2318 | |
| SRP159526 | ERN1 | 2081 | RNAseq | -0.7352 | 0.0614 | |
| SRP193095 | ERN1 | 2081 | RNAseq | -0.1144 | 0.5160 | |
| SRP219564 | ERN1 | 2081 | RNAseq | -0.0827 | 0.8740 | |
| TCGA | ERN1 | 2081 | RNAseq | -0.5841 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ERN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ERN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERN1 | 2081 | 3 | 1 | 26 | |
| GSE20123 | ERN1 | 2081 | 3 | 1 | 26 | |
| GSE43470 | ERN1 | 2081 | 4 | 0 | 39 | |
| GSE46452 | ERN1 | 2081 | 32 | 0 | 27 | |
| GSE47630 | ERN1 | 2081 | 7 | 1 | 32 | |
| GSE54993 | ERN1 | 2081 | 2 | 5 | 63 | |
| GSE54994 | ERN1 | 2081 | 9 | 4 | 40 | |
| GSE60625 | ERN1 | 2081 | 4 | 0 | 7 | |
| GSE74703 | ERN1 | 2081 | 4 | 0 | 32 | |
| GSE74704 | ERN1 | 2081 | 3 | 1 | 16 | |
| TCGA | ERN1 | 2081 | 30 | 8 | 58 |
Total number of gains: 101; Total number of losses: 21; Total Number of normals: 366.
Somatic mutations of ERN1:
Generating mutation plots.
Highly correlated genes for ERN1:
Showing top 20/412 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERN1 | HECW1 | 0.823748 | 4 | 0 | 4 |
| ERN1 | CNTD2 | 0.795793 | 4 | 0 | 4 |
| ERN1 | KIR3DL3 | 0.79507 | 4 | 0 | 4 |
| ERN1 | DAB1 | 0.784026 | 4 | 0 | 4 |
| ERN1 | LMAN1L | 0.782431 | 4 | 0 | 4 |
| ERN1 | PRAMEF12 | 0.780519 | 4 | 0 | 4 |
| ERN1 | MEFV | 0.776908 | 3 | 0 | 3 |
| ERN1 | PGC | 0.759912 | 3 | 0 | 3 |
| ERN1 | PKD2L1 | 0.75924 | 3 | 0 | 3 |
| ERN1 | OR6A2 | 0.758776 | 3 | 0 | 3 |
| ERN1 | PRODH2 | 0.755924 | 4 | 0 | 4 |
| ERN1 | C4BPA | 0.752175 | 4 | 0 | 4 |
| ERN1 | SLC30A3 | 0.744842 | 4 | 0 | 4 |
| ERN1 | RNF17 | 0.735158 | 4 | 0 | 4 |
| ERN1 | CYP2D6 | 0.729342 | 5 | 0 | 4 |
| ERN1 | RFPL3 | 0.728819 | 3 | 0 | 3 |
| ERN1 | GRM4 | 0.723975 | 4 | 0 | 4 |
| ERN1 | CCZ1 | 0.723385 | 3 | 0 | 3 |
| ERN1 | SLC5A4 | 0.722907 | 5 | 0 | 5 |
| ERN1 | OR52A1 | 0.71937 | 3 | 0 | 3 |
For details and further investigation, click here
