| Full name: eukaryotic translation initiation factor 3 subunit L | Alias Symbol: HSPC021|HSPC025|EIF3S11 | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 51386 | HGNC ID: HGNC:18138 | Ensembl Gene: ENSG00000100129 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EIF3L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF3L | 51386 | 217719_at | -0.2338 | 0.3413 | |
| GSE20347 | EIF3L | 51386 | 217719_at | -0.2502 | 0.0213 | |
| GSE23400 | EIF3L | 51386 | 217719_at | -0.1963 | 0.0104 | |
| GSE26886 | EIF3L | 51386 | 217719_at | 0.4763 | 0.0002 | |
| GSE29001 | EIF3L | 51386 | 217719_at | -0.2657 | 0.1367 | |
| GSE38129 | EIF3L | 51386 | 217719_at | -0.3036 | 0.0006 | |
| GSE45670 | EIF3L | 51386 | 217719_at | -0.4688 | 0.0001 | |
| GSE53622 | EIF3L | 51386 | 63906 | -0.5054 | 0.0000 | |
| GSE53624 | EIF3L | 51386 | 63906 | -0.3872 | 0.0000 | |
| GSE63941 | EIF3L | 51386 | 217719_at | 0.1147 | 0.7006 | |
| GSE77861 | EIF3L | 51386 | 217719_at | -0.1251 | 0.6367 | |
| GSE97050 | EIF3L | 51386 | A_23_P57521 | -0.3110 | 0.2204 | |
| SRP007169 | EIF3L | 51386 | RNAseq | -0.6225 | 0.0347 | |
| SRP008496 | EIF3L | 51386 | RNAseq | -0.6073 | 0.0011 | |
| SRP064894 | EIF3L | 51386 | RNAseq | -0.4353 | 0.0306 | |
| SRP133303 | EIF3L | 51386 | RNAseq | -0.7158 | 0.0000 | |
| SRP159526 | EIF3L | 51386 | RNAseq | -0.5200 | 0.0077 | |
| SRP193095 | EIF3L | 51386 | RNAseq | -0.8845 | 0.0000 | |
| SRP219564 | EIF3L | 51386 | RNAseq | -0.5757 | 0.0139 | |
| TCGA | EIF3L | 51386 | RNAseq | -0.1355 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EIF3L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF3L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF3L | 51386 | 6 | 5 | 19 | |
| GSE20123 | EIF3L | 51386 | 6 | 4 | 20 | |
| GSE43470 | EIF3L | 51386 | 5 | 6 | 32 | |
| GSE46452 | EIF3L | 51386 | 32 | 2 | 25 | |
| GSE47630 | EIF3L | 51386 | 9 | 4 | 27 | |
| GSE54993 | EIF3L | 51386 | 3 | 6 | 61 | |
| GSE54994 | EIF3L | 51386 | 9 | 8 | 36 | |
| GSE60625 | EIF3L | 51386 | 5 | 0 | 6 | |
| GSE74703 | EIF3L | 51386 | 5 | 4 | 27 | |
| GSE74704 | EIF3L | 51386 | 3 | 2 | 15 | |
| TCGA | EIF3L | 51386 | 27 | 15 | 54 |
Total number of gains: 110; Total number of losses: 56; Total Number of normals: 322.
Somatic mutations of EIF3L:
Generating mutation plots.
Highly correlated genes for EIF3L:
Showing top 20/569 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF3L | PMPCB | 0.788331 | 3 | 0 | 3 |
| EIF3L | GNPAT | 0.781378 | 3 | 0 | 3 |
| EIF3L | FGF7 | 0.770441 | 3 | 0 | 3 |
| EIF3L | CLDND2 | 0.768483 | 3 | 0 | 3 |
| EIF3L | C11orf74 | 0.764322 | 3 | 0 | 3 |
| EIF3L | ANAPC10 | 0.762082 | 3 | 0 | 3 |
| EIF3L | LY75 | 0.760512 | 3 | 0 | 3 |
| EIF3L | TEAD2 | 0.757198 | 3 | 0 | 3 |
| EIF3L | ANO6 | 0.750623 | 3 | 0 | 3 |
| EIF3L | ZNF791 | 0.750283 | 3 | 0 | 3 |
| EIF3L | NFIL3 | 0.748677 | 3 | 0 | 3 |
| EIF3L | SIN3A | 0.74687 | 3 | 0 | 3 |
| EIF3L | FIBIN | 0.743375 | 3 | 0 | 3 |
| EIF3L | TPK1 | 0.731238 | 3 | 0 | 3 |
| EIF3L | JMJD4 | 0.728187 | 3 | 0 | 3 |
| EIF3L | FAM13A | 0.724077 | 3 | 0 | 3 |
| EIF3L | ARHGEF6 | 0.721951 | 4 | 0 | 4 |
| EIF3L | C9orf72 | 0.71814 | 3 | 0 | 3 |
| EIF3L | ATP11C | 0.718034 | 3 | 0 | 3 |
| EIF3L | ZNF207 | 0.714349 | 3 | 0 | 3 |
For details and further investigation, click here
