| Full name: NIMA related kinase 7 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q31.3 | ||
| Entrez ID: 140609 | HGNC ID: HGNC:13386 | Ensembl Gene: ENSG00000151414 | OMIM ID: 606848 |
| Drug and gene relationship at DGIdb | |||
Expression of NEK7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEK7 | 140609 | 212530_at | -0.1032 | 0.8999 | |
| GSE20347 | NEK7 | 140609 | 212530_at | 0.2298 | 0.2431 | |
| GSE23400 | NEK7 | 140609 | 212530_at | 0.2656 | 0.0670 | |
| GSE26886 | NEK7 | 140609 | 212530_at | 0.6597 | 0.0123 | |
| GSE29001 | NEK7 | 140609 | 212530_at | 0.7589 | 0.2764 | |
| GSE38129 | NEK7 | 140609 | 212530_at | -0.0981 | 0.5904 | |
| GSE45670 | NEK7 | 140609 | 212530_at | -0.1395 | 0.5860 | |
| GSE53622 | NEK7 | 140609 | 106693 | -0.0181 | 0.8609 | |
| GSE53624 | NEK7 | 140609 | 106693 | 0.0363 | 0.5556 | |
| GSE63941 | NEK7 | 140609 | 212530_at | -1.5102 | 0.0253 | |
| GSE77861 | NEK7 | 140609 | 212530_at | 0.3288 | 0.3412 | |
| GSE97050 | NEK7 | 140609 | A_23_P353574 | -0.2627 | 0.2858 | |
| SRP007169 | NEK7 | 140609 | RNAseq | -0.1852 | 0.6548 | |
| SRP008496 | NEK7 | 140609 | RNAseq | -0.2071 | 0.4048 | |
| SRP064894 | NEK7 | 140609 | RNAseq | -0.1931 | 0.5347 | |
| SRP133303 | NEK7 | 140609 | RNAseq | 0.3482 | 0.0864 | |
| SRP159526 | NEK7 | 140609 | RNAseq | -0.1938 | 0.5634 | |
| SRP193095 | NEK7 | 140609 | RNAseq | 0.2033 | 0.2846 | |
| SRP219564 | NEK7 | 140609 | RNAseq | -0.3264 | 0.2977 | |
| TCGA | NEK7 | 140609 | RNAseq | -0.0591 | 0.2674 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NEK7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEK7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEK7 | 140609 | 7 | 0 | 23 | |
| GSE20123 | NEK7 | 140609 | 7 | 0 | 23 | |
| GSE43470 | NEK7 | 140609 | 7 | 0 | 36 | |
| GSE46452 | NEK7 | 140609 | 3 | 1 | 55 | |
| GSE47630 | NEK7 | 140609 | 14 | 0 | 26 | |
| GSE54993 | NEK7 | 140609 | 0 | 6 | 64 | |
| GSE54994 | NEK7 | 140609 | 15 | 1 | 37 | |
| GSE60625 | NEK7 | 140609 | 0 | 0 | 11 | |
| GSE74703 | NEK7 | 140609 | 7 | 0 | 29 | |
| GSE74704 | NEK7 | 140609 | 2 | 0 | 18 | |
| TCGA | NEK7 | 140609 | 43 | 5 | 48 |
Total number of gains: 105; Total number of losses: 13; Total Number of normals: 370.
Somatic mutations of NEK7:
Generating mutation plots.
Highly correlated genes for NEK7:
Showing top 20/722 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEK7 | TMEM181 | 0.794993 | 3 | 0 | 3 |
| NEK7 | BBS9 | 0.789515 | 3 | 0 | 3 |
| NEK7 | PMPCB | 0.786655 | 3 | 0 | 3 |
| NEK7 | PCM1 | 0.784035 | 3 | 0 | 3 |
| NEK7 | DOCK7 | 0.762535 | 5 | 0 | 5 |
| NEK7 | ZMPSTE24 | 0.758238 | 3 | 0 | 3 |
| NEK7 | NDUFAF2 | 0.757025 | 3 | 0 | 3 |
| NEK7 | CCAR1 | 0.750825 | 3 | 0 | 3 |
| NEK7 | MMRN1 | 0.746988 | 3 | 0 | 3 |
| NEK7 | ZFP90 | 0.736065 | 3 | 0 | 3 |
| NEK7 | RPE | 0.733473 | 3 | 0 | 3 |
| NEK7 | SPIRE1 | 0.727718 | 3 | 0 | 3 |
| NEK7 | PPP1R21 | 0.726582 | 4 | 0 | 4 |
| NEK7 | SMCR8 | 0.725694 | 3 | 0 | 3 |
| NEK7 | TTC8 | 0.724385 | 4 | 0 | 3 |
| NEK7 | ZNF805 | 0.722227 | 3 | 0 | 3 |
| NEK7 | FAM13A | 0.71883 | 3 | 0 | 3 |
| NEK7 | SDR39U1 | 0.712923 | 3 | 0 | 3 |
| NEK7 | DNAJC13 | 0.709606 | 3 | 0 | 3 |
| NEK7 | PPP2R3A | 0.708605 | 3 | 0 | 3 |
For details and further investigation, click here
