| Full name: T cell lymphoma invasion and metastasis 2 | Alias Symbol: STEF | ||
| Type: protein-coding gene | Cytoband: 6q25.2-q25.3 | ||
| Entrez ID: 26230 | HGNC ID: HGNC:11806 | Ensembl Gene: ENSG00000146426 | OMIM ID: 604709 |
| Drug and gene relationship at DGIdb | |||
Expression of TIAM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TIAM2 | 26230 | 227866_at | -0.0967 | 0.8826 | |
| GSE20347 | TIAM2 | 26230 | 219950_s_at | -0.0103 | 0.9176 | |
| GSE23400 | TIAM2 | 26230 | 219950_s_at | -0.1195 | 0.0131 | |
| GSE26886 | TIAM2 | 26230 | 227866_at | 0.7659 | 0.0132 | |
| GSE29001 | TIAM2 | 26230 | 219950_s_at | -0.1898 | 0.2400 | |
| GSE38129 | TIAM2 | 26230 | 219950_s_at | -0.0244 | 0.7924 | |
| GSE45670 | TIAM2 | 26230 | 227866_at | 0.1073 | 0.6998 | |
| GSE53622 | TIAM2 | 26230 | 104863 | 0.3047 | 0.0382 | |
| GSE53624 | TIAM2 | 26230 | 104863 | 0.5514 | 0.0000 | |
| GSE63941 | TIAM2 | 26230 | 227866_at | 0.2572 | 0.6909 | |
| GSE77861 | TIAM2 | 26230 | 227866_at | 0.2951 | 0.2571 | |
| GSE97050 | TIAM2 | 26230 | A_24_P303454 | -0.0843 | 0.7260 | |
| SRP007169 | TIAM2 | 26230 | RNAseq | 1.7749 | 0.0495 | |
| SRP133303 | TIAM2 | 26230 | RNAseq | -0.1075 | 0.4822 | |
| SRP193095 | TIAM2 | 26230 | RNAseq | 0.3533 | 0.1839 | |
| SRP219564 | TIAM2 | 26230 | RNAseq | 0.3429 | 0.4483 | |
| TCGA | TIAM2 | 26230 | RNAseq | -0.2518 | 0.1294 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TIAM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TIAM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TIAM2 | 26230 | 1 | 4 | 25 | |
| GSE20123 | TIAM2 | 26230 | 1 | 3 | 26 | |
| GSE43470 | TIAM2 | 26230 | 4 | 0 | 39 | |
| GSE46452 | TIAM2 | 26230 | 3 | 10 | 46 | |
| GSE47630 | TIAM2 | 26230 | 9 | 4 | 27 | |
| GSE54993 | TIAM2 | 26230 | 3 | 2 | 65 | |
| GSE54994 | TIAM2 | 26230 | 8 | 8 | 37 | |
| GSE60625 | TIAM2 | 26230 | 0 | 1 | 10 | |
| GSE74703 | TIAM2 | 26230 | 4 | 0 | 32 | |
| GSE74704 | TIAM2 | 26230 | 0 | 1 | 19 | |
| TCGA | TIAM2 | 26230 | 12 | 22 | 62 |
Total number of gains: 45; Total number of losses: 55; Total Number of normals: 388.
Somatic mutations of TIAM2:
Generating mutation plots.
Highly correlated genes for TIAM2:
Showing top 20/272 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TIAM2 | PMPCB | 0.759313 | 3 | 0 | 3 |
| TIAM2 | POLA1 | 0.736819 | 3 | 0 | 3 |
| TIAM2 | RIMKLB | 0.724361 | 3 | 0 | 3 |
| TIAM2 | SAT2 | 0.713385 | 3 | 0 | 3 |
| TIAM2 | TGS1 | 0.697164 | 3 | 0 | 3 |
| TIAM2 | NIPA1 | 0.687657 | 3 | 0 | 3 |
| TIAM2 | TMF1 | 0.676816 | 4 | 0 | 3 |
| TIAM2 | FAM13C | 0.673328 | 3 | 0 | 3 |
| TIAM2 | ZXDA | 0.671534 | 3 | 0 | 3 |
| TIAM2 | TEX9 | 0.671142 | 3 | 0 | 3 |
| TIAM2 | DBP | 0.671059 | 3 | 0 | 3 |
| TIAM2 | KCNE3 | 0.667687 | 4 | 0 | 3 |
| TIAM2 | NSMCE4A | 0.65696 | 3 | 0 | 3 |
| TIAM2 | TMPO | 0.655683 | 3 | 0 | 3 |
| TIAM2 | FMO3 | 0.654234 | 3 | 0 | 3 |
| TIAM2 | SNX27 | 0.636624 | 5 | 0 | 3 |
| TIAM2 | SAG | 0.63653 | 5 | 0 | 4 |
| TIAM2 | RGMB | 0.636399 | 3 | 0 | 3 |
| TIAM2 | EPC2 | 0.634308 | 5 | 0 | 4 |
| TIAM2 | MUS81 | 0.633301 | 3 | 0 | 3 |
For details and further investigation, click here
