| Full name: syntaxin binding protein 4 | Alias Symbol: Synip|MGC50337 | ||
| Type: protein-coding gene | Cytoband: 17q22 | ||
| Entrez ID: 252983 | HGNC ID: HGNC:19694 | Ensembl Gene: ENSG00000166263 | OMIM ID: 610415 |
| Drug and gene relationship at DGIdb | |||
Expression of STXBP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STXBP4 | 252983 | 237706_at | 0.0706 | 0.8525 | |
| GSE26886 | STXBP4 | 252983 | 237706_at | 0.5242 | 0.0002 | |
| GSE45670 | STXBP4 | 252983 | 244404_at | -0.0390 | 0.8607 | |
| GSE53622 | STXBP4 | 252983 | 41800 | 0.3505 | 0.0001 | |
| GSE53624 | STXBP4 | 252983 | 135889 | 0.5759 | 0.0000 | |
| GSE63941 | STXBP4 | 252983 | 237706_at | -0.8744 | 0.0007 | |
| GSE77861 | STXBP4 | 252983 | 244404_at | -0.0813 | 0.4272 | |
| GSE97050 | STXBP4 | 252983 | A_23_P375566 | 0.0983 | 0.7124 | |
| SRP007169 | STXBP4 | 252983 | RNAseq | 1.4874 | 0.0023 | |
| SRP008496 | STXBP4 | 252983 | RNAseq | 1.6614 | 0.0000 | |
| SRP064894 | STXBP4 | 252983 | RNAseq | 0.5185 | 0.0063 | |
| SRP133303 | STXBP4 | 252983 | RNAseq | 0.7426 | 0.0015 | |
| SRP159526 | STXBP4 | 252983 | RNAseq | 0.7755 | 0.0165 | |
| SRP193095 | STXBP4 | 252983 | RNAseq | 0.2000 | 0.0168 | |
| SRP219564 | STXBP4 | 252983 | RNAseq | 0.2351 | 0.4877 | |
| TCGA | STXBP4 | 252983 | RNAseq | -0.1817 | 0.0326 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by STXBP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STXBP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STXBP4 | 252983 | 4 | 1 | 25 | |
| GSE20123 | STXBP4 | 252983 | 4 | 1 | 25 | |
| GSE43470 | STXBP4 | 252983 | 2 | 1 | 40 | |
| GSE46452 | STXBP4 | 252983 | 32 | 0 | 27 | |
| GSE47630 | STXBP4 | 252983 | 7 | 1 | 32 | |
| GSE54993 | STXBP4 | 252983 | 2 | 4 | 64 | |
| GSE54994 | STXBP4 | 252983 | 9 | 5 | 39 | |
| GSE60625 | STXBP4 | 252983 | 4 | 0 | 7 | |
| GSE74703 | STXBP4 | 252983 | 2 | 1 | 33 | |
| GSE74704 | STXBP4 | 252983 | 3 | 1 | 16 | |
| TCGA | STXBP4 | 252983 | 27 | 7 | 62 |
Total number of gains: 96; Total number of losses: 22; Total Number of normals: 370.
Somatic mutations of STXBP4:
Generating mutation plots.
Highly correlated genes for STXBP4:
Showing top 20/328 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STXBP4 | PMPCB | 0.803502 | 3 | 0 | 3 |
| STXBP4 | PLEKHO2 | 0.778175 | 3 | 0 | 3 |
| STXBP4 | DHX40 | 0.759136 | 3 | 0 | 3 |
| STXBP4 | C11orf96 | 0.754934 | 3 | 0 | 3 |
| STXBP4 | A1BG | 0.746845 | 3 | 0 | 3 |
| STXBP4 | MAP1A | 0.744391 | 3 | 0 | 3 |
| STXBP4 | PRPH2 | 0.740431 | 3 | 0 | 3 |
| STXBP4 | ZNF23 | 0.738682 | 3 | 0 | 3 |
| STXBP4 | NFIL3 | 0.738423 | 3 | 0 | 3 |
| STXBP4 | ZNF334 | 0.737841 | 3 | 0 | 3 |
| STXBP4 | SCMH1 | 0.733649 | 3 | 0 | 3 |
| STXBP4 | RAPGEF2 | 0.731884 | 3 | 0 | 3 |
| STXBP4 | PNKD | 0.726135 | 3 | 0 | 3 |
| STXBP4 | STARD3NL | 0.726099 | 4 | 0 | 3 |
| STXBP4 | FIBIN | 0.723217 | 3 | 0 | 3 |
| STXBP4 | TNFSF4 | 0.721177 | 3 | 0 | 3 |
| STXBP4 | PLIN2 | 0.718298 | 3 | 0 | 3 |
| STXBP4 | CEP112 | 0.714673 | 4 | 0 | 4 |
| STXBP4 | UNC5C | 0.714135 | 3 | 0 | 3 |
| STXBP4 | PSEN2 | 0.710112 | 3 | 0 | 3 |
For details and further investigation, click here
