| Full name: protein phosphatase 4 catalytic subunit | Alias Symbol: PP4|PPX | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 5531 | HGNC ID: HGNC:9319 | Ensembl Gene: ENSG00000149923 | OMIM ID: 602035 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PPP4C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04922 | Glucagon signaling pathway |
Expression of PPP4C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP4C | 5531 | 208932_at | 0.2808 | 0.6483 | |
| GSE20347 | PPP4C | 5531 | 208932_at | -0.1817 | 0.1146 | |
| GSE23400 | PPP4C | 5531 | 208932_at | 0.0423 | 0.5228 | |
| GSE26886 | PPP4C | 5531 | 208932_at | -1.1174 | 0.0019 | |
| GSE29001 | PPP4C | 5531 | 208932_at | -0.1463 | 0.5853 | |
| GSE38129 | PPP4C | 5531 | 208932_at | 0.2279 | 0.1269 | |
| GSE45670 | PPP4C | 5531 | 208932_at | 0.0991 | 0.4621 | |
| GSE53622 | PPP4C | 5531 | 61393 | -0.0257 | 0.7615 | |
| GSE53624 | PPP4C | 5531 | 61393 | 0.0994 | 0.1591 | |
| GSE63941 | PPP4C | 5531 | 208932_at | 2.3680 | 0.0000 | |
| GSE77861 | PPP4C | 5531 | 208932_at | 0.0509 | 0.8151 | |
| GSE97050 | PPP4C | 5531 | A_23_P100355 | 0.4682 | 0.2722 | |
| SRP007169 | PPP4C | 5531 | RNAseq | -1.2181 | 0.0007 | |
| SRP008496 | PPP4C | 5531 | RNAseq | -1.0360 | 0.0000 | |
| SRP064894 | PPP4C | 5531 | RNAseq | -0.0223 | 0.9297 | |
| SRP133303 | PPP4C | 5531 | RNAseq | 0.2200 | 0.2125 | |
| SRP159526 | PPP4C | 5531 | RNAseq | -0.1213 | 0.6025 | |
| SRP193095 | PPP4C | 5531 | RNAseq | -0.2559 | 0.0185 | |
| SRP219564 | PPP4C | 5531 | RNAseq | -0.1816 | 0.5808 | |
| TCGA | PPP4C | 5531 | RNAseq | 0.2191 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by PPP4C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP4C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP4C | 5531 | 5 | 5 | 20 | |
| GSE20123 | PPP4C | 5531 | 5 | 4 | 21 | |
| GSE43470 | PPP4C | 5531 | 3 | 3 | 37 | |
| GSE46452 | PPP4C | 5531 | 38 | 1 | 20 | |
| GSE47630 | PPP4C | 5531 | 11 | 7 | 22 | |
| GSE54993 | PPP4C | 5531 | 2 | 5 | 63 | |
| GSE54994 | PPP4C | 5531 | 5 | 9 | 39 | |
| GSE60625 | PPP4C | 5531 | 4 | 0 | 7 | |
| GSE74703 | PPP4C | 5531 | 3 | 2 | 31 | |
| GSE74704 | PPP4C | 5531 | 3 | 2 | 15 | |
| TCGA | PPP4C | 5531 | 20 | 11 | 65 |
Total number of gains: 99; Total number of losses: 49; Total Number of normals: 340.
Somatic mutations of PPP4C:
Generating mutation plots.
Highly correlated genes for PPP4C:
Showing top 20/811 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP4C | E2F2 | 0.790141 | 4 | 0 | 4 |
| PPP4C | IRX3 | 0.768857 | 3 | 0 | 3 |
| PPP4C | SRSF9 | 0.745296 | 3 | 0 | 3 |
| PPP4C | RAB4B | 0.734884 | 3 | 0 | 3 |
| PPP4C | RPS3 | 0.73257 | 3 | 0 | 3 |
| PPP4C | SLC25A39 | 0.731613 | 8 | 0 | 8 |
| PPP4C | RNF149 | 0.729311 | 3 | 0 | 3 |
| PPP4C | RECQL5 | 0.725326 | 4 | 0 | 4 |
| PPP4C | FAM83G | 0.723379 | 3 | 0 | 3 |
| PPP4C | ESPN | 0.72267 | 3 | 0 | 3 |
| PPP4C | DNAJC9 | 0.722162 | 4 | 0 | 4 |
| PPP4C | ZNF101 | 0.719192 | 3 | 0 | 3 |
| PPP4C | KIAA1522 | 0.717584 | 5 | 0 | 4 |
| PPP4C | NDOR1 | 0.716428 | 3 | 0 | 3 |
| PPP4C | STON2 | 0.715664 | 3 | 0 | 3 |
| PPP4C | B3GNT5 | 0.714073 | 4 | 0 | 4 |
| PPP4C | TSTD1 | 0.710307 | 3 | 0 | 3 |
| PPP4C | KRTCAP3 | 0.708821 | 3 | 0 | 3 |
| PPP4C | IL2RG | 0.706268 | 3 | 0 | 3 |
| PPP4C | POLA1 | 0.70564 | 3 | 0 | 3 |
For details and further investigation, click here
