| Full name: iroquois homeobox 3 | Alias Symbol: IRX-1 | ||
| Type: protein-coding gene | Cytoband: 16q12.2 | ||
| Entrez ID: 79191 | HGNC ID: HGNC:14360 | Ensembl Gene: ENSG00000177508 | OMIM ID: 612985 |
| Drug and gene relationship at DGIdb | |||
Expression of IRX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRX3 | 79191 | 229638_at | 0.0920 | 0.9409 | |
| GSE26886 | IRX3 | 79191 | 229638_at | -0.3514 | 0.4521 | |
| GSE45670 | IRX3 | 79191 | 229638_at | 0.1847 | 0.4638 | |
| GSE53622 | IRX3 | 79191 | 18611 | -0.2653 | 0.2762 | |
| GSE53624 | IRX3 | 79191 | 18611 | -0.6811 | 0.0000 | |
| GSE63941 | IRX3 | 79191 | 229638_at | 2.8192 | 0.0015 | |
| GSE77861 | IRX3 | 79191 | 229638_at | -0.8433 | 0.0108 | |
| GSE97050 | IRX3 | 79191 | A_23_P152235 | 0.3223 | 0.7069 | |
| SRP007169 | IRX3 | 79191 | RNAseq | -1.7834 | 0.0029 | |
| SRP008496 | IRX3 | 79191 | RNAseq | -2.2963 | 0.0000 | |
| SRP064894 | IRX3 | 79191 | RNAseq | -0.3046 | 0.3752 | |
| SRP133303 | IRX3 | 79191 | RNAseq | -0.2568 | 0.4381 | |
| SRP159526 | IRX3 | 79191 | RNAseq | -0.4689 | 0.4221 | |
| SRP193095 | IRX3 | 79191 | RNAseq | -0.3615 | 0.2090 | |
| SRP219564 | IRX3 | 79191 | RNAseq | 0.4581 | 0.6575 | |
| TCGA | IRX3 | 79191 | RNAseq | 0.3300 | 0.0106 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by IRX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IRX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRX3 | 79191 | 3 | 0 | 27 | |
| GSE20123 | IRX3 | 79191 | 3 | 0 | 27 | |
| GSE43470 | IRX3 | 79191 | 2 | 7 | 34 | |
| GSE46452 | IRX3 | 79191 | 38 | 1 | 20 | |
| GSE47630 | IRX3 | 79191 | 11 | 7 | 22 | |
| GSE54993 | IRX3 | 79191 | 2 | 5 | 63 | |
| GSE54994 | IRX3 | 79191 | 7 | 10 | 36 | |
| GSE60625 | IRX3 | 79191 | 4 | 0 | 7 | |
| GSE74703 | IRX3 | 79191 | 2 | 4 | 30 | |
| GSE74704 | IRX3 | 79191 | 3 | 0 | 17 | |
| TCGA | IRX3 | 79191 | 26 | 11 | 59 |
Total number of gains: 101; Total number of losses: 45; Total Number of normals: 342.
Somatic mutations of IRX3:
Generating mutation plots.
Highly correlated genes for IRX3:
Showing top 20/472 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRX3 | ZNF165 | 0.811958 | 3 | 0 | 3 |
| IRX3 | AP1M2 | 0.78604 | 3 | 0 | 3 |
| IRX3 | GALNT3 | 0.780355 | 3 | 0 | 3 |
| IRX3 | ARPC3 | 0.772053 | 4 | 0 | 4 |
| IRX3 | PPP4C | 0.768857 | 3 | 0 | 3 |
| IRX3 | AP1S3 | 0.763187 | 3 | 0 | 3 |
| IRX3 | SYNE2 | 0.759108 | 3 | 0 | 3 |
| IRX3 | MPZL2 | 0.737865 | 4 | 0 | 4 |
| IRX3 | SPIC | 0.732736 | 3 | 0 | 3 |
| IRX3 | EPB41L5 | 0.731701 | 4 | 0 | 4 |
| IRX3 | TADA1 | 0.73064 | 3 | 0 | 3 |
| IRX3 | SNW1 | 0.730117 | 3 | 0 | 3 |
| IRX3 | KCTD1 | 0.727044 | 3 | 0 | 3 |
| IRX3 | LSR | 0.724884 | 3 | 0 | 3 |
| IRX3 | RBM20 | 0.719809 | 3 | 0 | 3 |
| IRX3 | SPINT2 | 0.718601 | 4 | 0 | 4 |
| IRX3 | NDFIP2 | 0.714981 | 3 | 0 | 3 |
| IRX3 | LIMK2 | 0.714127 | 3 | 0 | 3 |
| IRX3 | GTPBP2 | 0.713274 | 3 | 0 | 3 |
| IRX3 | DECR1 | 0.713189 | 3 | 0 | 3 |
For details and further investigation, click here
