| Full name: E2F transcription factor 2 | Alias Symbol: E2F-2 | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 1870 | HGNC ID: HGNC:3114 | Ensembl Gene: ENSG00000007968 | OMIM ID: 600426 |
| Drug and gene relationship at DGIdb | |||
E2F2 involved pathways:
Expression of E2F2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | E2F2 | 1870 | 228361_at | 0.2264 | 0.6068 | |
| GSE20347 | E2F2 | 1870 | 207042_at | -0.0606 | 0.4035 | |
| GSE23400 | E2F2 | 1870 | 207042_at | -0.1315 | 0.0000 | |
| GSE26886 | E2F2 | 1870 | 228361_at | -0.9855 | 0.0000 | |
| GSE29001 | E2F2 | 1870 | 207042_at | -0.1085 | 0.2793 | |
| GSE38129 | E2F2 | 1870 | 207042_at | -0.0610 | 0.3361 | |
| GSE45670 | E2F2 | 1870 | 228361_at | 0.0697 | 0.7156 | |
| GSE53622 | E2F2 | 1870 | 91532 | 0.2030 | 0.4070 | |
| GSE53624 | E2F2 | 1870 | 91532 | 0.1024 | 0.2881 | |
| GSE63941 | E2F2 | 1870 | 228361_at | 1.5477 | 0.0002 | |
| GSE77861 | E2F2 | 1870 | 228361_at | -0.2002 | 0.0793 | |
| GSE97050 | E2F2 | 1870 | A_23_P408955 | 0.7849 | 0.1667 | |
| SRP007169 | E2F2 | 1870 | RNAseq | 0.1024 | 0.8872 | |
| SRP064894 | E2F2 | 1870 | RNAseq | -0.1326 | 0.6672 | |
| SRP133303 | E2F2 | 1870 | RNAseq | -0.2051 | 0.3715 | |
| SRP159526 | E2F2 | 1870 | RNAseq | -0.0752 | 0.7382 | |
| SRP193095 | E2F2 | 1870 | RNAseq | -0.2523 | 0.0877 | |
| SRP219564 | E2F2 | 1870 | RNAseq | -0.4851 | 0.5402 | |
| TCGA | E2F2 | 1870 | RNAseq | 0.9336 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by E2F2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of E2F2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | E2F2 | 1870 | 0 | 5 | 25 | |
| GSE20123 | E2F2 | 1870 | 0 | 4 | 26 | |
| GSE43470 | E2F2 | 1870 | 2 | 6 | 35 | |
| GSE46452 | E2F2 | 1870 | 5 | 1 | 53 | |
| GSE47630 | E2F2 | 1870 | 8 | 3 | 29 | |
| GSE54993 | E2F2 | 1870 | 2 | 1 | 67 | |
| GSE54994 | E2F2 | 1870 | 11 | 4 | 38 | |
| GSE60625 | E2F2 | 1870 | 0 | 0 | 11 | |
| GSE74703 | E2F2 | 1870 | 1 | 4 | 31 | |
| GSE74704 | E2F2 | 1870 | 0 | 0 | 20 | |
| TCGA | E2F2 | 1870 | 9 | 23 | 64 |
Total number of gains: 38; Total number of losses: 51; Total Number of normals: 399.
Somatic mutations of E2F2:
Generating mutation plots.
Highly correlated genes for E2F2:
Showing top 20/601 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| E2F2 | BROX | 0.825768 | 3 | 0 | 3 |
| E2F2 | PPP4C | 0.790141 | 4 | 0 | 4 |
| E2F2 | ARNTL2 | 0.773601 | 3 | 0 | 3 |
| E2F2 | JUP | 0.762889 | 4 | 0 | 4 |
| E2F2 | SLC22A23 | 0.751029 | 3 | 0 | 3 |
| E2F2 | RCC1 | 0.745542 | 5 | 0 | 4 |
| E2F2 | CERS3 | 0.740034 | 4 | 0 | 4 |
| E2F2 | AIF1L | 0.736098 | 3 | 0 | 3 |
| E2F2 | DSC3 | 0.732795 | 5 | 0 | 5 |
| E2F2 | KDF1 | 0.732696 | 4 | 0 | 4 |
| E2F2 | CXADR | 0.730001 | 3 | 0 | 3 |
| E2F2 | STK38 | 0.725351 | 3 | 0 | 3 |
| E2F2 | DMKN | 0.725345 | 4 | 0 | 4 |
| E2F2 | SLC25A39 | 0.724234 | 5 | 0 | 4 |
| E2F2 | KIAA1522 | 0.721794 | 5 | 0 | 4 |
| E2F2 | SRP68 | 0.710709 | 4 | 0 | 4 |
| E2F2 | SPTLC3 | 0.708667 | 3 | 0 | 3 |
| E2F2 | AP1S3 | 0.707824 | 4 | 0 | 4 |
| E2F2 | NUDT21 | 0.700027 | 3 | 0 | 3 |
| E2F2 | PUS7L | 0.697528 | 3 | 0 | 3 |
For details and further investigation, click here
