PRKACG

 

Full name: protein kinase cAMP-activated catalytic subunit gamma Alias Symbol: PKACg
Type: protein-coding gene Cytoband: 9q21.11
Entrez ID: 5568 HGNC ID: HGNC:9382 Ensembl Gene: ENSG00000165059 OMIM ID: 176893
Drug and gene relationship at DGIdb
Screen Evidence:

 

PRKACG involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04020Calcium signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04114Oocyte meiosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04740Olfactory transduction
hsa04742Taste transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04910Insulin signaling pathway
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04976Bile secretion
hsa05012Parkinson's disease
hsa05020Prion diseases
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05032Morphine addiction
hsa05110Vibrio cholerae infection
hsa05166HTLV-I infection
hsa05205Proteoglycans in cancer

 

Expression of PRKACG:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKACG 5568 207228_at -0.0621 0.8149
GSE20347 PRKACG 5568 207228_at 0.0194 0.8222
GSE23400 PRKACG 5568 207228_at -0.0613 0.0424
GSE26886 PRKACG 5568 207228_at -0.1379 0.1187
GSE29001 PRKACG 5568 207228_at -0.1221 0.3336
GSE38129 PRKACG 5568 207228_at -0.1169 0.1535
GSE45670 PRKACG 5568 207228_at -0.0626 0.4331
GSE53622 PRKACG 5568 38632 -0.1736 0.0481
GSE53624 PRKACG 5568 38632 -0.0773 0.4106
GSE63941 PRKACG 5568 207228_at 0.0342 0.8257
GSE77861 PRKACG 5568 207228_at -0.2548 0.0203
GSE97050 PRKACG 5568 A_23_P71926 -0.0304 0.9133

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PRKACG expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKACG:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKACG 5568 6 10 14
GSE20123 PRKACG 5568 6 10 14
GSE43470 PRKACG 5568 6 5 32
GSE46452 PRKACG 5568 7 14 38
GSE47630 PRKACG 5568 1 19 20
GSE54993 PRKACG 5568 5 1 64
GSE54994 PRKACG 5568 4 13 36
GSE60625 PRKACG 5568 0 0 11
GSE74703 PRKACG 5568 5 4 27
GSE74704 PRKACG 5568 3 7 10
TCGA PRKACG 5568 18 28 50

Total number of gains: 61; Total number of losses: 111; Total Number of normals: 316.  

 

Somatic mutations of PRKACG:

 

Generating mutation plots.

 

Highly correlated genes for PRKACG:

 

Showing top 20/716 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKACGGYPC0.745506303
PRKACGCNTF0.736745303
PRKACGGRPR0.718424404
PRKACGRUNX1T10.714544303
PRKACGGABRA50.711846303
PRKACGOR12D20.707489404
PRKACGFSTL40.707431404
PRKACGCGA0.706871404
PRKACGGADL10.704147303
PRKACGOR10J10.697492303
PRKACGKAT70.696703303
PRKACGASH1L0.695475303
PRKACGGDF20.693005404
PRKACGMAP1A0.689224403
PRKACGNTRK30.686091404
PRKACGCCDC870.685181404
PRKACGNTNG10.684969303
PRKACGEVC20.684534303
PRKACGSERPINA50.68319505
PRKACGIQSEC20.682782505

For details and further investigation, click here