| Full name: EvC ciliary complex subunit 2 | Alias Symbol: LBN | ||
| Type: protein-coding gene | Cytoband: 4p16.2 | ||
| Entrez ID: 132884 | HGNC ID: HGNC:19747 | Ensembl Gene: ENSG00000173040 | OMIM ID: 607261 |
| Drug and gene relationship at DGIdb | |||
EVC2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04340 | Hedgehog signaling pathway |
Expression of EVC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EVC2 | 132884 | 229974_at | -0.5764 | 0.1248 | |
| GSE26886 | EVC2 | 132884 | 1555256_at | 0.0655 | 0.6582 | |
| GSE45670 | EVC2 | 132884 | 229974_at | -0.3881 | 0.1800 | |
| GSE53622 | EVC2 | 132884 | 63039 | 0.0029 | 0.9859 | |
| GSE53624 | EVC2 | 132884 | 63039 | -0.0908 | 0.4297 | |
| GSE63941 | EVC2 | 132884 | 1555256_at | -0.0643 | 0.7937 | |
| GSE77861 | EVC2 | 132884 | 1555256_at | -0.1676 | 0.1118 | |
| GSE97050 | EVC2 | 132884 | A_33_P3319880 | -0.0444 | 0.8375 | |
| SRP064894 | EVC2 | 132884 | RNAseq | -0.2080 | 0.4003 | |
| SRP133303 | EVC2 | 132884 | RNAseq | 0.0222 | 0.9123 | |
| SRP159526 | EVC2 | 132884 | RNAseq | 0.1874 | 0.6188 | |
| SRP193095 | EVC2 | 132884 | RNAseq | -0.0221 | 0.9329 | |
| SRP219564 | EVC2 | 132884 | RNAseq | -0.7855 | 0.1830 | |
| TCGA | EVC2 | 132884 | RNAseq | 0.0449 | 0.8237 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EVC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EVC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EVC2 | 132884 | 0 | 18 | 12 | |
| GSE20123 | EVC2 | 132884 | 0 | 18 | 12 | |
| GSE43470 | EVC2 | 132884 | 0 | 16 | 27 | |
| GSE46452 | EVC2 | 132884 | 1 | 36 | 22 | |
| GSE47630 | EVC2 | 132884 | 1 | 19 | 20 | |
| GSE54993 | EVC2 | 132884 | 10 | 0 | 60 | |
| GSE54994 | EVC2 | 132884 | 3 | 12 | 38 | |
| GSE60625 | EVC2 | 132884 | 0 | 0 | 11 | |
| GSE74703 | EVC2 | 132884 | 0 | 13 | 23 | |
| GSE74704 | EVC2 | 132884 | 0 | 10 | 10 | |
| TCGA | EVC2 | 132884 | 7 | 49 | 40 |
Total number of gains: 22; Total number of losses: 191; Total Number of normals: 275.
Somatic mutations of EVC2:
Generating mutation plots.
Highly correlated genes for EVC2:
Showing top 20/167 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EVC2 | CD59 | 0.81704 | 3 | 0 | 3 |
| EVC2 | KDM5D | 0.80943 | 3 | 0 | 3 |
| EVC2 | SLC30A4 | 0.791042 | 3 | 0 | 3 |
| EVC2 | APIP | 0.783289 | 3 | 0 | 3 |
| EVC2 | LMO2 | 0.776554 | 3 | 0 | 3 |
| EVC2 | OPTN | 0.771793 | 3 | 0 | 3 |
| EVC2 | CHMP2B | 0.770176 | 3 | 0 | 3 |
| EVC2 | CALY | 0.761775 | 3 | 0 | 3 |
| EVC2 | GNG12 | 0.761399 | 3 | 0 | 3 |
| EVC2 | NLGN4Y | 0.759549 | 3 | 0 | 3 |
| EVC2 | PHYHD1 | 0.75869 | 3 | 0 | 3 |
| EVC2 | SCARF1 | 0.751713 | 3 | 0 | 3 |
| EVC2 | FBXO3 | 0.750592 | 3 | 0 | 3 |
| EVC2 | RRAD | 0.749086 | 3 | 0 | 3 |
| EVC2 | EIF1AY | 0.747536 | 3 | 0 | 3 |
| EVC2 | TRIM3 | 0.746084 | 3 | 0 | 3 |
| EVC2 | EIF4E3 | 0.739493 | 3 | 0 | 3 |
| EVC2 | USP9Y | 0.737166 | 3 | 0 | 3 |
| EVC2 | PAIP2 | 0.73574 | 3 | 0 | 3 |
| EVC2 | ARL6IP5 | 0.732167 | 3 | 0 | 3 |
For details and further investigation, click here
