| Full name: ASH1 like histone lysine methyltransferase | Alias Symbol: huASH1|ASH1|ASH1L1|KMT2H | ||
| Type: protein-coding gene | Cytoband: 1q22 | ||
| Entrez ID: 55870 | HGNC ID: HGNC:19088 | Ensembl Gene: ENSG00000116539 | OMIM ID: 607999 |
| Drug and gene relationship at DGIdb | |||
Expression of ASH1L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASH1L | 55870 | 222667_s_at | 0.0138 | 0.9892 | |
| GSE20347 | ASH1L | 55870 | 218554_s_at | -0.0333 | 0.6668 | |
| GSE23400 | ASH1L | 55870 | 218554_s_at | -0.0755 | 0.0608 | |
| GSE26886 | ASH1L | 55870 | 226447_at | 0.2372 | 0.3656 | |
| GSE29001 | ASH1L | 55870 | 218554_s_at | -0.1989 | 0.3188 | |
| GSE38129 | ASH1L | 55870 | 218554_s_at | -0.0567 | 0.4531 | |
| GSE45670 | ASH1L | 55870 | 222667_s_at | -0.4036 | 0.0027 | |
| GSE53622 | ASH1L | 55870 | 50469 | -0.3652 | 0.0002 | |
| GSE53624 | ASH1L | 55870 | 50469 | -0.0289 | 0.7179 | |
| GSE63941 | ASH1L | 55870 | 226447_at | -0.3759 | 0.2520 | |
| GSE77861 | ASH1L | 55870 | 226447_at | 0.0484 | 0.8630 | |
| GSE97050 | ASH1L | 55870 | A_33_P3402725 | -0.3565 | 0.2433 | |
| SRP007169 | ASH1L | 55870 | RNAseq | 0.1872 | 0.5346 | |
| SRP008496 | ASH1L | 55870 | RNAseq | 0.5328 | 0.0079 | |
| SRP064894 | ASH1L | 55870 | RNAseq | -0.4781 | 0.0831 | |
| SRP133303 | ASH1L | 55870 | RNAseq | -0.0513 | 0.6608 | |
| SRP159526 | ASH1L | 55870 | RNAseq | 0.0404 | 0.8328 | |
| SRP193095 | ASH1L | 55870 | RNAseq | 0.0422 | 0.5791 | |
| SRP219564 | ASH1L | 55870 | RNAseq | -0.1710 | 0.6092 | |
| TCGA | ASH1L | 55870 | RNAseq | -0.1024 | 0.0208 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ASH1L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASH1L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASH1L | 55870 | 14 | 0 | 16 | |
| GSE20123 | ASH1L | 55870 | 13 | 0 | 17 | |
| GSE43470 | ASH1L | 55870 | 7 | 2 | 34 | |
| GSE46452 | ASH1L | 55870 | 2 | 1 | 56 | |
| GSE47630 | ASH1L | 55870 | 14 | 0 | 26 | |
| GSE54993 | ASH1L | 55870 | 0 | 5 | 65 | |
| GSE54994 | ASH1L | 55870 | 16 | 0 | 37 | |
| GSE60625 | ASH1L | 55870 | 0 | 0 | 11 | |
| GSE74703 | ASH1L | 55870 | 7 | 2 | 27 | |
| GSE74704 | ASH1L | 55870 | 6 | 0 | 14 | |
| TCGA | ASH1L | 55870 | 38 | 2 | 56 |
Total number of gains: 117; Total number of losses: 12; Total Number of normals: 359.
Somatic mutations of ASH1L:
Generating mutation plots.
Highly correlated genes for ASH1L:
Showing top 20/344 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASH1L | PLXNB1 | 0.848128 | 3 | 0 | 3 |
| ASH1L | UTP23 | 0.793096 | 3 | 0 | 3 |
| ASH1L | C20orf194 | 0.786297 | 3 | 0 | 3 |
| ASH1L | ATG14 | 0.783394 | 3 | 0 | 3 |
| ASH1L | TAOK3 | 0.772883 | 3 | 0 | 3 |
| ASH1L | SYNE2 | 0.765759 | 3 | 0 | 3 |
| ASH1L | RUFY3 | 0.764665 | 3 | 0 | 3 |
| ASH1L | TADA2B | 0.762876 | 3 | 0 | 3 |
| ASH1L | NUFIP1 | 0.745944 | 3 | 0 | 3 |
| ASH1L | ZNF202 | 0.734591 | 3 | 0 | 3 |
| ASH1L | ZNF814 | 0.732672 | 4 | 0 | 3 |
| ASH1L | EID2 | 0.731779 | 3 | 0 | 3 |
| ASH1L | CRX | 0.731217 | 3 | 0 | 3 |
| ASH1L | ATRNL1 | 0.7312 | 3 | 0 | 3 |
| ASH1L | ARID2 | 0.726668 | 4 | 0 | 4 |
| ASH1L | KCNAB1 | 0.723769 | 3 | 0 | 3 |
| ASH1L | CRBN | 0.720104 | 3 | 0 | 3 |
| ASH1L | ZNF76 | 0.718941 | 3 | 0 | 3 |
| ASH1L | ZNF286A | 0.718405 | 4 | 0 | 4 |
| ASH1L | IL18BP | 0.716312 | 3 | 0 | 3 |
For details and further investigation, click here
