| Full name: gamma-aminobutyric acid type A receptor alpha5 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q12 | ||
| Entrez ID: 2558 | HGNC ID: HGNC:4079 | Ensembl Gene: ENSG00000186297 | OMIM ID: 137142 |
| Drug and gene relationship at DGIdb | |||
GABRA5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa04742 | Taste transduction | |
| hsa05032 | Morphine addiction |
Expression of GABRA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRA5 | 2558 | 217280_x_at | -0.4911 | 0.4623 | |
| GSE20347 | GABRA5 | 2558 | 217280_x_at | -0.0452 | 0.5719 | |
| GSE23400 | GABRA5 | 2558 | 217280_x_at | -0.2302 | 0.0000 | |
| GSE26886 | GABRA5 | 2558 | 217280_x_at | -0.1108 | 0.4152 | |
| GSE29001 | GABRA5 | 2558 | 217280_x_at | -0.0825 | 0.7070 | |
| GSE38129 | GABRA5 | 2558 | 206456_at | -0.6894 | 0.0210 | |
| GSE45670 | GABRA5 | 2558 | 217280_x_at | 0.0899 | 0.2614 | |
| GSE53622 | GABRA5 | 2558 | 101099 | -1.2024 | 0.0029 | |
| GSE53624 | GABRA5 | 2558 | 39137 | -0.9304 | 0.0007 | |
| GSE63941 | GABRA5 | 2558 | 217280_x_at | 0.1851 | 0.3688 | |
| GSE77861 | GABRA5 | 2558 | 215531_s_at | -0.0021 | 0.9905 | |
| GSE97050 | GABRA5 | 2558 | A_23_P436618 | -0.7841 | 0.2240 | |
| SRP159526 | GABRA5 | 2558 | RNAseq | 2.0797 | 0.0170 | |
| TCGA | GABRA5 | 2558 | RNAseq | -0.8913 | 0.2631 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by GABRA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GABRA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRA5 | 2558 | 3 | 7 | 20 | |
| GSE20123 | GABRA5 | 2558 | 3 | 7 | 20 | |
| GSE43470 | GABRA5 | 2558 | 3 | 5 | 35 | |
| GSE46452 | GABRA5 | 2558 | 3 | 7 | 49 | |
| GSE47630 | GABRA5 | 2558 | 8 | 11 | 21 | |
| GSE54993 | GABRA5 | 2558 | 4 | 6 | 60 | |
| GSE54994 | GABRA5 | 2558 | 7 | 6 | 40 | |
| GSE60625 | GABRA5 | 2558 | 4 | 3 | 4 | |
| GSE74703 | GABRA5 | 2558 | 3 | 3 | 30 | |
| GSE74704 | GABRA5 | 2558 | 2 | 5 | 13 | |
| TCGA | GABRA5 | 2558 | 16 | 17 | 63 |
Total number of gains: 56; Total number of losses: 77; Total Number of normals: 355.
Somatic mutations of GABRA5:
Generating mutation plots.
Highly correlated genes for GABRA5:
Showing top 20/832 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRA5 | SYNC | 0.77687 | 3 | 0 | 3 |
| GABRA5 | FOXF2 | 0.763737 | 4 | 0 | 4 |
| GABRA5 | DAB1 | 0.762585 | 3 | 0 | 3 |
| GABRA5 | TMOD1 | 0.752392 | 4 | 0 | 4 |
| GABRA5 | MYOT | 0.746561 | 5 | 0 | 4 |
| GABRA5 | DOCK3 | 0.743601 | 5 | 0 | 5 |
| GABRA5 | CHD5 | 0.743457 | 5 | 0 | 5 |
| GABRA5 | TAGLN3 | 0.732494 | 3 | 0 | 3 |
| GABRA5 | GPR88 | 0.720767 | 4 | 0 | 3 |
| GABRA5 | TAS2R13 | 0.718751 | 3 | 0 | 3 |
| GABRA5 | SCNN1G | 0.717407 | 3 | 0 | 3 |
| GABRA5 | COL4A6 | 0.715796 | 4 | 0 | 3 |
| GABRA5 | NRXN3 | 0.713876 | 6 | 0 | 5 |
| GABRA5 | WFDC3 | 0.713122 | 3 | 0 | 3 |
| GABRA5 | FNDC5 | 0.712293 | 4 | 0 | 3 |
| GABRA5 | PRKACG | 0.711846 | 3 | 0 | 3 |
| GABRA5 | CACNA1C | 0.709612 | 5 | 0 | 4 |
| GABRA5 | ARHGEF25 | 0.70706 | 4 | 0 | 3 |
| GABRA5 | SYT13 | 0.706034 | 3 | 0 | 3 |
| GABRA5 | SOCS3 | 0.705093 | 3 | 0 | 3 |
For details and further investigation, click here
