| Full name: ciliary neurotrophic factor | Alias Symbol: HCNTF | ||
| Type: protein-coding gene | Cytoband: 11q12.1 | ||
| Entrez ID: 1270 | HGNC ID: HGNC:2169 | Ensembl Gene: ENSG00000242689 | OMIM ID: 118945 |
| Drug and gene relationship at DGIdb | |||
CNTF involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of CNTF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE20347 | CNTF | 1270 | 208597_at | 0.0650 | 0.2737 | |
| GSE23400 | CNTF | 1270 | 208597_at | -0.1375 | 0.0112 | |
| GSE29001 | CNTF | 1270 | 208597_at | -0.2068 | 0.3192 | |
| GSE38129 | CNTF | 1270 | 208597_at | -0.0091 | 0.8919 | |
| GSE53622 | CNTF | 1270 | 9913 | -0.3741 | 0.0010 | |
| GSE53624 | CNTF | 1270 | 9913 | 0.4763 | 0.0000 | |
| GSE97050 | CNTF | 1270 | A_33_P3256778 | 0.1792 | 0.5017 | |
| SRP133303 | CNTF | 1270 | RNAseq | -0.2398 | 0.4996 | |
| TCGA | CNTF | 1270 | RNAseq | 0.6472 | 0.0143 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CNTF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNTF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNTF | 1270 | 1 | 4 | 25 | |
| GSE20123 | CNTF | 1270 | 1 | 4 | 25 | |
| GSE43470 | CNTF | 1270 | 1 | 5 | 37 | |
| GSE46452 | CNTF | 1270 | 10 | 4 | 45 | |
| GSE47630 | CNTF | 1270 | 3 | 8 | 29 | |
| GSE54993 | CNTF | 1270 | 3 | 0 | 67 | |
| GSE54994 | CNTF | 1270 | 5 | 6 | 42 | |
| GSE60625 | CNTF | 1270 | 0 | 3 | 8 | |
| GSE74703 | CNTF | 1270 | 1 | 3 | 32 | |
| GSE74704 | CNTF | 1270 | 1 | 4 | 15 | |
| TCGA | CNTF | 1270 | 14 | 10 | 72 |
Total number of gains: 40; Total number of losses: 51; Total Number of normals: 397.
Somatic mutations of CNTF:
Generating mutation plots.
Highly correlated genes for CNTF:
Showing top 20/318 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNTF | GNG3 | 0.797316 | 3 | 0 | 3 |
| CNTF | KCNQ3 | 0.793831 | 3 | 0 | 3 |
| CNTF | OCM2 | 0.791287 | 3 | 0 | 3 |
| CNTF | CISH | 0.789901 | 3 | 0 | 3 |
| CNTF | SEMA6A | 0.785162 | 3 | 0 | 3 |
| CNTF | WDTC1 | 0.780818 | 3 | 0 | 3 |
| CNTF | SARDH | 0.774743 | 3 | 0 | 3 |
| CNTF | KLRG1 | 0.773652 | 3 | 0 | 3 |
| CNTF | RABEP2 | 0.77059 | 3 | 0 | 3 |
| CNTF | ATP6V1G2 | 0.762315 | 3 | 0 | 3 |
| CNTF | HOXC5 | 0.759811 | 3 | 0 | 3 |
| CNTF | CA5B | 0.759107 | 3 | 0 | 3 |
| CNTF | IRF2BP1 | 0.758887 | 3 | 0 | 3 |
| CNTF | RUNX1T1 | 0.746328 | 3 | 0 | 3 |
| CNTF | ADCYAP1 | 0.738788 | 3 | 0 | 3 |
| CNTF | PRKACG | 0.736745 | 3 | 0 | 3 |
| CNTF | PWWP2A | 0.734943 | 4 | 0 | 3 |
| CNTF | UBE2D4 | 0.733299 | 4 | 0 | 4 |
| CNTF | CCDC7 | 0.730287 | 4 | 0 | 3 |
| CNTF | PDPR | 0.724733 | 3 | 0 | 3 |
For details and further investigation, click here
