| Full name: neurotrophic receptor tyrosine kinase 3 | Alias Symbol: TRKC | ||
| Type: protein-coding gene | Cytoband: 15q25.3 | ||
| Entrez ID: 4916 | HGNC ID: HGNC:8033 | Ensembl Gene: ENSG00000140538 | OMIM ID: 191316 |
| Drug and gene relationship at DGIdb | |||
NTRK3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04722 | Neurotrophin signaling pathway |
Expression of NTRK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NTRK3 | 4916 | 217377_x_at | -0.0014 | 0.9965 | |
| GSE20347 | NTRK3 | 4916 | 217377_x_at | 0.1488 | 0.1224 | |
| GSE23400 | NTRK3 | 4916 | 217377_x_at | -0.1478 | 0.0020 | |
| GSE26886 | NTRK3 | 4916 | 217033_x_at | 0.0547 | 0.6753 | |
| GSE29001 | NTRK3 | 4916 | 217033_x_at | -0.2278 | 0.3100 | |
| GSE38129 | NTRK3 | 4916 | 217033_x_at | -0.0970 | 0.4810 | |
| GSE45670 | NTRK3 | 4916 | 228849_at | -0.1123 | 0.2672 | |
| GSE53622 | NTRK3 | 4916 | 38480 | -1.2729 | 0.0000 | |
| GSE53624 | NTRK3 | 4916 | 38480 | -1.9628 | 0.0000 | |
| GSE63941 | NTRK3 | 4916 | 228849_at | 0.2120 | 0.1233 | |
| GSE77861 | NTRK3 | 4916 | 228849_at | -0.0265 | 0.7796 | |
| SRP064894 | NTRK3 | 4916 | RNAseq | -0.9664 | 0.0375 | |
| SRP133303 | NTRK3 | 4916 | RNAseq | -1.6636 | 0.0000 | |
| SRP193095 | NTRK3 | 4916 | RNAseq | -0.0762 | 0.5821 | |
| SRP219564 | NTRK3 | 4916 | RNAseq | -0.8369 | 0.2606 | |
| TCGA | NTRK3 | 4916 | RNAseq | -2.0409 | 0.0016 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by NTRK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NTRK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NTRK3 | 4916 | 7 | 1 | 22 | |
| GSE20123 | NTRK3 | 4916 | 7 | 1 | 22 | |
| GSE43470 | NTRK3 | 4916 | 5 | 4 | 34 | |
| GSE46452 | NTRK3 | 4916 | 3 | 7 | 49 | |
| GSE47630 | NTRK3 | 4916 | 8 | 10 | 22 | |
| GSE54993 | NTRK3 | 4916 | 4 | 6 | 60 | |
| GSE54994 | NTRK3 | 4916 | 7 | 6 | 40 | |
| GSE60625 | NTRK3 | 4916 | 4 | 0 | 7 | |
| GSE74703 | NTRK3 | 4916 | 4 | 3 | 29 | |
| GSE74704 | NTRK3 | 4916 | 4 | 1 | 15 | |
| TCGA | NTRK3 | 4916 | 16 | 14 | 66 |
Total number of gains: 69; Total number of losses: 53; Total Number of normals: 366.
Somatic mutations of NTRK3:
Generating mutation plots.
Highly correlated genes for NTRK3:
Showing top 20/832 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NTRK3 | EDA2R | 0.741247 | 5 | 0 | 5 |
| NTRK3 | PCBP3 | 0.7093 | 3 | 0 | 3 |
| NTRK3 | IFNA17 | 0.706647 | 4 | 0 | 4 |
| NTRK3 | KRTAP5-8 | 0.704851 | 4 | 0 | 4 |
| NTRK3 | LALBA | 0.703998 | 3 | 0 | 3 |
| NTRK3 | NEU3 | 0.702643 | 4 | 0 | 4 |
| NTRK3 | NOS1 | 0.702381 | 5 | 0 | 5 |
| NTRK3 | PKLR | 0.693924 | 4 | 0 | 3 |
| NTRK3 | FCN2 | 0.692056 | 5 | 0 | 5 |
| NTRK3 | ZNF287 | 0.69037 | 3 | 0 | 3 |
| NTRK3 | ATN1 | 0.68913 | 6 | 0 | 6 |
| NTRK3 | PRKACG | 0.686091 | 4 | 0 | 4 |
| NTRK3 | DNMT3L | 0.684503 | 3 | 0 | 3 |
| NTRK3 | FRAS1 | 0.684107 | 4 | 0 | 4 |
| NTRK3 | OR10J1 | 0.682788 | 4 | 0 | 3 |
| NTRK3 | INE1 | 0.680061 | 4 | 0 | 4 |
| NTRK3 | GPRC6A | 0.679958 | 3 | 0 | 3 |
| NTRK3 | FGF21 | 0.676751 | 4 | 0 | 4 |
| NTRK3 | EFR3B | 0.676665 | 4 | 0 | 4 |
| NTRK3 | NMNAT2 | 0.67123 | 4 | 0 | 4 |
For details and further investigation, click here
