| Full name: adenosine deaminase RNA specific | Alias Symbol: ADAR1 | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 103 | HGNC ID: HGNC:225 | Ensembl Gene: ENSG00000160710 | OMIM ID: 146920 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ADAR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAR | 103 | 201786_s_at | 0.8033 | 0.0608 | |
| GSE20347 | ADAR | 103 | 201786_s_at | 0.9143 | 0.0000 | |
| GSE23400 | ADAR | 103 | 201786_s_at | 0.8490 | 0.0000 | |
| GSE26886 | ADAR | 103 | 201786_s_at | 1.1338 | 0.0000 | |
| GSE29001 | ADAR | 103 | 201786_s_at | 0.9858 | 0.0001 | |
| GSE38129 | ADAR | 103 | 201786_s_at | 0.8452 | 0.0000 | |
| GSE45670 | ADAR | 103 | 201786_s_at | 0.9725 | 0.0000 | |
| GSE53622 | ADAR | 103 | 18191 | 0.8520 | 0.0000 | |
| GSE53624 | ADAR | 103 | 18191 | 0.9602 | 0.0000 | |
| GSE63941 | ADAR | 103 | 201786_s_at | 0.7999 | 0.0489 | |
| GSE77861 | ADAR | 103 | 201786_s_at | 1.0076 | 0.0001 | |
| GSE97050 | ADAR | 103 | A_24_P362317 | 0.5205 | 0.1219 | |
| SRP007169 | ADAR | 103 | RNAseq | 1.1740 | 0.0014 | |
| SRP008496 | ADAR | 103 | RNAseq | 1.2179 | 0.0000 | |
| SRP064894 | ADAR | 103 | RNAseq | 0.9342 | 0.0000 | |
| SRP133303 | ADAR | 103 | RNAseq | 0.7912 | 0.0000 | |
| SRP159526 | ADAR | 103 | RNAseq | 0.9088 | 0.0001 | |
| SRP193095 | ADAR | 103 | RNAseq | 0.9265 | 0.0000 | |
| SRP219564 | ADAR | 103 | RNAseq | 1.1197 | 0.0062 | |
| TCGA | ADAR | 103 | RNAseq | 0.1426 | 0.0002 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by ADAR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAR | 103 | 15 | 0 | 15 | |
| GSE20123 | ADAR | 103 | 14 | 0 | 16 | |
| GSE43470 | ADAR | 103 | 6 | 2 | 35 | |
| GSE46452 | ADAR | 103 | 2 | 1 | 56 | |
| GSE47630 | ADAR | 103 | 14 | 0 | 26 | |
| GSE54993 | ADAR | 103 | 0 | 4 | 66 | |
| GSE54994 | ADAR | 103 | 16 | 0 | 37 | |
| GSE60625 | ADAR | 103 | 0 | 0 | 11 | |
| GSE74703 | ADAR | 103 | 6 | 1 | 29 | |
| GSE74704 | ADAR | 103 | 7 | 0 | 13 | |
| TCGA | ADAR | 103 | 38 | 2 | 56 |
Total number of gains: 118; Total number of losses: 10; Total Number of normals: 360.
Somatic mutations of ADAR:
Generating mutation plots.
Highly correlated genes for ADAR:
Showing top 20/2119 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAR | SLC39A3 | 0.845996 | 4 | 0 | 4 |
| ADAR | TMTC4 | 0.810784 | 3 | 0 | 3 |
| ADAR | IRF2BPL | 0.803498 | 3 | 0 | 3 |
| ADAR | CD80 | 0.802346 | 3 | 0 | 3 |
| ADAR | RILPL1 | 0.794232 | 3 | 0 | 3 |
| ADAR | SLC6A6 | 0.790331 | 4 | 0 | 4 |
| ADAR | GNG10 | 0.784759 | 3 | 0 | 3 |
| ADAR | C12orf57 | 0.780432 | 3 | 0 | 3 |
| ADAR | U2SURP | 0.776873 | 9 | 0 | 9 |
| ADAR | CPT1A | 0.776066 | 3 | 0 | 3 |
| ADAR | ZNF408 | 0.770547 | 3 | 0 | 3 |
| ADAR | PPP1R16A | 0.769807 | 3 | 0 | 3 |
| ADAR | MARCKSL1 | 0.768799 | 11 | 0 | 10 |
| ADAR | ZNF579 | 0.76722 | 3 | 0 | 3 |
| ADAR | SSBP4 | 0.766564 | 5 | 0 | 4 |
| ADAR | KRTCAP2 | 0.764587 | 5 | 0 | 5 |
| ADAR | UHMK1 | 0.764412 | 7 | 0 | 7 |
| ADAR | PSMB4 | 0.764284 | 12 | 0 | 11 |
| ADAR | PLXNA1 | 0.762138 | 11 | 0 | 10 |
| ADAR | IFI6 | 0.762074 | 12 | 0 | 11 |
For details and further investigation, click here
