| Full name: cleavage and polyadenylation specific factor 6 | Alias Symbol: CFIM|HPBRII-4|HPBRII-7|CFIM68|CFIM72 | ||
| Type: protein-coding gene | Cytoband: 12q15 | ||
| Entrez ID: 11052 | HGNC ID: HGNC:13871 | Ensembl Gene: ENSG00000111605 | OMIM ID: 604979 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CPSF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CPSF6 | 11052 | 202469_s_at | 0.5416 | 0.1388 | |
| GSE20347 | CPSF6 | 11052 | 202469_s_at | 0.6505 | 0.0000 | |
| GSE23400 | CPSF6 | 11052 | 202469_s_at | 0.8875 | 0.0000 | |
| GSE26886 | CPSF6 | 11052 | 202469_s_at | 1.4361 | 0.0000 | |
| GSE29001 | CPSF6 | 11052 | 202469_s_at | 0.7789 | 0.0003 | |
| GSE38129 | CPSF6 | 11052 | 202469_s_at | 0.7069 | 0.0000 | |
| GSE45670 | CPSF6 | 11052 | 202469_s_at | 0.4529 | 0.0001 | |
| GSE53622 | CPSF6 | 11052 | 7709 | 0.4396 | 0.0000 | |
| GSE53624 | CPSF6 | 11052 | 7709 | 0.4859 | 0.0000 | |
| GSE63941 | CPSF6 | 11052 | 202469_s_at | 0.5363 | 0.0166 | |
| GSE77861 | CPSF6 | 11052 | 202469_s_at | 0.5751 | 0.0047 | |
| GSE97050 | CPSF6 | 11052 | A_24_P121271 | 0.3023 | 0.2226 | |
| SRP007169 | CPSF6 | 11052 | RNAseq | 0.4715 | 0.1435 | |
| SRP008496 | CPSF6 | 11052 | RNAseq | 0.4995 | 0.0039 | |
| SRP064894 | CPSF6 | 11052 | RNAseq | 0.1621 | 0.3582 | |
| SRP133303 | CPSF6 | 11052 | RNAseq | 0.9271 | 0.0019 | |
| SRP159526 | CPSF6 | 11052 | RNAseq | 0.5686 | 0.0128 | |
| SRP193095 | CPSF6 | 11052 | RNAseq | 0.3570 | 0.0000 | |
| SRP219564 | CPSF6 | 11052 | RNAseq | 0.5707 | 0.1834 | |
| TCGA | CPSF6 | 11052 | RNAseq | 0.1103 | 0.0182 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CPSF6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CPSF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CPSF6 | 11052 | 6 | 1 | 23 | |
| GSE20123 | CPSF6 | 11052 | 6 | 0 | 24 | |
| GSE43470 | CPSF6 | 11052 | 5 | 0 | 38 | |
| GSE46452 | CPSF6 | 11052 | 11 | 1 | 47 | |
| GSE47630 | CPSF6 | 11052 | 10 | 1 | 29 | |
| GSE54993 | CPSF6 | 11052 | 0 | 6 | 64 | |
| GSE54994 | CPSF6 | 11052 | 7 | 1 | 45 | |
| GSE60625 | CPSF6 | 11052 | 0 | 0 | 11 | |
| GSE74703 | CPSF6 | 11052 | 5 | 0 | 31 | |
| GSE74704 | CPSF6 | 11052 | 5 | 0 | 15 | |
| TCGA | CPSF6 | 11052 | 23 | 8 | 65 |
Total number of gains: 78; Total number of losses: 18; Total Number of normals: 392.
Somatic mutations of CPSF6:
Generating mutation plots.
Highly correlated genes for CPSF6:
Showing top 20/2071 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CPSF6 | LRRC58 | 0.807748 | 5 | 0 | 5 |
| CPSF6 | C1orf226 | 0.781676 | 3 | 0 | 3 |
| CPSF6 | U2SURP | 0.780142 | 10 | 0 | 9 |
| CPSF6 | RRP15 | 0.779732 | 11 | 0 | 11 |
| CPSF6 | ZNF680 | 0.77973 | 3 | 0 | 3 |
| CPSF6 | RNASEH2B | 0.778632 | 3 | 0 | 3 |
| CPSF6 | SNRPG | 0.776809 | 11 | 0 | 11 |
| CPSF6 | RICTOR | 0.774983 | 3 | 0 | 3 |
| CPSF6 | SNRPE | 0.769499 | 12 | 0 | 12 |
| CPSF6 | ECT2 | 0.768554 | 11 | 0 | 11 |
| CPSF6 | MTERF3 | 0.768226 | 8 | 0 | 8 |
| CPSF6 | RACGAP1 | 0.767077 | 10 | 0 | 10 |
| CPSF6 | PRR12 | 0.766529 | 3 | 0 | 3 |
| CPSF6 | C14orf119 | 0.765876 | 3 | 0 | 3 |
| CPSF6 | ZBTB8A | 0.765011 | 3 | 0 | 3 |
| CPSF6 | DNAJC2 | 0.760444 | 12 | 0 | 11 |
| CPSF6 | PSMB4 | 0.760015 | 11 | 0 | 10 |
| CPSF6 | ARHGAP18 | 0.759702 | 3 | 0 | 3 |
| CPSF6 | KIF15 | 0.758951 | 10 | 0 | 10 |
| CPSF6 | C1orf112 | 0.758864 | 10 | 0 | 10 |
For details and further investigation, click here
