| Full name: U2AF homology motif kinase 1 | Alias Symbol: KIS|Kist | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 127933 | HGNC ID: HGNC:19683 | Ensembl Gene: ENSG00000152332 | OMIM ID: 608849 |
| Drug and gene relationship at DGIdb | |||
Expression of UHMK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UHMK1 | 127933 | 224691_at | 1.0319 | 0.0152 | |
| GSE26886 | UHMK1 | 127933 | 224691_at | 0.4306 | 0.0400 | |
| GSE45670 | UHMK1 | 127933 | 224691_at | 0.7107 | 0.0000 | |
| GSE53622 | UHMK1 | 127933 | 145507 | 0.6454 | 0.0000 | |
| GSE53624 | UHMK1 | 127933 | 128241 | 0.6313 | 0.0000 | |
| GSE63941 | UHMK1 | 127933 | 224691_at | -0.4396 | 0.2695 | |
| GSE77861 | UHMK1 | 127933 | 224691_at | 0.8550 | 0.0089 | |
| GSE97050 | UHMK1 | 127933 | A_23_P342067 | 0.5760 | 0.1536 | |
| SRP007169 | UHMK1 | 127933 | RNAseq | 0.9465 | 0.0049 | |
| SRP008496 | UHMK1 | 127933 | RNAseq | 1.1420 | 0.0000 | |
| SRP064894 | UHMK1 | 127933 | RNAseq | 0.4540 | 0.0283 | |
| SRP133303 | UHMK1 | 127933 | RNAseq | 0.9518 | 0.0000 | |
| SRP159526 | UHMK1 | 127933 | RNAseq | 0.6387 | 0.0183 | |
| SRP193095 | UHMK1 | 127933 | RNAseq | 0.4345 | 0.0000 | |
| SRP219564 | UHMK1 | 127933 | RNAseq | 0.6235 | 0.1577 | |
| TCGA | UHMK1 | 127933 | RNAseq | 0.0660 | 0.3903 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by UHMK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UHMK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UHMK1 | 127933 | 10 | 0 | 20 | |
| GSE20123 | UHMK1 | 127933 | 10 | 0 | 20 | |
| GSE43470 | UHMK1 | 127933 | 7 | 2 | 34 | |
| GSE46452 | UHMK1 | 127933 | 2 | 1 | 56 | |
| GSE47630 | UHMK1 | 127933 | 14 | 0 | 26 | |
| GSE54993 | UHMK1 | 127933 | 0 | 5 | 65 | |
| GSE54994 | UHMK1 | 127933 | 16 | 0 | 37 | |
| GSE60625 | UHMK1 | 127933 | 0 | 0 | 11 | |
| GSE74703 | UHMK1 | 127933 | 7 | 2 | 27 | |
| GSE74704 | UHMK1 | 127933 | 4 | 0 | 16 | |
| TCGA | UHMK1 | 127933 | 43 | 4 | 49 |
Total number of gains: 113; Total number of losses: 14; Total Number of normals: 361.
Somatic mutations of UHMK1:
Generating mutation plots.
Highly correlated genes for UHMK1:
Showing top 20/1361 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UHMK1 | RNF4 | 0.816654 | 3 | 0 | 3 |
| UHMK1 | RAD1 | 0.813927 | 4 | 0 | 4 |
| UHMK1 | ORC2 | 0.798773 | 3 | 0 | 3 |
| UHMK1 | FZD6 | 0.793285 | 5 | 0 | 5 |
| UHMK1 | ANKRD54 | 0.790002 | 3 | 0 | 3 |
| UHMK1 | ZNF284 | 0.788074 | 3 | 0 | 3 |
| UHMK1 | KIAA0100 | 0.781442 | 3 | 0 | 3 |
| UHMK1 | TOMM20 | 0.770204 | 4 | 0 | 4 |
| UHMK1 | PLAGL2 | 0.766956 | 3 | 0 | 3 |
| UHMK1 | ADAR | 0.764412 | 7 | 0 | 7 |
| UHMK1 | PSMB4 | 0.763159 | 7 | 0 | 7 |
| UHMK1 | SLBP | 0.76181 | 5 | 0 | 5 |
| UHMK1 | TGFBRAP1 | 0.755559 | 3 | 0 | 3 |
| UHMK1 | FAM102B | 0.751521 | 3 | 0 | 3 |
| UHMK1 | NCAPG | 0.74966 | 4 | 0 | 4 |
| UHMK1 | GABPB1 | 0.748146 | 4 | 0 | 4 |
| UHMK1 | NPLOC4 | 0.745359 | 3 | 0 | 3 |
| UHMK1 | DLG5 | 0.743622 | 3 | 0 | 3 |
| UHMK1 | NUF2 | 0.743541 | 6 | 0 | 6 |
| UHMK1 | ARPC1B | 0.741065 | 6 | 0 | 6 |
For details and further investigation, click here
