| Full name: prospero homeobox 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q32.3 | ||
| Entrez ID: 5629 | HGNC ID: HGNC:9459 | Ensembl Gene: ENSG00000117707 | OMIM ID: 601546 |
| Drug and gene relationship at DGIdb | |||
Expression of PROX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PROX1 | 5629 | 242119_at | 0.0145 | 0.9611 | |
| GSE20347 | PROX1 | 5629 | 207401_at | 0.0810 | 0.2447 | |
| GSE23400 | PROX1 | 5629 | 207401_at | -0.0104 | 0.6782 | |
| GSE26886 | PROX1 | 5629 | 242119_at | 0.2980 | 0.0125 | |
| GSE29001 | PROX1 | 5629 | 207401_at | -0.0711 | 0.6077 | |
| GSE38129 | PROX1 | 5629 | 207401_at | 0.1017 | 0.5323 | |
| GSE45670 | PROX1 | 5629 | 242119_at | 0.2007 | 0.0068 | |
| GSE53622 | PROX1 | 5629 | 37566 | -0.2354 | 0.1444 | |
| GSE53624 | PROX1 | 5629 | 37566 | 0.0656 | 0.7386 | |
| GSE63941 | PROX1 | 5629 | 242119_at | 0.0183 | 0.9044 | |
| GSE77861 | PROX1 | 5629 | 242119_at | 0.1640 | 0.1994 | |
| GSE97050 | PROX1 | 5629 | A_24_P88266 | 0.3093 | 0.2710 | |
| SRP007169 | PROX1 | 5629 | RNAseq | 1.9695 | 0.0121 | |
| SRP133303 | PROX1 | 5629 | RNAseq | -0.4910 | 0.2677 | |
| SRP159526 | PROX1 | 5629 | RNAseq | 0.3877 | 0.4452 | |
| SRP193095 | PROX1 | 5629 | RNAseq | 0.6115 | 0.1452 | |
| SRP219564 | PROX1 | 5629 | RNAseq | -0.3220 | 0.6600 | |
| TCGA | PROX1 | 5629 | RNAseq | -0.5666 | 0.1183 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PROX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PROX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PROX1 | 5629 | 9 | 0 | 21 | |
| GSE20123 | PROX1 | 5629 | 9 | 0 | 21 | |
| GSE43470 | PROX1 | 5629 | 7 | 1 | 35 | |
| GSE46452 | PROX1 | 5629 | 3 | 1 | 55 | |
| GSE47630 | PROX1 | 5629 | 15 | 0 | 25 | |
| GSE54993 | PROX1 | 5629 | 0 | 6 | 64 | |
| GSE54994 | PROX1 | 5629 | 14 | 0 | 39 | |
| GSE60625 | PROX1 | 5629 | 0 | 0 | 11 | |
| GSE74703 | PROX1 | 5629 | 7 | 1 | 28 | |
| GSE74704 | PROX1 | 5629 | 3 | 0 | 17 | |
| TCGA | PROX1 | 5629 | 44 | 3 | 49 |
Total number of gains: 111; Total number of losses: 12; Total Number of normals: 365.
Somatic mutations of PROX1:
Generating mutation plots.
Highly correlated genes for PROX1:
Showing top 20/472 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PROX1 | RARA | 0.852154 | 3 | 0 | 3 |
| PROX1 | DNAH11 | 0.767561 | 3 | 0 | 3 |
| PROX1 | SAMD4B | 0.765953 | 4 | 0 | 4 |
| PROX1 | FTO | 0.764853 | 3 | 0 | 3 |
| PROX1 | LIMK1 | 0.739247 | 3 | 0 | 3 |
| PROX1 | MGAT4C | 0.732215 | 3 | 0 | 3 |
| PROX1 | KLF7 | 0.731388 | 3 | 0 | 3 |
| PROX1 | SIVA1 | 0.728702 | 3 | 0 | 3 |
| PROX1 | PPP1R1C | 0.728332 | 3 | 0 | 3 |
| PROX1 | C9orf16 | 0.723573 | 3 | 0 | 3 |
| PROX1 | SST | 0.72352 | 3 | 0 | 3 |
| PROX1 | ACIN1 | 0.722991 | 3 | 0 | 3 |
| PROX1 | LRP5 | 0.720561 | 3 | 0 | 3 |
| PROX1 | CHML | 0.718232 | 3 | 0 | 3 |
| PROX1 | ENG | 0.716283 | 3 | 0 | 3 |
| PROX1 | TMEM150A | 0.714172 | 3 | 0 | 3 |
| PROX1 | WNT7B | 0.7139 | 3 | 0 | 3 |
| PROX1 | AAAS | 0.708993 | 3 | 0 | 3 |
| PROX1 | SCARB1 | 0.707767 | 3 | 0 | 3 |
| PROX1 | CACNB1 | 0.707522 | 4 | 0 | 3 |
For details and further investigation, click here
