| Full name: HIC ZBTB transcriptional repressor 1 | Alias Symbol: ZBTB29|ZNF901 | ||
| Type: protein-coding gene | Cytoband: 17p13.3 | ||
| Entrez ID: 3090 | HGNC ID: HGNC:4909 | Ensembl Gene: ENSG00000177374 | OMIM ID: 603825 |
| Drug and gene relationship at DGIdb | |||
Expression of HIC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HIC1 | 3090 | 230218_at | 0.4135 | 0.3473 | |
| GSE20347 | HIC1 | 3090 | 208461_at | 0.0287 | 0.6886 | |
| GSE23400 | HIC1 | 3090 | 208461_at | -0.0623 | 0.0034 | |
| GSE26886 | HIC1 | 3090 | 230218_at | 0.6374 | 0.0008 | |
| GSE29001 | HIC1 | 3090 | 208461_at | -0.0925 | 0.3753 | |
| GSE38129 | HIC1 | 3090 | 208461_at | -0.0147 | 0.8449 | |
| GSE45670 | HIC1 | 3090 | 230218_at | -0.3280 | 0.0283 | |
| GSE53622 | HIC1 | 3090 | 32362 | 0.0951 | 0.5473 | |
| GSE53624 | HIC1 | 3090 | 32362 | 0.3259 | 0.0062 | |
| GSE63941 | HIC1 | 3090 | 230218_at | -0.8259 | 0.0024 | |
| GSE77861 | HIC1 | 3090 | 230218_at | 0.1077 | 0.5496 | |
| GSE97050 | HIC1 | 3090 | A_23_P129856 | -0.0084 | 0.9806 | |
| SRP007169 | HIC1 | 3090 | RNAseq | 2.2018 | 0.0265 | |
| SRP064894 | HIC1 | 3090 | RNAseq | 0.9786 | 0.0010 | |
| SRP133303 | HIC1 | 3090 | RNAseq | -0.1316 | 0.5867 | |
| SRP159526 | HIC1 | 3090 | RNAseq | 0.4858 | 0.1678 | |
| SRP193095 | HIC1 | 3090 | RNAseq | 0.6315 | 0.0119 | |
| SRP219564 | HIC1 | 3090 | RNAseq | 0.5143 | 0.5233 | |
| TCGA | HIC1 | 3090 | RNAseq | -0.1896 | 0.0744 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HIC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HIC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HIC1 | 3090 | 4 | 2 | 24 | |
| GSE20123 | HIC1 | 3090 | 4 | 3 | 23 | |
| GSE43470 | HIC1 | 3090 | 1 | 6 | 36 | |
| GSE46452 | HIC1 | 3090 | 34 | 1 | 24 | |
| GSE47630 | HIC1 | 3090 | 7 | 1 | 32 | |
| GSE54993 | HIC1 | 3090 | 4 | 3 | 63 | |
| GSE54994 | HIC1 | 3090 | 8 | 8 | 37 | |
| GSE60625 | HIC1 | 3090 | 4 | 0 | 7 | |
| GSE74703 | HIC1 | 3090 | 1 | 3 | 32 | |
| GSE74704 | HIC1 | 3090 | 2 | 1 | 17 | |
| TCGA | HIC1 | 3090 | 18 | 21 | 57 |
Total number of gains: 87; Total number of losses: 49; Total Number of normals: 352.
Somatic mutations of HIC1:
Generating mutation plots.
Highly correlated genes for HIC1:
Showing top 20/800 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HIC1 | C1orf122 | 0.761941 | 3 | 0 | 3 |
| HIC1 | PI16 | 0.754633 | 3 | 0 | 3 |
| HIC1 | RARA | 0.754564 | 3 | 0 | 3 |
| HIC1 | UAP1 | 0.750857 | 3 | 0 | 3 |
| HIC1 | PMP22 | 0.740878 | 7 | 0 | 7 |
| HIC1 | TNFSF12 | 0.738671 | 3 | 0 | 3 |
| HIC1 | C11orf96 | 0.737176 | 4 | 0 | 3 |
| HIC1 | IRF1 | 0.735881 | 3 | 0 | 3 |
| HIC1 | COL11A1 | 0.734446 | 3 | 0 | 3 |
| HIC1 | CLIC4 | 0.733857 | 4 | 0 | 4 |
| HIC1 | POSTN | 0.732999 | 4 | 0 | 3 |
| HIC1 | SERPINE1 | 0.732398 | 4 | 0 | 4 |
| HIC1 | ICAM5 | 0.731102 | 3 | 0 | 3 |
| HIC1 | ANKRD9 | 0.731074 | 3 | 0 | 3 |
| HIC1 | PLEKHO2 | 0.727079 | 6 | 0 | 5 |
| HIC1 | PON2 | 0.7267 | 3 | 0 | 3 |
| HIC1 | ENG | 0.726625 | 7 | 0 | 7 |
| HIC1 | A1BG | 0.724758 | 4 | 0 | 4 |
| HIC1 | TOR1B | 0.72425 | 3 | 0 | 3 |
| HIC1 | ZNF343 | 0.722599 | 3 | 0 | 3 |
For details and further investigation, click here
