| Full name: cholinergic receptor nicotinic beta 2 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 1141 | HGNC ID: HGNC:1962 | Ensembl Gene: ENSG00000160716 | OMIM ID: 118507 |
| Drug and gene relationship at DGIdb | |||
CHRNB2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04725 | Cholinergic synapse |
Expression of CHRNB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRNB2 | 1141 | 206635_at | 0.0781 | 0.7221 | |
| GSE20347 | CHRNB2 | 1141 | 206635_at | 0.0040 | 0.9679 | |
| GSE23400 | CHRNB2 | 1141 | 206635_at | -0.0589 | 0.0981 | |
| GSE26886 | CHRNB2 | 1141 | 206635_at | 0.0525 | 0.6875 | |
| GSE29001 | CHRNB2 | 1141 | 206635_at | -0.4151 | 0.0292 | |
| GSE38129 | CHRNB2 | 1141 | 206635_at | -0.0749 | 0.4193 | |
| GSE45670 | CHRNB2 | 1141 | 206635_at | 0.1701 | 0.0820 | |
| GSE53622 | CHRNB2 | 1141 | 33239 | -0.6817 | 0.0007 | |
| GSE53624 | CHRNB2 | 1141 | 33239 | -1.6511 | 0.0000 | |
| GSE63941 | CHRNB2 | 1141 | 206635_at | 0.2148 | 0.2226 | |
| GSE77861 | CHRNB2 | 1141 | 206635_at | 0.0034 | 0.9794 | |
| SRP133303 | CHRNB2 | 1141 | RNAseq | -0.3427 | 0.2712 | |
| SRP193095 | CHRNB2 | 1141 | RNAseq | 0.6579 | 0.0002 | |
| TCGA | CHRNB2 | 1141 | RNAseq | -0.4603 | 0.2205 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CHRNB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRNB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRNB2 | 1141 | 15 | 0 | 15 | |
| GSE20123 | CHRNB2 | 1141 | 14 | 0 | 16 | |
| GSE43470 | CHRNB2 | 1141 | 6 | 2 | 35 | |
| GSE46452 | CHRNB2 | 1141 | 2 | 1 | 56 | |
| GSE47630 | CHRNB2 | 1141 | 14 | 0 | 26 | |
| GSE54993 | CHRNB2 | 1141 | 0 | 4 | 66 | |
| GSE54994 | CHRNB2 | 1141 | 16 | 0 | 37 | |
| GSE60625 | CHRNB2 | 1141 | 0 | 0 | 11 | |
| GSE74703 | CHRNB2 | 1141 | 6 | 1 | 29 | |
| GSE74704 | CHRNB2 | 1141 | 7 | 0 | 13 | |
| TCGA | CHRNB2 | 1141 | 38 | 2 | 56 |
Total number of gains: 118; Total number of losses: 10; Total Number of normals: 360.
Somatic mutations of CHRNB2:
Generating mutation plots.
Highly correlated genes for CHRNB2:
Showing top 20/645 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRNB2 | GRIN2A | 0.737762 | 3 | 0 | 3 |
| CHRNB2 | CACNA1H | 0.717547 | 3 | 0 | 3 |
| CHRNB2 | PTPRU | 0.700394 | 4 | 0 | 4 |
| CHRNB2 | ABCA4 | 0.69713 | 3 | 0 | 3 |
| CHRNB2 | SSTR3 | 0.67994 | 8 | 0 | 7 |
| CHRNB2 | ZNF747 | 0.674336 | 5 | 0 | 5 |
| CHRNB2 | GJB4 | 0.672535 | 5 | 0 | 4 |
| CHRNB2 | SIGLEC15 | 0.672174 | 3 | 0 | 3 |
| CHRNB2 | PHF7 | 0.671381 | 5 | 0 | 4 |
| CHRNB2 | SLC10A1 | 0.671262 | 4 | 0 | 3 |
| CHRNB2 | GDF5 | 0.670609 | 4 | 0 | 3 |
| CHRNB2 | TMEM239 | 0.668899 | 3 | 0 | 3 |
| CHRNB2 | VIPR2 | 0.668407 | 4 | 0 | 4 |
| CHRNB2 | CTRB2 | 0.668228 | 6 | 0 | 6 |
| CHRNB2 | KCNQ1 | 0.663711 | 6 | 0 | 5 |
| CHRNB2 | CASR | 0.663537 | 5 | 0 | 3 |
| CHRNB2 | C16orf71 | 0.66229 | 6 | 0 | 6 |
| CHRNB2 | CCL16 | 0.662262 | 4 | 0 | 3 |
| CHRNB2 | ANGPTL3 | 0.657998 | 3 | 0 | 3 |
| CHRNB2 | FSTL4 | 0.657509 | 5 | 0 | 5 |
For details and further investigation, click here
