| Full name: kallikrein related peptidase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 3817 | HGNC ID: HGNC:6363 | Ensembl Gene: ENSG00000167751 | OMIM ID: 147960 |
| Drug and gene relationship at DGIdb | |||
KLK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04961 | Endocrine and other factor-regulated calcium reabsorption |
Expression of KLK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLK2 | 3817 | 209855_s_at | 0.0783 | 0.7073 | |
| GSE20347 | KLK2 | 3817 | 209855_s_at | 0.0342 | 0.7447 | |
| GSE23400 | KLK2 | 3817 | 209855_s_at | -0.0192 | 0.5965 | |
| GSE26886 | KLK2 | 3817 | 209855_s_at | -0.0990 | 0.4309 | |
| GSE29001 | KLK2 | 3817 | 209855_s_at | 0.0252 | 0.8910 | |
| GSE38129 | KLK2 | 3817 | 209855_s_at | -0.1184 | 0.3949 | |
| GSE45670 | KLK2 | 3817 | 209855_s_at | -0.0391 | 0.6493 | |
| GSE53622 | KLK2 | 3817 | 151210 | -1.2004 | 0.0000 | |
| GSE53624 | KLK2 | 3817 | 151210 | -1.5855 | 0.0000 | |
| GSE63941 | KLK2 | 3817 | 209855_s_at | -0.1413 | 0.3698 | |
| GSE77861 | KLK2 | 3817 | 209855_s_at | -0.0528 | 0.6841 | |
| GSE97050 | KLK2 | 3817 | A_24_P5750 | 0.0929 | 0.6361 | |
| TCGA | KLK2 | 3817 | RNAseq | 3.8608 | 0.0004 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by KLK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLK2 | 3817 | 3 | 4 | 23 | |
| GSE20123 | KLK2 | 3817 | 3 | 3 | 24 | |
| GSE43470 | KLK2 | 3817 | 4 | 11 | 28 | |
| GSE46452 | KLK2 | 3817 | 45 | 1 | 13 | |
| GSE47630 | KLK2 | 3817 | 9 | 6 | 25 | |
| GSE54993 | KLK2 | 3817 | 17 | 4 | 49 | |
| GSE54994 | KLK2 | 3817 | 4 | 14 | 35 | |
| GSE60625 | KLK2 | 3817 | 9 | 0 | 2 | |
| GSE74703 | KLK2 | 3817 | 4 | 7 | 25 | |
| GSE74704 | KLK2 | 3817 | 3 | 1 | 16 | |
| TCGA | KLK2 | 3817 | 14 | 19 | 63 |
Total number of gains: 115; Total number of losses: 70; Total Number of normals: 303.
Somatic mutations of KLK2:
Generating mutation plots.
Highly correlated genes for KLK2:
Showing top 20/904 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLK2 | NOTO | 0.870788 | 3 | 0 | 3 |
| KLK2 | CLEC18C | 0.858738 | 3 | 0 | 3 |
| KLK2 | BARHL2 | 0.823432 | 3 | 0 | 3 |
| KLK2 | RNF222 | 0.818406 | 3 | 0 | 3 |
| KLK2 | SLC39A5 | 0.793941 | 3 | 0 | 3 |
| KLK2 | WDR60 | 0.792787 | 3 | 0 | 3 |
| KLK2 | PGC | 0.789388 | 3 | 0 | 3 |
| KLK2 | TUT1 | 0.781943 | 3 | 0 | 3 |
| KLK2 | GPHB5 | 0.774559 | 4 | 0 | 4 |
| KLK2 | RLN3 | 0.757005 | 3 | 0 | 3 |
| KLK2 | SLC10A6 | 0.754287 | 3 | 0 | 3 |
| KLK2 | STK32C | 0.754102 | 3 | 0 | 3 |
| KLK2 | SLC10A1 | 0.753665 | 5 | 0 | 4 |
| KLK2 | KRTAP5-4 | 0.743777 | 3 | 0 | 3 |
| KLK2 | KRTAP5-5 | 0.743107 | 3 | 0 | 3 |
| KLK2 | FAM163B | 0.739569 | 3 | 0 | 3 |
| KLK2 | FBXO34 | 0.734182 | 3 | 0 | 3 |
| KLK2 | FRMPD2 | 0.733576 | 3 | 0 | 3 |
| KLK2 | NKAIN4 | 0.733487 | 3 | 0 | 3 |
| KLK2 | GPSM3 | 0.732351 | 3 | 0 | 3 |
For details and further investigation, click here
