| Full name: endothelin converting enzyme 2 | Alias Symbol: KIAA0604|MGC2408 | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 9718 | HGNC ID: HGNC:13275 | Ensembl Gene: ENSG00000145194 | OMIM ID: 610145 |
| Drug and gene relationship at DGIdb | |||
Expression of ECE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ECE2 | 9718 | 227103_s_at | 1.0693 | 0.0399 | |
| GSE20347 | ECE2 | 9718 | 206728_at | -0.0443 | 0.7143 | |
| GSE23400 | ECE2 | 9718 | 206728_at | -0.1277 | 0.0002 | |
| GSE26886 | ECE2 | 9718 | 227103_s_at | 0.8236 | 0.0002 | |
| GSE29001 | ECE2 | 9718 | 206728_at | -0.1380 | 0.4980 | |
| GSE38129 | ECE2 | 9718 | 206728_at | -0.2098 | 0.0316 | |
| GSE45670 | ECE2 | 9718 | 227103_s_at | 0.9630 | 0.0012 | |
| GSE53622 | ECE2 | 9718 | 24120 | 1.5149 | 0.0000 | |
| GSE53624 | ECE2 | 9718 | 24120 | 1.7710 | 0.0000 | |
| GSE63941 | ECE2 | 9718 | 227103_s_at | 2.3229 | 0.0036 | |
| GSE77861 | ECE2 | 9718 | 227103_s_at | 0.4414 | 0.0815 | |
| GSE97050 | ECE2 | 9718 | A_23_P92261 | 1.2855 | 0.1867 | |
| TCGA | ECE2 | 9718 | RNAseq | 0.6564 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ECE2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ECE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ECE2 | 9718 | 25 | 0 | 5 | |
| GSE20123 | ECE2 | 9718 | 25 | 0 | 5 | |
| GSE43470 | ECE2 | 9718 | 25 | 0 | 18 | |
| GSE46452 | ECE2 | 9718 | 19 | 1 | 39 | |
| GSE47630 | ECE2 | 9718 | 27 | 2 | 11 | |
| GSE54993 | ECE2 | 9718 | 1 | 19 | 50 | |
| GSE54994 | ECE2 | 9718 | 41 | 0 | 12 | |
| GSE60625 | ECE2 | 9718 | 0 | 6 | 5 | |
| GSE74703 | ECE2 | 9718 | 21 | 0 | 15 | |
| GSE74704 | ECE2 | 9718 | 17 | 0 | 3 | |
| TCGA | ECE2 | 9718 | 77 | 0 | 19 |
Total number of gains: 278; Total number of losses: 28; Total Number of normals: 182.
Somatic mutations of ECE2:
Generating mutation plots.
Highly correlated genes for ECE2:
Showing top 20/1157 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ECE2 | BOP1 | 0.79789 | 3 | 0 | 3 |
| ECE2 | UHRF1 | 0.760912 | 6 | 0 | 6 |
| ECE2 | ALG3 | 0.750747 | 9 | 0 | 8 |
| ECE2 | PLK1 | 0.745714 | 7 | 0 | 7 |
| ECE2 | NOP2 | 0.745307 | 8 | 0 | 7 |
| ECE2 | GML | 0.739544 | 4 | 0 | 4 |
| ECE2 | CDC45 | 0.731194 | 8 | 0 | 7 |
| ECE2 | PAX5 | 0.730054 | 3 | 0 | 3 |
| ECE2 | KIR2DS3 | 0.723805 | 5 | 0 | 5 |
| ECE2 | MRPL47 | 0.72263 | 8 | 0 | 7 |
| ECE2 | CHTF18 | 0.715836 | 5 | 0 | 5 |
| ECE2 | CENPW | 0.715475 | 7 | 0 | 7 |
| ECE2 | CYP2A6 | 0.712286 | 5 | 0 | 5 |
| ECE2 | C19orf48 | 0.709878 | 3 | 0 | 3 |
| ECE2 | P2RX6 | 0.70796 | 4 | 0 | 4 |
| ECE2 | BOLA3 | 0.706671 | 6 | 0 | 6 |
| ECE2 | STIL | 0.703338 | 7 | 0 | 6 |
| ECE2 | DDIAS | 0.702296 | 6 | 0 | 5 |
| ECE2 | CMSS1 | 0.69997 | 7 | 0 | 7 |
| ECE2 | BTN1A1 | 0.698318 | 4 | 0 | 4 |
For details and further investigation, click here
