RBM38

 

Full name: RNA binding motif protein 38 Alias Symbol: HSRNASEB|SEB4D|seb4B|dJ800J21.2
Type: protein-coding gene Cytoband: 20q13.31
Entrez ID: 55544 HGNC ID: HGNC:15818 Ensembl Gene: ENSG00000132819 OMIM ID: 612428
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RBM38:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RBM38 55544 212430_at 1.3148 0.0769
GSE20347 RBM38 55544 212430_at 0.5478 0.0001
GSE23400 RBM38 55544 212430_at 0.1832 0.0674
GSE26886 RBM38 55544 212430_at 0.7058 0.0000
GSE29001 RBM38 55544 212430_at 0.4772 0.0297
GSE38129 RBM38 55544 212430_at 0.2493 0.2621
GSE45670 RBM38 55544 212430_at 0.1590 0.2639
GSE53622 RBM38 55544 7231 0.3702 0.0257
GSE53624 RBM38 55544 7231 0.6987 0.0000
GSE63941 RBM38 55544 212430_at 1.1854 0.0236
GSE77861 RBM38 55544 212430_at 0.6096 0.0257
GSE97050 RBM38 55544 A_23_P17430 -0.3218 0.5619
SRP007169 RBM38 55544 RNAseq 1.8418 0.0004
SRP008496 RBM38 55544 RNAseq 1.9550 0.0002
SRP064894 RBM38 55544 RNAseq 0.7369 0.0093
SRP133303 RBM38 55544 RNAseq 0.3556 0.2190
SRP159526 RBM38 55544 RNAseq 0.7205 0.0781
SRP193095 RBM38 55544 RNAseq 0.9751 0.0000
SRP219564 RBM38 55544 RNAseq -0.2702 0.7117
TCGA RBM38 55544 RNAseq 0.0620 0.3830

Upregulated datasets: 3; Downregulated datasets: 0.  


 

Survival by RBM38 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of RBM38:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RBM38 55544 14 2 14
GSE20123 RBM38 55544 14 2 14
GSE43470 RBM38 55544 13 0 30
GSE46452 RBM38 55544 29 0 30
GSE47630 RBM38 55544 24 1 15
GSE54993 RBM38 55544 0 18 52
GSE54994 RBM38 55544 29 0 24
GSE60625 RBM38 55544 0 0 11
GSE74703 RBM38 55544 11 0 25
GSE74704 RBM38 55544 11 0 9
TCGA RBM38 55544 43 4 49

Total number of gains: 188; Total number of losses: 27; Total Number of normals: 273.  


 

Somatic mutations of RBM38:

 

Generating mutation plots.

 

Highly correlated genes for RBM38:

 

Showing top 20/1255 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RBM38SSBP40.767131404
RBM38ZNF5840.742113303
RBM38MRPL90.740981303
RBM38NDUFB40.733166303
RBM38SLC25A290.730018303
RBM38NFATC40.72812303
RBM38UTP230.724055403
RBM38KRTCAP20.721679404
RBM38COL28A10.716537303
RBM38MCM3AP0.712683303
RBM38RPL35A0.710652303
RBM38ZNF4960.708839504
RBM38SYT70.707529303
RBM38DDX310.704732303
RBM38TEX100.704315303
RBM38RNF40.703661303
RBM38TMEM63B0.703249303
RBM38C1orf350.702095404
RBM38KIAA12570.699978303
RBM38SLC7A6OS0.699072303

For details and further investigation, click here