| Full name: minichromosome maintenance complex component 3 associated protein | Alias Symbol: Map80|KIAA0572|GANP|SAC3 | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 8888 | HGNC ID: HGNC:6946 | Ensembl Gene: ENSG00000160294 | OMIM ID: 603294 |
| Drug and gene relationship at DGIdb | |||
Expression of MCM3AP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MCM3AP | 8888 | 212269_s_at | 0.4398 | 0.1641 | |
| GSE20347 | MCM3AP | 8888 | 215582_x_at | 0.0987 | 0.6146 | |
| GSE23400 | MCM3AP | 8888 | 215582_x_at | -0.0676 | 0.2615 | |
| GSE26886 | MCM3AP | 8888 | 212269_s_at | 0.4486 | 0.1032 | |
| GSE29001 | MCM3AP | 8888 | 212269_s_at | 0.1042 | 0.7599 | |
| GSE38129 | MCM3AP | 8888 | 212269_s_at | 0.0587 | 0.6234 | |
| GSE45670 | MCM3AP | 8888 | 212269_s_at | 0.1872 | 0.1942 | |
| GSE53622 | MCM3AP | 8888 | 135106 | -0.2866 | 0.0000 | |
| GSE53624 | MCM3AP | 8888 | 135106 | -0.1992 | 0.0001 | |
| GSE63941 | MCM3AP | 8888 | 212269_s_at | -1.1908 | 0.0132 | |
| GSE77861 | MCM3AP | 8888 | 212269_s_at | 0.4100 | 0.5479 | |
| GSE97050 | MCM3AP | 8888 | A_23_P120744 | -0.0711 | 0.7373 | |
| SRP007169 | MCM3AP | 8888 | RNAseq | 1.1716 | 0.0211 | |
| SRP008496 | MCM3AP | 8888 | RNAseq | 1.1287 | 0.0008 | |
| SRP064894 | MCM3AP | 8888 | RNAseq | 0.3758 | 0.0166 | |
| SRP133303 | MCM3AP | 8888 | RNAseq | -0.2293 | 0.0438 | |
| SRP159526 | MCM3AP | 8888 | RNAseq | -0.0036 | 0.9799 | |
| SRP193095 | MCM3AP | 8888 | RNAseq | 0.1633 | 0.1136 | |
| SRP219564 | MCM3AP | 8888 | RNAseq | 0.0948 | 0.7169 | |
| TCGA | MCM3AP | 8888 | RNAseq | -0.1252 | 0.0039 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by MCM3AP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MCM3AP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MCM3AP | 8888 | 3 | 9 | 18 | |
| GSE20123 | MCM3AP | 8888 | 3 | 9 | 18 | |
| GSE43470 | MCM3AP | 8888 | 0 | 14 | 29 | |
| GSE46452 | MCM3AP | 8888 | 1 | 21 | 37 | |
| GSE47630 | MCM3AP | 8888 | 6 | 17 | 17 | |
| GSE54993 | MCM3AP | 8888 | 8 | 1 | 61 | |
| GSE54994 | MCM3AP | 8888 | 5 | 8 | 40 | |
| GSE60625 | MCM3AP | 8888 | 0 | 0 | 11 | |
| GSE74703 | MCM3AP | 8888 | 0 | 10 | 26 | |
| GSE74704 | MCM3AP | 8888 | 1 | 5 | 14 | |
| TCGA | MCM3AP | 8888 | 10 | 37 | 49 |
Total number of gains: 37; Total number of losses: 131; Total Number of normals: 320.
Somatic mutations of MCM3AP:
Generating mutation plots.
Highly correlated genes for MCM3AP:
Showing top 20/401 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MCM3AP | ZNF644 | 0.827171 | 3 | 0 | 3 |
| MCM3AP | SCAF4 | 0.808399 | 4 | 0 | 4 |
| MCM3AP | NOC3L | 0.80051 | 3 | 0 | 3 |
| MCM3AP | SMG9 | 0.799582 | 3 | 0 | 3 |
| MCM3AP | DOCK7 | 0.794545 | 3 | 0 | 3 |
| MCM3AP | ETV6 | 0.794387 | 3 | 0 | 3 |
| MCM3AP | FAM161A | 0.78304 | 3 | 0 | 3 |
| MCM3AP | LSG1 | 0.779042 | 3 | 0 | 3 |
| MCM3AP | ZMYND19 | 0.776416 | 3 | 0 | 3 |
| MCM3AP | ZNF830 | 0.772269 | 3 | 0 | 3 |
| MCM3AP | SEC61A1 | 0.768163 | 3 | 0 | 3 |
| MCM3AP | RIOK1 | 0.766319 | 3 | 0 | 3 |
| MCM3AP | DIRAS2 | 0.763632 | 3 | 0 | 3 |
| MCM3AP | CHMP7 | 0.760977 | 4 | 0 | 4 |
| MCM3AP | MRPS26 | 0.757777 | 3 | 0 | 3 |
| MCM3AP | LRRC58 | 0.754374 | 3 | 0 | 3 |
| MCM3AP | DDX10 | 0.749814 | 3 | 0 | 3 |
| MCM3AP | HAS2 | 0.746179 | 3 | 0 | 3 |
| MCM3AP | SURF6 | 0.74514 | 3 | 0 | 3 |
| MCM3AP | KCNMB4 | 0.743212 | 4 | 0 | 4 |
For details and further investigation, click here
