| Full name: renin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 5972 | HGNC ID: HGNC:9958 | Ensembl Gene: ENSG00000143839 | OMIM ID: 179820 |
| Drug and gene relationship at DGIdb | |||
REN involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04924 | Renin secretion |
Expression of REN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | REN | 5972 | 206367_at | -0.0324 | 0.9307 | |
| GSE20347 | REN | 5972 | 206367_at | -0.1255 | 0.0979 | |
| GSE23400 | REN | 5972 | 206367_at | -0.1590 | 0.0000 | |
| GSE26886 | REN | 5972 | 206367_at | -0.1788 | 0.1185 | |
| GSE29001 | REN | 5972 | 206367_at | -0.2002 | 0.2112 | |
| GSE38129 | REN | 5972 | 206367_at | -0.1315 | 0.0336 | |
| GSE45670 | REN | 5972 | 206367_at | -0.0107 | 0.9479 | |
| GSE53622 | REN | 5972 | 48403 | -0.0165 | 0.8287 | |
| GSE53624 | REN | 5972 | 48403 | -0.1379 | 0.1291 | |
| GSE63941 | REN | 5972 | 206367_at | 0.1662 | 0.3760 | |
| GSE77861 | REN | 5972 | 206367_at | -0.1310 | 0.2428 | |
| GSE97050 | REN | 5972 | A_23_P34637 | -0.0627 | 0.8255 | |
| TCGA | REN | 5972 | RNAseq | 1.8196 | 0.1305 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by REN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of REN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | REN | 5972 | 11 | 0 | 19 | |
| GSE20123 | REN | 5972 | 11 | 0 | 19 | |
| GSE43470 | REN | 5972 | 6 | 0 | 37 | |
| GSE46452 | REN | 5972 | 3 | 1 | 55 | |
| GSE47630 | REN | 5972 | 14 | 0 | 26 | |
| GSE54993 | REN | 5972 | 0 | 6 | 64 | |
| GSE54994 | REN | 5972 | 15 | 0 | 38 | |
| GSE60625 | REN | 5972 | 0 | 0 | 11 | |
| GSE74703 | REN | 5972 | 6 | 0 | 30 | |
| GSE74704 | REN | 5972 | 5 | 0 | 15 | |
| TCGA | REN | 5972 | 43 | 4 | 49 |
Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.
Somatic mutations of REN:
Generating mutation plots.
Highly correlated genes for REN:
Showing top 20/583 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| REN | KCTD19 | 0.796363 | 3 | 0 | 3 |
| REN | STRC | 0.7598 | 3 | 0 | 3 |
| REN | SUN5 | 0.741379 | 3 | 0 | 3 |
| REN | C1QL2 | 0.735515 | 3 | 0 | 3 |
| REN | ATXN7L2 | 0.733724 | 3 | 0 | 3 |
| REN | CHMP6 | 0.729528 | 4 | 0 | 4 |
| REN | BSX | 0.727903 | 3 | 0 | 3 |
| REN | ZC3H10 | 0.711867 | 4 | 0 | 4 |
| REN | CLRN2 | 0.710661 | 3 | 0 | 3 |
| REN | SHISA7 | 0.709598 | 3 | 0 | 3 |
| REN | C9orf153 | 0.70949 | 3 | 0 | 3 |
| REN | ODF3L2 | 0.708424 | 3 | 0 | 3 |
| REN | PRSS38 | 0.708311 | 3 | 0 | 3 |
| REN | FOXA3 | 0.706237 | 3 | 0 | 3 |
| REN | BEST3 | 0.702309 | 3 | 0 | 3 |
| REN | DEFB128 | 0.702176 | 3 | 0 | 3 |
| REN | ANKRD33B | 0.698418 | 3 | 0 | 3 |
| REN | SYPL2 | 0.696273 | 3 | 0 | 3 |
| REN | PABPN1L | 0.69493 | 3 | 0 | 3 |
| REN | DCDC1 | 0.692416 | 3 | 0 | 3 |
For details and further investigation, click here
