| Full name: charged multivesicular body protein 6 | Alias Symbol: FLJ11749|VPS20 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 79643 | HGNC ID: HGNC:25675 | Ensembl Gene: ENSG00000176108 | OMIM ID: 610901 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CHMP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHMP6 | 79643 | 218743_at | 0.1659 | 0.6084 | |
| GSE20347 | CHMP6 | 79643 | 218743_at | -0.2201 | 0.0518 | |
| GSE23400 | CHMP6 | 79643 | 218743_at | -0.0461 | 0.4261 | |
| GSE26886 | CHMP6 | 79643 | 218743_at | -0.0691 | 0.5756 | |
| GSE29001 | CHMP6 | 79643 | 218743_at | -0.3188 | 0.1058 | |
| GSE38129 | CHMP6 | 79643 | 218743_at | -0.1152 | 0.1850 | |
| GSE45670 | CHMP6 | 79643 | 218743_at | -0.0832 | 0.3607 | |
| GSE53622 | CHMP6 | 79643 | 104591 | 0.0554 | 0.3038 | |
| GSE53624 | CHMP6 | 79643 | 104591 | -0.0344 | 0.6184 | |
| GSE63941 | CHMP6 | 79643 | 218743_at | -0.2048 | 0.4625 | |
| GSE77861 | CHMP6 | 79643 | 218743_at | -0.0146 | 0.9481 | |
| GSE97050 | CHMP6 | 79643 | A_23_P10156 | -0.0956 | 0.6114 | |
| SRP007169 | CHMP6 | 79643 | RNAseq | -1.5523 | 0.0001 | |
| SRP008496 | CHMP6 | 79643 | RNAseq | -1.0531 | 0.0007 | |
| SRP064894 | CHMP6 | 79643 | RNAseq | 0.0537 | 0.8741 | |
| SRP133303 | CHMP6 | 79643 | RNAseq | -0.2659 | 0.1381 | |
| SRP159526 | CHMP6 | 79643 | RNAseq | -0.0137 | 0.9576 | |
| SRP193095 | CHMP6 | 79643 | RNAseq | -0.1766 | 0.1613 | |
| SRP219564 | CHMP6 | 79643 | RNAseq | -0.3578 | 0.2592 | |
| TCGA | CHMP6 | 79643 | RNAseq | -0.0076 | 0.9072 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CHMP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHMP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHMP6 | 79643 | 4 | 4 | 22 | |
| GSE20123 | CHMP6 | 79643 | 4 | 4 | 22 | |
| GSE43470 | CHMP6 | 79643 | 3 | 5 | 35 | |
| GSE46452 | CHMP6 | 79643 | 34 | 0 | 25 | |
| GSE47630 | CHMP6 | 79643 | 9 | 2 | 29 | |
| GSE54993 | CHMP6 | 79643 | 2 | 5 | 63 | |
| GSE54994 | CHMP6 | 79643 | 10 | 6 | 37 | |
| GSE60625 | CHMP6 | 79643 | 6 | 0 | 5 | |
| GSE74703 | CHMP6 | 79643 | 3 | 3 | 30 | |
| GSE74704 | CHMP6 | 79643 | 4 | 3 | 13 | |
| TCGA | CHMP6 | 79643 | 27 | 13 | 56 |
Total number of gains: 106; Total number of losses: 45; Total Number of normals: 337.
Somatic mutations of CHMP6:
Generating mutation plots.
Highly correlated genes for CHMP6:
Showing top 20/373 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHMP6 | PVALB | 0.863454 | 3 | 0 | 3 |
| CHMP6 | DCDC1 | 0.8538 | 3 | 0 | 3 |
| CHMP6 | SLC39A5 | 0.848276 | 4 | 0 | 4 |
| CHMP6 | SUN5 | 0.845024 | 3 | 0 | 3 |
| CHMP6 | ESPNL | 0.842112 | 3 | 0 | 3 |
| CHMP6 | TMUB1 | 0.827214 | 3 | 0 | 3 |
| CHMP6 | STRC | 0.8166 | 3 | 0 | 3 |
| CHMP6 | TSPAN11 | 0.815736 | 3 | 0 | 3 |
| CHMP6 | AGRP | 0.781772 | 3 | 0 | 3 |
| CHMP6 | PLA2G2C | 0.778507 | 3 | 0 | 3 |
| CHMP6 | DBX1 | 0.777209 | 3 | 0 | 3 |
| CHMP6 | DEFB121 | 0.776991 | 3 | 0 | 3 |
| CHMP6 | CHD5 | 0.77559 | 4 | 0 | 4 |
| CHMP6 | C1QL2 | 0.774491 | 3 | 0 | 3 |
| CHMP6 | SIGIRR | 0.772258 | 3 | 0 | 3 |
| CHMP6 | OR2H1 | 0.771307 | 3 | 0 | 3 |
| CHMP6 | OR2T27 | 0.76729 | 3 | 0 | 3 |
| CHMP6 | SLC4A1 | 0.765282 | 3 | 0 | 3 |
| CHMP6 | KCP | 0.765151 | 4 | 0 | 4 |
| CHMP6 | PABPN1L | 0.759178 | 3 | 0 | 3 |
For details and further investigation, click here
