| Full name: bestrophin 3 | Alias Symbol: MGC40411|MGC13168 | ||
| Type: protein-coding gene | Cytoband: 12q15 | ||
| Entrez ID: 144453 | HGNC ID: HGNC:17105 | Ensembl Gene: ENSG00000127325 | OMIM ID: 607337 |
| Drug and gene relationship at DGIdb | |||
Expression of BEST3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BEST3 | 144453 | 237003_at | 0.0281 | 0.9011 | |
| GSE26886 | BEST3 | 144453 | 237003_at | 0.1945 | 0.0763 | |
| GSE45670 | BEST3 | 144453 | 237003_at | 0.1125 | 0.1926 | |
| GSE53622 | BEST3 | 144453 | 11582 | 0.0933 | 0.2860 | |
| GSE53624 | BEST3 | 144453 | 11582 | -0.8712 | 0.0000 | |
| GSE63941 | BEST3 | 144453 | 237003_at | 0.0251 | 0.8967 | |
| GSE77861 | BEST3 | 144453 | 237003_at | -0.0241 | 0.8582 | |
| GSE97050 | BEST3 | 144453 | A_33_P3249877 | 0.1283 | 0.5687 | |
| SRP133303 | BEST3 | 144453 | RNAseq | -0.3039 | 0.0152 | |
| SRP159526 | BEST3 | 144453 | RNAseq | -0.5259 | 0.2493 | |
| SRP193095 | BEST3 | 144453 | RNAseq | -0.3969 | 0.0165 | |
| SRP219564 | BEST3 | 144453 | RNAseq | -1.2660 | 0.0388 | |
| TCGA | BEST3 | 144453 | RNAseq | 3.2035 | 0.0027 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by BEST3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BEST3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BEST3 | 144453 | 6 | 1 | 23 | |
| GSE20123 | BEST3 | 144453 | 6 | 0 | 24 | |
| GSE43470 | BEST3 | 144453 | 4 | 0 | 39 | |
| GSE46452 | BEST3 | 144453 | 10 | 1 | 48 | |
| GSE47630 | BEST3 | 144453 | 10 | 1 | 29 | |
| GSE54993 | BEST3 | 144453 | 0 | 6 | 64 | |
| GSE54994 | BEST3 | 144453 | 8 | 1 | 44 | |
| GSE60625 | BEST3 | 144453 | 0 | 0 | 11 | |
| GSE74703 | BEST3 | 144453 | 4 | 0 | 32 | |
| GSE74704 | BEST3 | 144453 | 5 | 0 | 15 | |
| TCGA | BEST3 | 144453 | 23 | 8 | 65 |
Total number of gains: 76; Total number of losses: 18; Total Number of normals: 394.
Somatic mutations of BEST3:
Generating mutation plots.
Highly correlated genes for BEST3:
Showing top 20/358 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BEST3 | CLRN2 | 0.780775 | 3 | 0 | 3 |
| BEST3 | KCTD19 | 0.774642 | 4 | 0 | 4 |
| BEST3 | CELF4 | 0.747876 | 3 | 0 | 3 |
| BEST3 | PIK3C2B | 0.741948 | 3 | 0 | 3 |
| BEST3 | MIIP | 0.739058 | 3 | 0 | 3 |
| BEST3 | C7orf61 | 0.736239 | 3 | 0 | 3 |
| BEST3 | DSCAM | 0.728385 | 3 | 0 | 3 |
| BEST3 | WNT9A | 0.722379 | 3 | 0 | 3 |
| BEST3 | GPR152 | 0.72081 | 3 | 0 | 3 |
| BEST3 | HTR6 | 0.720152 | 3 | 0 | 3 |
| BEST3 | KRTAP9-1 | 0.719055 | 3 | 0 | 3 |
| BEST3 | GRIK4 | 0.717968 | 3 | 0 | 3 |
| BEST3 | CLDN14 | 0.713661 | 3 | 0 | 3 |
| BEST3 | RHPN1 | 0.713069 | 3 | 0 | 3 |
| BEST3 | PGLYRP1 | 0.71094 | 3 | 0 | 3 |
| BEST3 | SLC22A31 | 0.710604 | 4 | 0 | 4 |
| BEST3 | CD72 | 0.708351 | 3 | 0 | 3 |
| BEST3 | RUFY4 | 0.706551 | 3 | 0 | 3 |
| BEST3 | CD70 | 0.704619 | 3 | 0 | 3 |
| BEST3 | REN | 0.702309 | 3 | 0 | 3 |
For details and further investigation, click here
