| Full name: regulator of G protein signaling 9 | Alias Symbol: PERRS|RGS9L|MGC26458|MGC111763 | ||
| Type: protein-coding gene | Cytoband: 17q24.1 | ||
| Entrez ID: 8787 | HGNC ID: HGNC:10004 | Ensembl Gene: ENSG00000108370 | OMIM ID: 604067 |
| Drug and gene relationship at DGIdb | |||
RGS9 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05030 | Cocaine addiction |
Expression of RGS9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RGS9 | 8787 | 206518_s_at | -0.3177 | 0.6545 | |
| GSE20347 | RGS9 | 8787 | 206518_s_at | 0.0027 | 0.9743 | |
| GSE23400 | RGS9 | 8787 | 206518_s_at | -0.0852 | 0.0068 | |
| GSE26886 | RGS9 | 8787 | 206518_s_at | 0.3566 | 0.0408 | |
| GSE29001 | RGS9 | 8787 | 206518_s_at | 0.0540 | 0.6622 | |
| GSE38129 | RGS9 | 8787 | 206518_s_at | -0.2657 | 0.0903 | |
| GSE45670 | RGS9 | 8787 | 206518_s_at | -0.1685 | 0.0947 | |
| GSE53622 | RGS9 | 8787 | 69560 | -0.6860 | 0.0000 | |
| GSE53624 | RGS9 | 8787 | 69560 | -0.4563 | 0.0001 | |
| GSE63941 | RGS9 | 8787 | 206518_s_at | -0.1046 | 0.5112 | |
| GSE77861 | RGS9 | 8787 | 206518_s_at | 0.0058 | 0.9672 | |
| GSE97050 | RGS9 | A_21_P0000057 | -0.5388 | 0.4257 | ||
| SRP064894 | RGS9 | 8787 | RNAseq | -0.5067 | 0.1540 | |
| SRP133303 | RGS9 | 8787 | RNAseq | 0.2492 | 0.6169 | |
| SRP219564 | RGS9 | 8787 | RNAseq | -0.9154 | 0.2825 | |
| TCGA | RGS9 | 8787 | RNAseq | -0.7881 | 0.0230 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RGS9 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RGS9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RGS9 | 8787 | 3 | 1 | 26 | |
| GSE20123 | RGS9 | 8787 | 3 | 1 | 26 | |
| GSE43470 | RGS9 | 8787 | 5 | 0 | 38 | |
| GSE46452 | RGS9 | 8787 | 32 | 0 | 27 | |
| GSE47630 | RGS9 | 8787 | 7 | 1 | 32 | |
| GSE54993 | RGS9 | 8787 | 2 | 5 | 63 | |
| GSE54994 | RGS9 | 8787 | 9 | 4 | 40 | |
| GSE60625 | RGS9 | 8787 | 4 | 0 | 7 | |
| GSE74703 | RGS9 | 8787 | 5 | 0 | 31 | |
| GSE74704 | RGS9 | 8787 | 3 | 1 | 16 | |
| TCGA | RGS9 | 8787 | 30 | 8 | 58 |
Total number of gains: 103; Total number of losses: 21; Total Number of normals: 364.
Somatic mutations of RGS9:
Generating mutation plots.
Highly correlated genes for RGS9:
Showing top 20/847 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RGS9 | CORO6 | 0.825612 | 3 | 0 | 3 |
| RGS9 | ARHGEF25 | 0.771873 | 3 | 0 | 3 |
| RGS9 | CYS1 | 0.751966 | 5 | 0 | 4 |
| RGS9 | KLHL23 | 0.745117 | 3 | 0 | 3 |
| RGS9 | RBM24 | 0.744403 | 3 | 0 | 3 |
| RGS9 | IGIP | 0.738393 | 3 | 0 | 3 |
| RGS9 | KLF11 | 0.735116 | 3 | 0 | 3 |
| RGS9 | TLN1 | 0.734146 | 5 | 0 | 5 |
| RGS9 | IQUB | 0.731111 | 3 | 0 | 3 |
| RGS9 | SLC26A10 | 0.722854 | 6 | 0 | 6 |
| RGS9 | FGF12 | 0.722521 | 3 | 0 | 3 |
| RGS9 | KL | 0.722473 | 3 | 0 | 3 |
| RGS9 | ARMCX1 | 0.720064 | 4 | 0 | 4 |
| RGS9 | TMOD1 | 0.717492 | 7 | 0 | 6 |
| RGS9 | ARHGAP6 | 0.711618 | 6 | 0 | 5 |
| RGS9 | CORO2B | 0.705356 | 6 | 0 | 6 |
| RGS9 | FNDC5 | 0.703961 | 4 | 0 | 3 |
| RGS9 | RRAS | 0.703584 | 6 | 0 | 6 |
| RGS9 | MYADM | 0.700971 | 4 | 0 | 3 |
| RGS9 | RGMB | 0.7009 | 4 | 0 | 3 |
For details and further investigation, click here
