| Full name: Rho guanine nucleotide exchange factor 25 | Alias Symbol: GEFT|p63RhoGEF | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 115557 | HGNC ID: HGNC:30275 | Ensembl Gene: ENSG00000240771 | OMIM ID: 610215 |
| Drug and gene relationship at DGIdb | |||
Expression of ARHGEF25:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF25 | 115557 | 227427_at | -0.3556 | 0.4870 | |
| GSE26886 | ARHGEF25 | 115557 | 227427_at | 0.0015 | 0.9935 | |
| GSE45670 | ARHGEF25 | 115557 | 227427_at | -0.4158 | 0.0002 | |
| GSE53622 | ARHGEF25 | 115557 | 93970 | -0.4640 | 0.0028 | |
| GSE53624 | ARHGEF25 | 115557 | 16998 | -0.4991 | 0.0001 | |
| GSE63941 | ARHGEF25 | 115557 | 227427_at | 0.0916 | 0.7225 | |
| GSE77861 | ARHGEF25 | 115557 | 227427_at | -0.1616 | 0.1876 | |
| GSE97050 | ARHGEF25 | 115557 | A_24_P289299 | -1.0289 | 0.1440 | |
| SRP007169 | ARHGEF25 | 115557 | RNAseq | 4.8848 | 0.0007 | |
| SRP064894 | ARHGEF25 | 115557 | RNAseq | -0.0025 | 0.9937 | |
| SRP133303 | ARHGEF25 | 115557 | RNAseq | -0.3829 | 0.3169 | |
| SRP159526 | ARHGEF25 | 115557 | RNAseq | -0.2334 | 0.5655 | |
| SRP193095 | ARHGEF25 | 115557 | RNAseq | 1.1324 | 0.0000 | |
| SRP219564 | ARHGEF25 | 115557 | RNAseq | -0.7196 | 0.3813 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ARHGEF25 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ARHGEF25:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF25 | 115557 | 7 | 1 | 22 | |
| GSE20123 | ARHGEF25 | 115557 | 7 | 0 | 23 | |
| GSE43470 | ARHGEF25 | 115557 | 2 | 0 | 41 | |
| GSE46452 | ARHGEF25 | 115557 | 8 | 1 | 50 | |
| GSE47630 | ARHGEF25 | 115557 | 10 | 2 | 28 | |
| GSE54993 | ARHGEF25 | 115557 | 0 | 5 | 65 | |
| GSE54994 | ARHGEF25 | 115557 | 4 | 1 | 48 | |
| GSE60625 | ARHGEF25 | 115557 | 0 | 0 | 11 | |
| GSE74703 | ARHGEF25 | 115557 | 2 | 0 | 34 | |
| GSE74704 | ARHGEF25 | 115557 | 5 | 0 | 15 | |
| TCGA | ARHGEF25 | 115557 | 14 | 10 | 72 |
Total number of gains: 59; Total number of losses: 20; Total Number of normals: 409.
Somatic mutations of ARHGEF25:
Generating mutation plots.
Highly correlated genes for ARHGEF25:
Showing top 20/649 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF25 | ACACB | 0.829748 | 3 | 0 | 3 |
| ARHGEF25 | PLA2G5 | 0.781911 | 4 | 0 | 4 |
| ARHGEF25 | IQUB | 0.780339 | 3 | 0 | 3 |
| ARHGEF25 | SOX10 | 0.780138 | 3 | 0 | 3 |
| ARHGEF25 | KIAA0408 | 0.776077 | 3 | 0 | 3 |
| ARHGEF25 | RGS9 | 0.771873 | 3 | 0 | 3 |
| ARHGEF25 | EPHA7 | 0.758436 | 3 | 0 | 3 |
| ARHGEF25 | PLP1 | 0.74135 | 4 | 0 | 4 |
| ARHGEF25 | PDZRN4 | 0.74062 | 6 | 0 | 6 |
| ARHGEF25 | NEXN | 0.73887 | 5 | 0 | 5 |
| ARHGEF25 | RYR2 | 0.729799 | 5 | 0 | 4 |
| ARHGEF25 | MYEF2 | 0.727334 | 4 | 0 | 4 |
| ARHGEF25 | SMAD9 | 0.723344 | 5 | 0 | 5 |
| ARHGEF25 | TPM2 | 0.721522 | 5 | 0 | 5 |
| ARHGEF25 | ARHGEF10 | 0.720805 | 3 | 0 | 3 |
| ARHGEF25 | CACNB2 | 0.719939 | 5 | 0 | 5 |
| ARHGEF25 | TNIK | 0.719622 | 4 | 0 | 4 |
| ARHGEF25 | PBX1 | 0.71751 | 4 | 0 | 4 |
| ARHGEF25 | KCNMB1 | 0.717412 | 5 | 0 | 4 |
| ARHGEF25 | PGR | 0.7159 | 5 | 0 | 4 |
For details and further investigation, click here
