| Full name: receptor interacting serine/threonine kinase 2 | Alias Symbol: RICK|RIP2|CARDIAK|CARD3 | ||
| Type: protein-coding gene | Cytoband: 8q21.3 | ||
| Entrez ID: 8767 | HGNC ID: HGNC:10020 | Ensembl Gene: ENSG00000104312 | OMIM ID: 603455 |
| Drug and gene relationship at DGIdb | |||
RIPK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04621 | NOD-like receptor signaling pathway | |
| hsa04722 | Neurotrophin signaling pathway | |
| hsa05131 | Shigellosis | |
| hsa05152 | Tuberculosis |
Expression of RIPK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RIPK2 | 8767 | 209545_s_at | 0.3992 | 0.3485 | |
| GSE20347 | RIPK2 | 8767 | 209545_s_at | 0.5217 | 0.0037 | |
| GSE23400 | RIPK2 | 8767 | 209545_s_at | 0.3105 | 0.0000 | |
| GSE26886 | RIPK2 | 8767 | 209545_s_at | 0.8800 | 0.0000 | |
| GSE29001 | RIPK2 | 8767 | 209545_s_at | 0.2173 | 0.3461 | |
| GSE38129 | RIPK2 | 8767 | 209545_s_at | 0.5345 | 0.0003 | |
| GSE45670 | RIPK2 | 8767 | 209545_s_at | 0.3095 | 0.2066 | |
| GSE53622 | RIPK2 | 8767 | 80210 | 0.6934 | 0.0000 | |
| GSE53624 | RIPK2 | 8767 | 80210 | 0.7584 | 0.0000 | |
| GSE63941 | RIPK2 | 8767 | 209545_s_at | 0.4039 | 0.4955 | |
| GSE77861 | RIPK2 | 8767 | 209545_s_at | 0.3862 | 0.0791 | |
| GSE97050 | RIPK2 | 8767 | A_23_P252106 | 0.6340 | 0.1406 | |
| SRP007169 | RIPK2 | 8767 | RNAseq | 0.4587 | 0.2156 | |
| SRP008496 | RIPK2 | 8767 | RNAseq | 0.5794 | 0.0053 | |
| SRP064894 | RIPK2 | 8767 | RNAseq | 0.9705 | 0.0000 | |
| SRP133303 | RIPK2 | 8767 | RNAseq | 1.1850 | 0.0000 | |
| SRP159526 | RIPK2 | 8767 | RNAseq | 0.5401 | 0.0152 | |
| SRP193095 | RIPK2 | 8767 | RNAseq | 0.6652 | 0.0000 | |
| SRP219564 | RIPK2 | 8767 | RNAseq | 0.8254 | 0.0301 | |
| TCGA | RIPK2 | 8767 | RNAseq | 0.2433 | 0.0008 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by RIPK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RIPK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RIPK2 | 8767 | 14 | 1 | 15 | |
| GSE20123 | RIPK2 | 8767 | 15 | 1 | 14 | |
| GSE43470 | RIPK2 | 8767 | 20 | 1 | 22 | |
| GSE46452 | RIPK2 | 8767 | 22 | 0 | 37 | |
| GSE47630 | RIPK2 | 8767 | 23 | 0 | 17 | |
| GSE54993 | RIPK2 | 8767 | 0 | 20 | 50 | |
| GSE54994 | RIPK2 | 8767 | 33 | 1 | 19 | |
| GSE60625 | RIPK2 | 8767 | 0 | 4 | 7 | |
| GSE74703 | RIPK2 | 8767 | 17 | 1 | 18 | |
| GSE74704 | RIPK2 | 8767 | 10 | 0 | 10 | |
| TCGA | RIPK2 | 8767 | 55 | 3 | 38 |
Total number of gains: 209; Total number of losses: 32; Total Number of normals: 247.
Somatic mutations of RIPK2:
Generating mutation plots.
Highly correlated genes for RIPK2:
Showing top 20/809 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RIPK2 | PET117 | 0.702661 | 3 | 0 | 3 |
| RIPK2 | SLC25A32 | 0.699129 | 10 | 0 | 9 |
| RIPK2 | NUMBL | 0.681682 | 3 | 0 | 3 |
| RIPK2 | STMN3 | 0.654674 | 5 | 0 | 3 |
| RIPK2 | IFT43 | 0.654613 | 5 | 0 | 5 |
| RIPK2 | ADAMTS12 | 0.647051 | 6 | 0 | 6 |
| RIPK2 | PXYLP1 | 0.646009 | 4 | 0 | 3 |
| RIPK2 | CD300E | 0.642237 | 3 | 0 | 3 |
| RIPK2 | MAD2L2 | 0.641871 | 5 | 0 | 4 |
| RIPK2 | IL4I1 | 0.639923 | 6 | 0 | 5 |
| RIPK2 | PLA2G7 | 0.639897 | 12 | 0 | 11 |
| RIPK2 | FAM53C | 0.638369 | 3 | 0 | 3 |
| RIPK2 | KRBOX4 | 0.637623 | 3 | 0 | 3 |
| RIPK2 | MMP12 | 0.635698 | 11 | 0 | 10 |
| RIPK2 | PLAUR | 0.634271 | 11 | 0 | 9 |
| RIPK2 | ADAMTS2 | 0.633946 | 6 | 0 | 6 |
| RIPK2 | SLC12A7 | 0.632856 | 5 | 0 | 3 |
| RIPK2 | MTERF3 | 0.630053 | 9 | 0 | 7 |
| RIPK2 | NUDCD1 | 0.628584 | 7 | 0 | 6 |
| RIPK2 | LPCAT1 | 0.628246 | 9 | 0 | 7 |
For details and further investigation, click here
