| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 12 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5p13.3-p13.2 | ||
| Entrez ID: 81792 | HGNC ID: HGNC:14605 | Ensembl Gene: ENSG00000151388 | OMIM ID: 606184 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS12 | 81792 | 226997_at | 2.3297 | 0.0308 | |
| GSE20347 | ADAMTS12 | 81792 | 221421_s_at | 0.0116 | 0.9230 | |
| GSE23400 | ADAMTS12 | 81792 | 221421_s_at | -0.0844 | 0.0289 | |
| GSE26886 | ADAMTS12 | 81792 | 226997_at | 1.3345 | 0.0003 | |
| GSE29001 | ADAMTS12 | 81792 | 221421_s_at | -0.1464 | 0.3608 | |
| GSE38129 | ADAMTS12 | 81792 | 221421_s_at | -0.0522 | 0.5717 | |
| GSE45670 | ADAMTS12 | 81792 | 226997_at | 1.1421 | 0.0068 | |
| GSE53622 | ADAMTS12 | 81792 | 47121 | 4.2917 | 0.0000 | |
| GSE53624 | ADAMTS12 | 81792 | 47121 | 4.1705 | 0.0000 | |
| GSE63941 | ADAMTS12 | 81792 | 226997_at | -2.8070 | 0.0003 | |
| GSE77861 | ADAMTS12 | 81792 | 226997_at | 0.3261 | 0.3255 | |
| GSE97050 | ADAMTS12 | 81792 | A_23_P44648 | 2.6725 | 0.0465 | |
| SRP007169 | ADAMTS12 | 81792 | RNAseq | 5.6641 | 0.0000 | |
| SRP008496 | ADAMTS12 | 81792 | RNAseq | 6.2117 | 0.0000 | |
| SRP064894 | ADAMTS12 | 81792 | RNAseq | 3.0784 | 0.0000 | |
| SRP133303 | ADAMTS12 | 81792 | RNAseq | 3.5605 | 0.0000 | |
| SRP159526 | ADAMTS12 | 81792 | RNAseq | 2.0689 | 0.0000 | |
| SRP193095 | ADAMTS12 | 81792 | RNAseq | 4.0162 | 0.0000 | |
| SRP219564 | ADAMTS12 | 81792 | RNAseq | 1.1270 | 0.2753 | |
| TCGA | ADAMTS12 | 81792 | RNAseq | 1.4697 | 0.0000 |
Upregulated datasets: 13; Downregulated datasets: 1.
Survival by ADAMTS12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS12 | 81792 | 11 | 0 | 19 | |
| GSE20123 | ADAMTS12 | 81792 | 11 | 0 | 19 | |
| GSE43470 | ADAMTS12 | 81792 | 15 | 3 | 25 | |
| GSE46452 | ADAMTS12 | 81792 | 6 | 21 | 32 | |
| GSE47630 | ADAMTS12 | 81792 | 6 | 12 | 22 | |
| GSE54993 | ADAMTS12 | 81792 | 5 | 4 | 61 | |
| GSE54994 | ADAMTS12 | 81792 | 26 | 2 | 25 | |
| GSE60625 | ADAMTS12 | 81792 | 0 | 0 | 11 | |
| GSE74703 | ADAMTS12 | 81792 | 12 | 2 | 22 | |
| GSE74704 | ADAMTS12 | 81792 | 10 | 0 | 10 | |
| TCGA | ADAMTS12 | 81792 | 51 | 6 | 39 |
Total number of gains: 153; Total number of losses: 50; Total Number of normals: 285.
Somatic mutations of ADAMTS12:
Generating mutation plots.
Highly correlated genes for ADAMTS12:
Showing top 20/1044 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS12 | ALPK2 | 0.830125 | 3 | 0 | 3 |
| ADAMTS12 | MMP11 | 0.827698 | 6 | 0 | 6 |
| ADAMTS12 | CTHRC1 | 0.82665 | 8 | 0 | 8 |
| ADAMTS12 | BGN | 0.826355 | 8 | 0 | 8 |
| ADAMTS12 | FAP | 0.821195 | 6 | 0 | 6 |
| ADAMTS12 | LRRC15 | 0.820529 | 7 | 0 | 7 |
| ADAMTS12 | COL11A1 | 0.81584 | 7 | 0 | 7 |
| ADAMTS12 | ADAMTS2 | 0.814333 | 7 | 0 | 6 |
| ADAMTS12 | COL1A1 | 0.810254 | 9 | 0 | 9 |
| ADAMTS12 | ZNF469 | 0.80687 | 8 | 0 | 7 |
| ADAMTS12 | COL10A1 | 0.805551 | 8 | 0 | 7 |
| ADAMTS12 | TTYH3 | 0.798708 | 7 | 0 | 7 |
| ADAMTS12 | SERPINE1 | 0.785285 | 8 | 0 | 8 |
| ADAMTS12 | MMP1 | 0.784307 | 8 | 0 | 8 |
| ADAMTS12 | PLAU | 0.783752 | 7 | 0 | 7 |
| ADAMTS12 | PDIA5 | 0.766213 | 3 | 0 | 3 |
| ADAMTS12 | EDA2R | 0.766123 | 4 | 0 | 4 |
| ADAMTS12 | CHRM2 | 0.757779 | 5 | 0 | 5 |
| ADAMTS12 | KIR3DL3 | 0.756201 | 5 | 0 | 5 |
| ADAMTS12 | SPON2 | 0.7546 | 3 | 0 | 3 |
For details and further investigation, click here
