| Full name: matrix metallopeptidase 12 | Alias Symbol: HME | ||
| Type: protein-coding gene | Cytoband: 11q22.2 | ||
| Entrez ID: 4321 | HGNC ID: HGNC:7158 | Ensembl Gene: ENSG00000262406 | OMIM ID: 601046 |
| Drug and gene relationship at DGIdb | |||
Expression of MMP12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP12 | 4321 | 204580_at | 4.0380 | 0.0703 | |
| GSE20347 | MMP12 | 4321 | 204580_at | 3.6996 | 0.0000 | |
| GSE23400 | MMP12 | 4321 | 204580_at | 2.4036 | 0.0000 | |
| GSE26886 | MMP12 | 4321 | 204580_at | 3.1114 | 0.0017 | |
| GSE29001 | MMP12 | 4321 | 204580_at | 2.3475 | 0.0001 | |
| GSE38129 | MMP12 | 4321 | 204580_at | 3.9830 | 0.0000 | |
| GSE45670 | MMP12 | 4321 | 204580_at | 4.9454 | 0.0000 | |
| GSE53622 | MMP12 | 4321 | 30773 | 4.1745 | 0.0000 | |
| GSE53624 | MMP12 | 4321 | 30773 | 4.1417 | 0.0000 | |
| GSE63941 | MMP12 | 4321 | 204580_at | -2.6051 | 0.0649 | |
| GSE77861 | MMP12 | 4321 | 204580_at | 3.7442 | 0.0009 | |
| GSE97050 | MMP12 | 4321 | A_23_P150316 | 1.9423 | 0.0555 | |
| SRP007169 | MMP12 | 4321 | RNAseq | 9.1829 | 0.0000 | |
| SRP008496 | MMP12 | 4321 | RNAseq | 7.4098 | 0.0000 | |
| SRP133303 | MMP12 | 4321 | RNAseq | 5.0101 | 0.0000 | |
| SRP159526 | MMP12 | 4321 | RNAseq | 4.8077 | 0.0000 | |
| SRP193095 | MMP12 | 4321 | RNAseq | 4.1066 | 0.0000 | |
| SRP219564 | MMP12 | 4321 | RNAseq | 4.9180 | 0.0000 | |
| TCGA | MMP12 | 4321 | RNAseq | 2.5436 | 0.0000 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by MMP12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP12 | 4321 | 4 | 8 | 18 | |
| GSE20123 | MMP12 | 4321 | 5 | 8 | 17 | |
| GSE43470 | MMP12 | 4321 | 5 | 5 | 33 | |
| GSE46452 | MMP12 | 4321 | 5 | 24 | 30 | |
| GSE47630 | MMP12 | 4321 | 2 | 19 | 19 | |
| GSE54993 | MMP12 | 4321 | 9 | 1 | 60 | |
| GSE54994 | MMP12 | 4321 | 6 | 18 | 29 | |
| GSE60625 | MMP12 | 4321 | 0 | 3 | 8 | |
| GSE74703 | MMP12 | 4321 | 3 | 4 | 29 | |
| GSE74704 | MMP12 | 4321 | 5 | 4 | 11 | |
| TCGA | MMP12 | 4321 | 10 | 44 | 42 |
Total number of gains: 54; Total number of losses: 138; Total Number of normals: 296.
Somatic mutations of MMP12:
Generating mutation plots.
Highly correlated genes for MMP12:
Showing top 20/1782 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP12 | MMP1 | 0.810831 | 13 | 0 | 13 |
| MMP12 | XPR1 | 0.798313 | 7 | 0 | 7 |
| MMP12 | KIF14 | 0.777235 | 11 | 0 | 11 |
| MMP12 | NOP56 | 0.777056 | 3 | 0 | 3 |
| MMP12 | CTHRC1 | 0.775652 | 8 | 0 | 7 |
| MMP12 | CXCL8 | 0.774486 | 10 | 0 | 10 |
| MMP12 | PLA2G7 | 0.774365 | 12 | 0 | 11 |
| MMP12 | AURKA | 0.77251 | 11 | 0 | 11 |
| MMP12 | DCBLD1 | 0.770995 | 7 | 0 | 7 |
| MMP12 | ECT2 | 0.770156 | 11 | 0 | 11 |
| MMP12 | TTYH3 | 0.769751 | 7 | 0 | 7 |
| MMP12 | FAM89A | 0.768745 | 3 | 0 | 3 |
| MMP12 | PDIA5 | 0.767419 | 3 | 0 | 3 |
| MMP12 | MARCKSL1 | 0.763381 | 11 | 0 | 10 |
| MMP12 | FANCB | 0.762963 | 5 | 0 | 5 |
| MMP12 | LPCAT1 | 0.762537 | 11 | 0 | 11 |
| MMP12 | MET | 0.759629 | 11 | 0 | 10 |
| MMP12 | CDC25B | 0.759472 | 11 | 0 | 11 |
| MMP12 | UBE2C | 0.758351 | 11 | 0 | 11 |
| MMP12 | SPP1 | 0.758035 | 11 | 0 | 11 |
For details and further investigation, click here
