| Full name: mitotic arrest deficient 2 like 2 | Alias Symbol: MAD2B|REV7|POLZ2|FANCV | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 10459 | HGNC ID: HGNC:6764 | Ensembl Gene: ENSG00000116670 | OMIM ID: 604094 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
MAD2L2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation |
Expression of MAD2L2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAD2L2 | 10459 | 223234_at | 1.0648 | 0.1180 | |
| GSE26886 | MAD2L2 | 10459 | 223234_at | 0.8553 | 0.0055 | |
| GSE45670 | MAD2L2 | 10459 | 223234_at | 0.4758 | 0.0854 | |
| GSE53622 | MAD2L2 | 10459 | 37671 | 1.3438 | 0.0000 | |
| GSE53624 | MAD2L2 | 10459 | 37671 | 1.6242 | 0.0000 | |
| GSE63941 | MAD2L2 | 10459 | 223234_at | 1.7601 | 0.0026 | |
| GSE77861 | MAD2L2 | 10459 | 223234_at | 0.1285 | 0.5372 | |
| GSE97050 | MAD2L2 | 10459 | A_23_P23206 | 0.6368 | 0.1845 | |
| SRP007169 | MAD2L2 | 10459 | RNAseq | 1.1528 | 0.0268 | |
| SRP008496 | MAD2L2 | 10459 | RNAseq | 1.2906 | 0.0004 | |
| SRP064894 | MAD2L2 | 10459 | RNAseq | 1.6967 | 0.0000 | |
| SRP133303 | MAD2L2 | 10459 | RNAseq | 1.5265 | 0.0000 | |
| SRP159526 | MAD2L2 | 10459 | RNAseq | 1.9755 | 0.0001 | |
| SRP193095 | MAD2L2 | 10459 | RNAseq | 1.4818 | 0.0000 | |
| SRP219564 | MAD2L2 | 10459 | RNAseq | 0.7991 | 0.0446 | |
| TCGA | MAD2L2 | 10459 | RNAseq | 0.3620 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by MAD2L2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAD2L2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAD2L2 | 10459 | 0 | 5 | 25 | |
| GSE20123 | MAD2L2 | 10459 | 0 | 4 | 26 | |
| GSE43470 | MAD2L2 | 10459 | 5 | 5 | 33 | |
| GSE46452 | MAD2L2 | 10459 | 7 | 1 | 51 | |
| GSE47630 | MAD2L2 | 10459 | 8 | 4 | 28 | |
| GSE54993 | MAD2L2 | 10459 | 3 | 1 | 66 | |
| GSE54994 | MAD2L2 | 10459 | 11 | 4 | 38 | |
| GSE60625 | MAD2L2 | 10459 | 0 | 0 | 11 | |
| GSE74703 | MAD2L2 | 10459 | 4 | 3 | 29 | |
| GSE74704 | MAD2L2 | 10459 | 0 | 0 | 20 | |
| TCGA | MAD2L2 | 10459 | 10 | 23 | 63 |
Total number of gains: 48; Total number of losses: 50; Total Number of normals: 390.
Somatic mutations of MAD2L2:
Generating mutation plots.
Highly correlated genes for MAD2L2:
Showing top 20/1922 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAD2L2 | INTS10 | 0.865357 | 3 | 0 | 3 |
| MAD2L2 | RAB34 | 0.818721 | 3 | 0 | 3 |
| MAD2L2 | SLC35B2 | 0.807665 | 3 | 0 | 3 |
| MAD2L2 | PYCR2 | 0.799816 | 3 | 0 | 3 |
| MAD2L2 | NFKB1 | 0.79342 | 3 | 0 | 3 |
| MAD2L2 | SRSF10 | 0.78745 | 4 | 0 | 4 |
| MAD2L2 | MTHFD1L | 0.786839 | 3 | 0 | 3 |
| MAD2L2 | SNAP47 | 0.781136 | 3 | 0 | 3 |
| MAD2L2 | NAP1L1 | 0.780189 | 3 | 0 | 3 |
| MAD2L2 | ZNF251 | 0.780002 | 3 | 0 | 3 |
| MAD2L2 | KDM1A | 0.768568 | 7 | 0 | 7 |
| MAD2L2 | EMC1 | 0.764332 | 5 | 0 | 5 |
| MAD2L2 | FADS1 | 0.763568 | 3 | 0 | 3 |
| MAD2L2 | MAST1 | 0.762124 | 3 | 0 | 3 |
| MAD2L2 | FCGR3A | 0.760329 | 3 | 0 | 3 |
| MAD2L2 | PDIA5 | 0.759404 | 3 | 0 | 3 |
| MAD2L2 | CEBPB | 0.759004 | 4 | 0 | 4 |
| MAD2L2 | LRRC8C | 0.754546 | 3 | 0 | 3 |
| MAD2L2 | SCNM1 | 0.753926 | 3 | 0 | 3 |
| MAD2L2 | HSPA5 | 0.752516 | 3 | 0 | 3 |
For details and further investigation, click here
