| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 2 | Alias Symbol: ADAMTS-3|hPCPNI|PCINP|ADAM-TS2|NPI | ||
| Type: protein-coding gene | Cytoband: 5q35.3 | ||
| Entrez ID: 9509 | HGNC ID: HGNC:218 | Ensembl Gene: ENSG00000087116 | OMIM ID: 604539 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS2 | 9509 | 226311_at | 2.3381 | 0.0596 | |
| GSE20347 | ADAMTS2 | 9509 | 214454_at | 0.2677 | 0.0291 | |
| GSE23400 | ADAMTS2 | 9509 | 214454_at | 0.1227 | 0.0524 | |
| GSE26886 | ADAMTS2 | 9509 | 226311_at | 2.3024 | 0.0000 | |
| GSE29001 | ADAMTS2 | 9509 | 214535_s_at | 0.1215 | 0.6004 | |
| GSE38129 | ADAMTS2 | 9509 | 214454_at | 0.0822 | 0.6381 | |
| GSE45670 | ADAMTS2 | 9509 | 226311_at | 1.4328 | 0.0218 | |
| GSE53622 | ADAMTS2 | 9509 | 81203 | 2.9130 | 0.0000 | |
| GSE53624 | ADAMTS2 | 9509 | 35016 | 3.3437 | 0.0000 | |
| GSE63941 | ADAMTS2 | 9509 | 214535_s_at | -0.4365 | 0.2013 | |
| GSE77861 | ADAMTS2 | 9509 | 214535_s_at | 0.1465 | 0.1526 | |
| GSE97050 | ADAMTS2 | 9509 | A_33_P3409649 | -0.0570 | 0.8918 | |
| SRP007169 | ADAMTS2 | 9509 | RNAseq | 5.0441 | 0.0000 | |
| SRP008496 | ADAMTS2 | 9509 | RNAseq | 4.9088 | 0.0000 | |
| SRP064894 | ADAMTS2 | 9509 | RNAseq | 2.5793 | 0.0000 | |
| SRP133303 | ADAMTS2 | 9509 | RNAseq | 2.6420 | 0.0000 | |
| SRP159526 | ADAMTS2 | 9509 | RNAseq | 2.1171 | 0.0000 | |
| SRP193095 | ADAMTS2 | 9509 | RNAseq | 2.5293 | 0.0000 | |
| SRP219564 | ADAMTS2 | 9509 | RNAseq | 2.6194 | 0.0000 | |
| TCGA | ADAMTS2 | 9509 | RNAseq | 0.5575 | 0.0014 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by ADAMTS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS2 | 9509 | 2 | 12 | 16 | |
| GSE20123 | ADAMTS2 | 9509 | 2 | 12 | 16 | |
| GSE43470 | ADAMTS2 | 9509 | 1 | 11 | 31 | |
| GSE46452 | ADAMTS2 | 9509 | 0 | 27 | 32 | |
| GSE47630 | ADAMTS2 | 9509 | 1 | 20 | 19 | |
| GSE54993 | ADAMTS2 | 9509 | 10 | 2 | 58 | |
| GSE54994 | ADAMTS2 | 9509 | 2 | 17 | 34 | |
| GSE60625 | ADAMTS2 | 9509 | 1 | 0 | 10 | |
| GSE74703 | ADAMTS2 | 9509 | 1 | 7 | 28 | |
| GSE74704 | ADAMTS2 | 9509 | 1 | 6 | 13 | |
| TCGA | ADAMTS2 | 9509 | 10 | 34 | 52 |
Total number of gains: 31; Total number of losses: 148; Total Number of normals: 309.
Somatic mutations of ADAMTS2:
Generating mutation plots.
Highly correlated genes for ADAMTS2:
Showing top 20/598 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS2 | MMP19 | 0.821767 | 3 | 0 | 3 |
| ADAMTS2 | TMEM102 | 0.81534 | 3 | 0 | 3 |
| ADAMTS2 | ADAMTS12 | 0.814333 | 7 | 0 | 6 |
| ADAMTS2 | LAMC2 | 0.798651 | 5 | 0 | 5 |
| ADAMTS2 | F2 | 0.747032 | 3 | 0 | 3 |
| ADAMTS2 | PTGER1 | 0.745455 | 3 | 0 | 3 |
| ADAMTS2 | MMP9 | 0.72905 | 5 | 0 | 5 |
| ADAMTS2 | ZNF77 | 0.72239 | 3 | 0 | 3 |
| ADAMTS2 | RIMS4 | 0.72161 | 3 | 0 | 3 |
| ADAMTS2 | SLC34A1 | 0.72097 | 3 | 0 | 3 |
| ADAMTS2 | GPRIN1 | 0.719907 | 5 | 0 | 5 |
| ADAMTS2 | CCDC106 | 0.717967 | 3 | 0 | 3 |
| ADAMTS2 | COLGALT1 | 0.716732 | 7 | 0 | 7 |
| ADAMTS2 | ITGA11 | 0.716446 | 5 | 0 | 5 |
| ADAMTS2 | CTHRC1 | 0.714719 | 8 | 0 | 6 |
| ADAMTS2 | AGAP2 | 0.706138 | 4 | 0 | 3 |
| ADAMTS2 | FOXD2 | 0.705746 | 4 | 0 | 4 |
| ADAMTS2 | SPATA2L | 0.705177 | 4 | 0 | 3 |
| ADAMTS2 | FBXL8 | 0.703869 | 4 | 0 | 3 |
| ADAMTS2 | C16orf74 | 0.703648 | 5 | 0 | 5 |
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