| Full name: NUMB like endocytic adaptor protein | Alias Symbol: NUMB-R|CTG3a|CAG3A|TNRC23|NUMBR|NUMBLIKE | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 9253 | HGNC ID: HGNC:8061 | Ensembl Gene: ENSG00000105245 | OMIM ID: 604018 |
| Drug and gene relationship at DGIdb | |||
NUMBL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of NUMBL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NUMBL | 9253 | 242195_x_at | 0.3370 | 0.5903 | |
| GSE26886 | NUMBL | 9253 | 242195_x_at | 0.9705 | 0.0001 | |
| GSE45670 | NUMBL | 9253 | 242195_x_at | 0.2425 | 0.0564 | |
| GSE53622 | NUMBL | 9253 | 17403 | -0.2079 | 0.0055 | |
| GSE53624 | NUMBL | 9253 | 17403 | 0.1242 | 0.1182 | |
| GSE63941 | NUMBL | 9253 | 242195_x_at | -0.5145 | 0.0267 | |
| GSE77861 | NUMBL | 9253 | 242195_x_at | 0.7579 | 0.0129 | |
| GSE97050 | NUMBL | 9253 | A_33_P3225091 | -0.2623 | 0.4653 | |
| SRP007169 | NUMBL | 9253 | RNAseq | -0.0278 | 0.9492 | |
| SRP008496 | NUMBL | 9253 | RNAseq | -0.1556 | 0.5685 | |
| SRP064894 | NUMBL | 9253 | RNAseq | 0.2843 | 0.2110 | |
| SRP133303 | NUMBL | 9253 | RNAseq | 0.4504 | 0.0972 | |
| SRP159526 | NUMBL | 9253 | RNAseq | 0.9959 | 0.0004 | |
| SRP193095 | NUMBL | 9253 | RNAseq | 0.7784 | 0.0000 | |
| SRP219564 | NUMBL | 9253 | RNAseq | 0.1650 | 0.6460 | |
| TCGA | NUMBL | 9253 | RNAseq | 0.1658 | 0.0175 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NUMBL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NUMBL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NUMBL | 9253 | 6 | 5 | 19 | |
| GSE20123 | NUMBL | 9253 | 6 | 4 | 20 | |
| GSE43470 | NUMBL | 9253 | 3 | 9 | 31 | |
| GSE46452 | NUMBL | 9253 | 48 | 1 | 10 | |
| GSE47630 | NUMBL | 9253 | 9 | 5 | 26 | |
| GSE54993 | NUMBL | 9253 | 17 | 4 | 49 | |
| GSE54994 | NUMBL | 9253 | 8 | 9 | 36 | |
| GSE60625 | NUMBL | 9253 | 9 | 0 | 2 | |
| GSE74703 | NUMBL | 9253 | 3 | 6 | 27 | |
| GSE74704 | NUMBL | 9253 | 6 | 2 | 12 | |
| TCGA | NUMBL | 9253 | 14 | 16 | 66 |
Total number of gains: 129; Total number of losses: 61; Total Number of normals: 298.
Somatic mutations of NUMBL:
Generating mutation plots.
Highly correlated genes for NUMBL:
Showing top 20/367 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NUMBL | ZDHHC17 | 0.726051 | 3 | 0 | 3 |
| NUMBL | MZT2B | 0.707895 | 6 | 0 | 6 |
| NUMBL | MRPL50 | 0.705592 | 3 | 0 | 3 |
| NUMBL | JMJD6 | 0.703446 | 3 | 0 | 3 |
| NUMBL | CDC42EP3 | 0.69062 | 3 | 0 | 3 |
| NUMBL | RABGEF1 | 0.690601 | 3 | 0 | 3 |
| NUMBL | CWC22 | 0.68654 | 3 | 0 | 3 |
| NUMBL | NFIL3 | 0.686246 | 3 | 0 | 3 |
| NUMBL | CMBL | 0.685937 | 5 | 0 | 5 |
| NUMBL | RIPK2 | 0.681682 | 3 | 0 | 3 |
| NUMBL | RASSF8 | 0.681024 | 3 | 0 | 3 |
| NUMBL | NPHS1 | 0.679484 | 3 | 0 | 3 |
| NUMBL | MET | 0.675371 | 4 | 0 | 3 |
| NUMBL | ZNF721 | 0.673357 | 6 | 0 | 6 |
| NUMBL | ALMS1 | 0.671761 | 4 | 0 | 4 |
| NUMBL | AHI1 | 0.671582 | 4 | 0 | 4 |
| NUMBL | ZNF593 | 0.671551 | 3 | 0 | 3 |
| NUMBL | CLASRP | 0.670276 | 5 | 0 | 5 |
| NUMBL | FUT8-AS1 | 0.669908 | 4 | 0 | 3 |
| NUMBL | BMS1 | 0.669578 | 3 | 0 | 3 |
For details and further investigation, click here
