| Full name: solute carrier family 12 member 7 | Alias Symbol: KCC4|DKFZP434F076 | ||
| Type: protein-coding gene | Cytoband: 5p15.33 | ||
| Entrez ID: 10723 | HGNC ID: HGNC:10915 | Ensembl Gene: ENSG00000113504 | OMIM ID: 604879 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SLC12A7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC12A7 | 10723 | 218066_at | 0.4871 | 0.5152 | |
| GSE20347 | SLC12A7 | 10723 | 218066_at | 1.0085 | 0.0007 | |
| GSE23400 | SLC12A7 | 10723 | 218066_at | 0.3792 | 0.0000 | |
| GSE26886 | SLC12A7 | 10723 | 218066_at | 1.3597 | 0.0000 | |
| GSE29001 | SLC12A7 | 10723 | 218066_at | 0.8161 | 0.0143 | |
| GSE38129 | SLC12A7 | 10723 | 218066_at | 0.7172 | 0.0021 | |
| GSE45670 | SLC12A7 | 10723 | 218066_at | 0.2673 | 0.1984 | |
| GSE53622 | SLC12A7 | 10723 | 81227 | 0.8851 | 0.0000 | |
| GSE53624 | SLC12A7 | 10723 | 75565 | 0.8380 | 0.0000 | |
| GSE63941 | SLC12A7 | 10723 | 218066_at | -0.0767 | 0.9044 | |
| GSE77861 | SLC12A7 | 10723 | 218066_at | 0.4773 | 0.0295 | |
| GSE97050 | SLC12A7 | 10723 | A_33_P3293675 | 0.7356 | 0.1069 | |
| SRP007169 | SLC12A7 | 10723 | RNAseq | 1.7118 | 0.0005 | |
| SRP008496 | SLC12A7 | 10723 | RNAseq | 0.7900 | 0.0632 | |
| SRP064894 | SLC12A7 | 10723 | RNAseq | 0.4717 | 0.0748 | |
| SRP133303 | SLC12A7 | 10723 | RNAseq | 0.6611 | 0.0004 | |
| SRP159526 | SLC12A7 | 10723 | RNAseq | 1.9717 | 0.0001 | |
| SRP193095 | SLC12A7 | 10723 | RNAseq | 1.1933 | 0.0001 | |
| SRP219564 | SLC12A7 | 10723 | RNAseq | 0.9711 | 0.0108 | |
| TCGA | SLC12A7 | 10723 | RNAseq | -0.1296 | 0.1919 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by SLC12A7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC12A7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC12A7 | 10723 | 13 | 1 | 16 | |
| GSE20123 | SLC12A7 | 10723 | 13 | 1 | 16 | |
| GSE43470 | SLC12A7 | 10723 | 17 | 1 | 25 | |
| GSE46452 | SLC12A7 | 10723 | 6 | 22 | 31 | |
| GSE47630 | SLC12A7 | 10723 | 7 | 11 | 22 | |
| GSE54993 | SLC12A7 | 10723 | 5 | 5 | 60 | |
| GSE54994 | SLC12A7 | 10723 | 29 | 1 | 23 | |
| GSE60625 | SLC12A7 | 10723 | 0 | 0 | 11 | |
| GSE74703 | SLC12A7 | 10723 | 14 | 0 | 22 | |
| GSE74704 | SLC12A7 | 10723 | 11 | 0 | 9 | |
| TCGA | SLC12A7 | 10723 | 61 | 3 | 32 |
Total number of gains: 176; Total number of losses: 45; Total Number of normals: 267.
Somatic mutations of SLC12A7:
Generating mutation plots.
Highly correlated genes for SLC12A7:
Showing top 20/693 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC12A7 | WDR81 | 0.781946 | 3 | 0 | 3 |
| SLC12A7 | PAX6 | 0.722555 | 3 | 0 | 3 |
| SLC12A7 | AKNA | 0.717716 | 3 | 0 | 3 |
| SLC12A7 | KCNQ5 | 0.705569 | 3 | 0 | 3 |
| SLC12A7 | TMC8 | 0.702243 | 4 | 0 | 4 |
| SLC12A7 | SIX4 | 0.692912 | 5 | 0 | 5 |
| SLC12A7 | IL4I1 | 0.680625 | 5 | 0 | 5 |
| SLC12A7 | PXYLP1 | 0.678872 | 5 | 0 | 5 |
| SLC12A7 | GBP5 | 0.67516 | 3 | 0 | 3 |
| SLC12A7 | C17orf100 | 0.672035 | 3 | 0 | 3 |
| SLC12A7 | SYT1 | 0.666581 | 4 | 0 | 3 |
| SLC12A7 | ZNF697 | 0.656386 | 3 | 0 | 3 |
| SLC12A7 | CABIN1 | 0.654471 | 3 | 0 | 3 |
| SLC12A7 | ETV5 | 0.648371 | 9 | 0 | 6 |
| SLC12A7 | GRAMD1A | 0.642707 | 6 | 0 | 4 |
| SLC12A7 | ADCY3 | 0.640291 | 7 | 0 | 6 |
| SLC12A7 | RCN1 | 0.639667 | 10 | 0 | 10 |
| SLC12A7 | TNFSF10 | 0.63946 | 3 | 0 | 3 |
| SLC12A7 | CYP2S1 | 0.638989 | 3 | 0 | 3 |
| SLC12A7 | SPRED1 | 0.638655 | 3 | 0 | 3 |
For details and further investigation, click here
