| Full name: plasminogen activator, urokinase receptor | Alias Symbol: URKR|UPAR|CD87 | ||
| Type: protein-coding gene | Cytoband: 19q13 | ||
| Entrez ID: 5329 | HGNC ID: HGNC:9053 | Ensembl Gene: ENSG00000011422 | OMIM ID: 173391 |
| Drug and gene relationship at DGIdb | |||
PLAUR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades | |
| hsa05205 | Proteoglycans in cancer |
Expression of PLAUR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLAUR | 5329 | 210845_s_at | 1.6872 | 0.0479 | |
| GSE20347 | PLAUR | 5329 | 211924_s_at | 1.0795 | 0.0000 | |
| GSE23400 | PLAUR | 5329 | 211924_s_at | 0.4808 | 0.0000 | |
| GSE26886 | PLAUR | 5329 | 210845_s_at | 2.1290 | 0.0000 | |
| GSE29001 | PLAUR | 5329 | 210845_s_at | 1.3259 | 0.0003 | |
| GSE38129 | PLAUR | 5329 | 211924_s_at | 1.3170 | 0.0000 | |
| GSE45670 | PLAUR | 5329 | 211924_s_at | 1.2344 | 0.0209 | |
| GSE53622 | PLAUR | 5329 | 85031 | 1.8970 | 0.0000 | |
| GSE53624 | PLAUR | 5329 | 85031 | 1.8553 | 0.0000 | |
| GSE63941 | PLAUR | 5329 | 211924_s_at | -0.9058 | 0.2284 | |
| GSE77861 | PLAUR | 5329 | 211924_s_at | 0.9932 | 0.0205 | |
| GSE97050 | PLAUR | 5329 | A_23_P16469 | 0.9698 | 0.1377 | |
| SRP007169 | PLAUR | 5329 | RNAseq | 3.9516 | 0.0000 | |
| SRP008496 | PLAUR | 5329 | RNAseq | 3.4732 | 0.0000 | |
| SRP064894 | PLAUR | 5329 | RNAseq | 2.2364 | 0.0000 | |
| SRP133303 | PLAUR | 5329 | RNAseq | 2.2713 | 0.0000 | |
| SRP159526 | PLAUR | 5329 | RNAseq | 1.7559 | 0.0007 | |
| SRP193095 | PLAUR | 5329 | RNAseq | 2.0627 | 0.0000 | |
| SRP219564 | PLAUR | 5329 | RNAseq | 2.4545 | 0.0009 | |
| TCGA | PLAUR | 5329 | RNAseq | 0.4299 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by PLAUR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLAUR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLAUR | 5329 | 6 | 5 | 19 | |
| GSE20123 | PLAUR | 5329 | 5 | 4 | 21 | |
| GSE43470 | PLAUR | 5329 | 4 | 11 | 28 | |
| GSE46452 | PLAUR | 5329 | 45 | 1 | 13 | |
| GSE47630 | PLAUR | 5329 | 8 | 6 | 26 | |
| GSE54993 | PLAUR | 5329 | 17 | 4 | 49 | |
| GSE54994 | PLAUR | 5329 | 6 | 12 | 35 | |
| GSE60625 | PLAUR | 5329 | 9 | 0 | 2 | |
| GSE74703 | PLAUR | 5329 | 4 | 7 | 25 | |
| GSE74704 | PLAUR | 5329 | 4 | 2 | 14 | |
| TCGA | PLAUR | 5329 | 14 | 16 | 66 |
Total number of gains: 122; Total number of losses: 68; Total Number of normals: 298.
Somatic mutations of PLAUR:
Generating mutation plots.
Highly correlated genes for PLAUR:
Showing top 20/1471 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLAUR | MFAP2 | 0.776213 | 11 | 0 | 11 |
| PLAUR | XPR1 | 0.764768 | 7 | 0 | 7 |
| PLAUR | ADAMTSL2 | 0.756309 | 3 | 0 | 3 |
| PLAUR | SERPINE1 | 0.748561 | 13 | 0 | 13 |
| PLAUR | CTHRC1 | 0.747303 | 7 | 0 | 7 |
| PLAUR | ADAMTS15 | 0.74235 | 3 | 0 | 3 |
| PLAUR | PLAU | 0.741665 | 13 | 0 | 12 |
| PLAUR | TMC8 | 0.740889 | 3 | 0 | 3 |
| PLAUR | SH3PXD2B | 0.735456 | 7 | 0 | 7 |
| PLAUR | CXCL8 | 0.733403 | 10 | 0 | 10 |
| PLAUR | FBLIM1 | 0.733239 | 7 | 0 | 7 |
| PLAUR | TTYH3 | 0.731916 | 7 | 0 | 7 |
| PLAUR | TNFRSF12A | 0.730299 | 13 | 0 | 12 |
| PLAUR | LOXL2 | 0.726372 | 12 | 0 | 12 |
| PLAUR | WDR54 | 0.725299 | 7 | 0 | 7 |
| PLAUR | FCGR3A | 0.723785 | 3 | 0 | 3 |
| PLAUR | SLC25A32 | 0.723469 | 11 | 0 | 10 |
| PLAUR | ZNF469 | 0.722177 | 7 | 0 | 7 |
| PLAUR | TREM1 | 0.719721 | 10 | 0 | 10 |
| PLAUR | FNDC3B | 0.717386 | 12 | 0 | 11 |
For details and further investigation, click here
