| Full name: family with sequence similarity 53 member C | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q31.2 | ||
| Entrez ID: 51307 | HGNC ID: HGNC:1336 | Ensembl Gene: ENSG00000120709 | OMIM ID: 609372 |
| Drug and gene relationship at DGIdb | |||
Expression of FAM53C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FAM53C | 51307 | 218023_s_at | 0.2020 | 0.6858 | |
| GSE20347 | FAM53C | 51307 | 218023_s_at | 0.4087 | 0.0029 | |
| GSE23400 | FAM53C | 51307 | 218023_s_at | 0.1181 | 0.0640 | |
| GSE26886 | FAM53C | 51307 | 218023_s_at | -0.0448 | 0.8202 | |
| GSE29001 | FAM53C | 51307 | 218023_s_at | 0.2943 | 0.1715 | |
| GSE38129 | FAM53C | 51307 | 218023_s_at | 0.1600 | 0.2463 | |
| GSE45670 | FAM53C | 51307 | 218023_s_at | 0.1397 | 0.3096 | |
| GSE53622 | FAM53C | 51307 | 154515 | -0.1885 | 0.0034 | |
| GSE53624 | FAM53C | 51307 | 154515 | 0.0966 | 0.0448 | |
| GSE63941 | FAM53C | 51307 | 218023_s_at | -0.1913 | 0.6403 | |
| GSE77861 | FAM53C | 51307 | 218023_s_at | 0.1045 | 0.4484 | |
| GSE97050 | FAM53C | 51307 | A_23_P167789 | -0.4415 | 0.3612 | |
| SRP007169 | FAM53C | 51307 | RNAseq | -0.0135 | 0.9727 | |
| SRP008496 | FAM53C | 51307 | RNAseq | -0.2354 | 0.3961 | |
| SRP064894 | FAM53C | 51307 | RNAseq | -0.0887 | 0.4304 | |
| SRP133303 | FAM53C | 51307 | RNAseq | 0.5573 | 0.0615 | |
| SRP159526 | FAM53C | 51307 | RNAseq | 0.0500 | 0.8023 | |
| SRP193095 | FAM53C | 51307 | RNAseq | 0.1215 | 0.2788 | |
| SRP219564 | FAM53C | 51307 | RNAseq | -0.2013 | 0.5788 | |
| TCGA | FAM53C | 51307 | RNAseq | -0.1309 | 0.0073 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FAM53C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FAM53C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FAM53C | 51307 | 3 | 10 | 17 | |
| GSE20123 | FAM53C | 51307 | 4 | 10 | 16 | |
| GSE43470 | FAM53C | 51307 | 4 | 5 | 34 | |
| GSE46452 | FAM53C | 51307 | 0 | 27 | 32 | |
| GSE47630 | FAM53C | 51307 | 0 | 21 | 19 | |
| GSE54993 | FAM53C | 51307 | 9 | 1 | 60 | |
| GSE54994 | FAM53C | 51307 | 3 | 13 | 37 | |
| GSE60625 | FAM53C | 51307 | 0 | 0 | 11 | |
| GSE74703 | FAM53C | 51307 | 3 | 4 | 29 | |
| GSE74704 | FAM53C | 51307 | 3 | 4 | 13 | |
| TCGA | FAM53C | 51307 | 3 | 37 | 56 |
Total number of gains: 32; Total number of losses: 132; Total Number of normals: 324.
Somatic mutations of FAM53C:
Generating mutation plots.
Highly correlated genes for FAM53C:
Showing top 20/261 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FAM53C | SNX27 | 0.7451 | 3 | 0 | 3 |
| FAM53C | NUB1 | 0.713415 | 3 | 0 | 3 |
| FAM53C | REEP2 | 0.710755 | 3 | 0 | 3 |
| FAM53C | MLLT1 | 0.685474 | 3 | 0 | 3 |
| FAM53C | DIRAS1 | 0.685369 | 3 | 0 | 3 |
| FAM53C | PLXNB3 | 0.684993 | 4 | 0 | 3 |
| FAM53C | ANKRD40 | 0.68368 | 3 | 0 | 3 |
| FAM53C | NCOA6 | 0.678875 | 3 | 0 | 3 |
| FAM53C | THAP8 | 0.672333 | 3 | 0 | 3 |
| FAM53C | SEMA3C | 0.67168 | 4 | 0 | 4 |
| FAM53C | HES4 | 0.671541 | 3 | 0 | 3 |
| FAM53C | PDHX | 0.671329 | 4 | 0 | 3 |
| FAM53C | TAF1C | 0.668053 | 3 | 0 | 3 |
| FAM53C | C1orf198 | 0.66363 | 3 | 0 | 3 |
| FAM53C | BEGAIN | 0.663416 | 3 | 0 | 3 |
| FAM53C | MRPS14 | 0.660245 | 3 | 0 | 3 |
| FAM53C | MYLIP | 0.650053 | 5 | 0 | 4 |
| FAM53C | DYNLL2 | 0.649879 | 3 | 0 | 3 |
| FAM53C | OSGEP | 0.649181 | 3 | 0 | 3 |
| FAM53C | UGGT2 | 0.645863 | 4 | 0 | 3 |
For details and further investigation, click here
