| Full name: sphingosine-1-phosphate receptor 3 | Alias Symbol: EDG-3 | ||
| Type: protein-coding gene | Cytoband: 9q22.1 | ||
| Entrez ID: 1903 | HGNC ID: HGNC:3167 | Ensembl Gene: ENSG00000213694 | OMIM ID: 601965 |
| Drug and gene relationship at DGIdb | |||
S1PR3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04071 | Sphingolipid signaling pathway |
Expression of S1PR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | S1PR3 | 1903 | 228176_at | -1.2484 | 0.3521 | |
| GSE26886 | S1PR3 | 1903 | 228176_at | 1.5088 | 0.0021 | |
| GSE45670 | S1PR3 | 1903 | 228176_at | -1.6070 | 0.0027 | |
| GSE53622 | S1PR3 | 1903 | 18998 | -0.6484 | 0.0013 | |
| GSE53624 | S1PR3 | 1903 | 18998 | -0.1249 | 0.5115 | |
| GSE63941 | S1PR3 | 1903 | 228176_at | -5.2560 | 0.0011 | |
| GSE77861 | S1PR3 | 1903 | 228176_at | 0.6957 | 0.1269 | |
| GSE97050 | S1PR3 | 1903 | A_33_P3281283 | -0.9874 | 0.3235 | |
| SRP007169 | S1PR3 | 1903 | RNAseq | 1.6933 | 0.0089 | |
| SRP008496 | S1PR3 | 1903 | RNAseq | 2.2485 | 0.0000 | |
| SRP064894 | S1PR3 | 1903 | RNAseq | 0.2762 | 0.4291 | |
| SRP133303 | S1PR3 | 1903 | RNAseq | 0.4499 | 0.3981 | |
| SRP159526 | S1PR3 | 1903 | RNAseq | -0.0428 | 0.9412 | |
| SRP193095 | S1PR3 | 1903 | RNAseq | 1.1165 | 0.0000 | |
| SRP219564 | S1PR3 | 1903 | RNAseq | -0.1797 | 0.8712 | |
| TCGA | S1PR3 | 1903 | RNAseq | -0.3854 | 0.0059 |
Upregulated datasets: 4; Downregulated datasets: 2.
Survival by S1PR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of S1PR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | S1PR3 | 1903 | 5 | 10 | 15 | |
| GSE20123 | S1PR3 | 1903 | 5 | 10 | 15 | |
| GSE43470 | S1PR3 | 1903 | 6 | 3 | 34 | |
| GSE46452 | S1PR3 | 1903 | 6 | 14 | 39 | |
| GSE47630 | S1PR3 | 1903 | 1 | 18 | 21 | |
| GSE54993 | S1PR3 | 1903 | 4 | 2 | 64 | |
| GSE54994 | S1PR3 | 1903 | 6 | 11 | 36 | |
| GSE60625 | S1PR3 | 1903 | 0 | 0 | 11 | |
| GSE74703 | S1PR3 | 1903 | 5 | 3 | 28 | |
| GSE74704 | S1PR3 | 1903 | 3 | 7 | 10 | |
| TCGA | S1PR3 | 1903 | 21 | 24 | 51 |
Total number of gains: 62; Total number of losses: 102; Total Number of normals: 324.
Somatic mutations of S1PR3:
Generating mutation plots.
Highly correlated genes for S1PR3:
Showing top 20/1024 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| S1PR3 | ALPK3 | 0.814106 | 3 | 0 | 3 |
| S1PR3 | TCEAL6 | 0.812695 | 3 | 0 | 3 |
| S1PR3 | CYP4V2 | 0.803474 | 3 | 0 | 3 |
| S1PR3 | C11orf96 | 0.786501 | 5 | 0 | 5 |
| S1PR3 | ACO1 | 0.78327 | 4 | 0 | 4 |
| S1PR3 | UBXN10 | 0.778688 | 3 | 0 | 3 |
| S1PR3 | HSPB6 | 0.774758 | 3 | 0 | 3 |
| S1PR3 | ANK2 | 0.774104 | 5 | 0 | 5 |
| S1PR3 | CEP290 | 0.773025 | 3 | 0 | 3 |
| S1PR3 | ZNF347 | 0.770042 | 3 | 0 | 3 |
| S1PR3 | TCEAL5 | 0.766977 | 3 | 0 | 3 |
| S1PR3 | MYADM | 0.757468 | 6 | 0 | 5 |
| S1PR3 | ZFAND2A | 0.755054 | 3 | 0 | 3 |
| S1PR3 | JAM3 | 0.753069 | 9 | 0 | 8 |
| S1PR3 | DCHS1 | 0.752957 | 6 | 0 | 6 |
| S1PR3 | CNTLN | 0.750287 | 3 | 0 | 3 |
| S1PR3 | SH3RF3 | 0.749567 | 4 | 0 | 4 |
| S1PR3 | PDE5A | 0.749394 | 6 | 0 | 6 |
| S1PR3 | ZCCHC24 | 0.748429 | 8 | 0 | 7 |
| S1PR3 | DCLK2 | 0.748259 | 3 | 0 | 3 |
For details and further investigation, click here
