| Full name: centrosomal protein 290 | Alias Symbol: KIAA0373|FLJ13615|3H11Ag|rd16|NPHP6|JBTS5|SLSN6|LCA10|MKS4|BBS14|CT87|POC3 | ||
| Type: protein-coding gene | Cytoband: 12q21.32 | ||
| Entrez ID: 80184 | HGNC ID: HGNC:29021 | Ensembl Gene: ENSG00000198707 | OMIM ID: 610142 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CEP290:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CEP290 | 80184 | 205250_s_at | 0.3697 | 0.3436 | |
| GSE20347 | CEP290 | 80184 | 205250_s_at | 0.7082 | 0.0000 | |
| GSE23400 | CEP290 | 80184 | 205250_s_at | 0.2176 | 0.0000 | |
| GSE26886 | CEP290 | 80184 | 205250_s_at | 2.4986 | 0.0000 | |
| GSE29001 | CEP290 | 80184 | 205250_s_at | 0.8083 | 0.0303 | |
| GSE38129 | CEP290 | 80184 | 205250_s_at | 0.5082 | 0.0003 | |
| GSE45670 | CEP290 | 80184 | 205250_s_at | 0.0639 | 0.7849 | |
| GSE53622 | CEP290 | 80184 | 84589 | 0.8018 | 0.0000 | |
| GSE53624 | CEP290 | 80184 | 84589 | 0.8459 | 0.0000 | |
| GSE63941 | CEP290 | 80184 | 205250_s_at | -0.2057 | 0.7517 | |
| GSE77861 | CEP290 | 80184 | 205250_s_at | 0.5624 | 0.0409 | |
| GSE97050 | CEP290 | 80184 | A_23_P36865 | -0.2125 | 0.3980 | |
| SRP007169 | CEP290 | 80184 | RNAseq | 2.5998 | 0.0000 | |
| SRP008496 | CEP290 | 80184 | RNAseq | 2.9865 | 0.0000 | |
| SRP064894 | CEP290 | 80184 | RNAseq | 0.8137 | 0.0004 | |
| SRP133303 | CEP290 | 80184 | RNAseq | 0.9086 | 0.0000 | |
| SRP159526 | CEP290 | 80184 | RNAseq | 1.1473 | 0.0035 | |
| SRP193095 | CEP290 | 80184 | RNAseq | 1.0726 | 0.0000 | |
| SRP219564 | CEP290 | 80184 | RNAseq | 0.6850 | 0.0130 | |
| TCGA | CEP290 | 80184 | RNAseq | -0.0768 | 0.4703 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by CEP290 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CEP290:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CEP290 | 80184 | 3 | 3 | 24 | |
| GSE20123 | CEP290 | 80184 | 3 | 3 | 24 | |
| GSE43470 | CEP290 | 80184 | 3 | 1 | 39 | |
| GSE46452 | CEP290 | 80184 | 9 | 1 | 49 | |
| GSE47630 | CEP290 | 80184 | 10 | 1 | 29 | |
| GSE54993 | CEP290 | 80184 | 0 | 6 | 64 | |
| GSE54994 | CEP290 | 80184 | 7 | 1 | 45 | |
| GSE60625 | CEP290 | 80184 | 0 | 0 | 11 | |
| GSE74703 | CEP290 | 80184 | 3 | 1 | 32 | |
| GSE74704 | CEP290 | 80184 | 1 | 3 | 16 | |
| TCGA | CEP290 | 80184 | 19 | 10 | 67 |
Total number of gains: 58; Total number of losses: 30; Total Number of normals: 400.
Somatic mutations of CEP290:
Generating mutation plots.
Highly correlated genes for CEP290:
Showing top 20/1822 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CEP290 | TMTC1 | 0.838852 | 3 | 0 | 3 |
| CEP290 | RPS19BP1 | 0.833311 | 3 | 0 | 3 |
| CEP290 | SGTB | 0.826551 | 3 | 0 | 3 |
| CEP290 | ESCO1 | 0.801163 | 3 | 0 | 3 |
| CEP290 | C20orf194 | 0.788385 | 3 | 0 | 3 |
| CEP290 | RUNDC1 | 0.785194 | 3 | 0 | 3 |
| CEP290 | ALKBH6 | 0.783351 | 3 | 0 | 3 |
| CEP290 | INPP5B | 0.781802 | 3 | 0 | 3 |
| CEP290 | ZNF627 | 0.78066 | 3 | 0 | 3 |
| CEP290 | S1PR3 | 0.773025 | 3 | 0 | 3 |
| CEP290 | KRTCAP2 | 0.772132 | 3 | 0 | 3 |
| CEP290 | RSBN1L | 0.761364 | 3 | 0 | 3 |
| CEP290 | LSM10 | 0.760051 | 4 | 0 | 4 |
| CEP290 | ZBED1 | 0.75293 | 3 | 0 | 3 |
| CEP290 | COA5 | 0.751895 | 3 | 0 | 3 |
| CEP290 | TIGD1 | 0.744373 | 4 | 0 | 3 |
| CEP290 | C6orf141 | 0.742984 | 3 | 0 | 3 |
| CEP290 | FADS1 | 0.734623 | 3 | 0 | 3 |
| CEP290 | UBP1 | 0.728393 | 3 | 0 | 3 |
| CEP290 | HMCN1 | 0.721856 | 3 | 0 | 3 |
For details and further investigation, click here
