| Full name: phosphodiesterase 5A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q26 | ||
| Entrez ID: 8654 | HGNC ID: HGNC:8784 | Ensembl Gene: ENSG00000138735 | OMIM ID: 603310 |
| Drug and gene relationship at DGIdb | |||
Expression of PDE5A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDE5A | 8654 | 227088_at | -2.2924 | 0.0900 | |
| GSE20347 | PDE5A | 8654 | 206757_at | -0.1022 | 0.2994 | |
| GSE23400 | PDE5A | 8654 | 206757_at | -0.1734 | 0.0662 | |
| GSE26886 | PDE5A | 8654 | 1562228_s_at | -0.1571 | 0.4182 | |
| GSE29001 | PDE5A | 8654 | 206757_at | -0.0877 | 0.6110 | |
| GSE38129 | PDE5A | 8654 | 206757_at | -0.6066 | 0.0281 | |
| GSE45670 | PDE5A | 8654 | 227088_at | -3.5321 | 0.0000 | |
| GSE53622 | PDE5A | 8654 | 63874 | -1.3916 | 0.0000 | |
| GSE53624 | PDE5A | 8654 | 63874 | -1.5567 | 0.0000 | |
| GSE63941 | PDE5A | 8654 | 227088_at | -5.7213 | 0.0000 | |
| GSE77861 | PDE5A | 8654 | 1562228_s_at | -0.1717 | 0.2319 | |
| GSE97050 | PDE5A | 8654 | A_33_P3378514 | -1.1549 | 0.0971 | |
| SRP007169 | PDE5A | 8654 | RNAseq | 2.2916 | 0.0000 | |
| SRP008496 | PDE5A | 8654 | RNAseq | 3.1918 | 0.0000 | |
| SRP064894 | PDE5A | 8654 | RNAseq | -0.4962 | 0.2190 | |
| SRP133303 | PDE5A | 8654 | RNAseq | -1.6201 | 0.0000 | |
| SRP159526 | PDE5A | 8654 | RNAseq | -0.4279 | 0.4595 | |
| SRP193095 | PDE5A | 8654 | RNAseq | -0.2174 | 0.3737 | |
| SRP219564 | PDE5A | 8654 | RNAseq | -0.0614 | 0.9564 | |
| TCGA | PDE5A | 8654 | RNAseq | -0.5240 | 0.0011 |
Upregulated datasets: 2; Downregulated datasets: 5.
Survival by PDE5A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDE5A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDE5A | 8654 | 1 | 13 | 16 | |
| GSE20123 | PDE5A | 8654 | 1 | 13 | 16 | |
| GSE43470 | PDE5A | 8654 | 0 | 13 | 30 | |
| GSE46452 | PDE5A | 8654 | 1 | 36 | 22 | |
| GSE47630 | PDE5A | 8654 | 0 | 22 | 18 | |
| GSE54993 | PDE5A | 8654 | 9 | 0 | 61 | |
| GSE54994 | PDE5A | 8654 | 1 | 10 | 42 | |
| GSE60625 | PDE5A | 8654 | 0 | 1 | 10 | |
| GSE74703 | PDE5A | 8654 | 0 | 11 | 25 | |
| GSE74704 | PDE5A | 8654 | 0 | 7 | 13 | |
| TCGA | PDE5A | 8654 | 9 | 34 | 53 |
Total number of gains: 22; Total number of losses: 160; Total Number of normals: 306.
Somatic mutations of PDE5A:
Generating mutation plots.
Highly correlated genes for PDE5A:
Showing top 20/1302 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDE5A | MRVI1 | 0.88304 | 7 | 0 | 7 |
| PDE5A | RBPMS2 | 0.878584 | 6 | 0 | 6 |
| PDE5A | SORCS1 | 0.878554 | 4 | 0 | 4 |
| PDE5A | UBXN10 | 0.874279 | 3 | 0 | 3 |
| PDE5A | FENDRR | 0.873007 | 5 | 0 | 5 |
| PDE5A | ANGPTL1 | 0.852843 | 6 | 0 | 6 |
| PDE5A | LINC01279 | 0.852832 | 3 | 0 | 3 |
| PDE5A | SYNPO2 | 0.847675 | 7 | 0 | 7 |
| PDE5A | XKR4 | 0.844373 | 5 | 0 | 5 |
| PDE5A | CLEC3B | 0.843151 | 3 | 0 | 3 |
| PDE5A | MIR100HG | 0.842313 | 5 | 0 | 5 |
| PDE5A | CYP21A2 | 0.841696 | 3 | 0 | 3 |
| PDE5A | C3orf70 | 0.838594 | 6 | 0 | 6 |
| PDE5A | MYOCD | 0.837711 | 7 | 0 | 6 |
| PDE5A | GFRA1 | 0.831635 | 7 | 0 | 7 |
| PDE5A | LRRN4CL | 0.830385 | 6 | 0 | 6 |
| PDE5A | ADAMTS9-AS2 | 0.823191 | 6 | 0 | 6 |
| PDE5A | MSRB3 | 0.821606 | 8 | 0 | 8 |
| PDE5A | KCNT2 | 0.820332 | 6 | 0 | 6 |
| PDE5A | NEGR1 | 0.819798 | 7 | 0 | 7 |
For details and further investigation, click here
