| Full name: ankyrin 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q25-q26 | ||
| Entrez ID: 287 | HGNC ID: HGNC:493 | Ensembl Gene: ENSG00000145362 | OMIM ID: 106410 |
| Drug and gene relationship at DGIdb | |||
ANK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of ANK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANK2 | 287 | 202920_at | -2.1177 | 0.1811 | |
| GSE20347 | ANK2 | 287 | 202920_at | -0.4211 | 0.1700 | |
| GSE23400 | ANK2 | 287 | 202921_s_at | -0.2735 | 0.0006 | |
| GSE26886 | ANK2 | 287 | 216195_at | 0.0357 | 0.7039 | |
| GSE29001 | ANK2 | 287 | 202920_at | -0.1661 | 0.4721 | |
| GSE38129 | ANK2 | 287 | 202920_at | -1.2491 | 0.0351 | |
| GSE45670 | ANK2 | 287 | 202920_at | -3.6910 | 0.0000 | |
| GSE53622 | ANK2 | 287 | 97826 | -1.6167 | 0.0000 | |
| GSE53624 | ANK2 | 287 | 97826 | -1.0973 | 0.0000 | |
| GSE63941 | ANK2 | 287 | 202920_at | -4.9134 | 0.0000 | |
| GSE77861 | ANK2 | 287 | 202921_s_at | -0.1340 | 0.2054 | |
| GSE97050 | ANK2 | 287 | A_33_P3287967 | -1.1700 | 0.1398 | |
| SRP007169 | ANK2 | 287 | RNAseq | 2.9737 | 0.0001 | |
| SRP064894 | ANK2 | 287 | RNAseq | 0.1211 | 0.8189 | |
| SRP133303 | ANK2 | 287 | RNAseq | -1.3265 | 0.0022 | |
| SRP159526 | ANK2 | 287 | RNAseq | -1.0514 | 0.0017 | |
| SRP193095 | ANK2 | 287 | RNAseq | 0.2480 | 0.5608 | |
| SRP219564 | ANK2 | 287 | RNAseq | -0.5659 | 0.6286 | |
| TCGA | ANK2 | 287 | RNAseq | -1.1427 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 8.
Survival by ANK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANK2 | 287 | 1 | 13 | 16 | |
| GSE20123 | ANK2 | 287 | 1 | 13 | 16 | |
| GSE43470 | ANK2 | 287 | 0 | 14 | 29 | |
| GSE46452 | ANK2 | 287 | 1 | 36 | 22 | |
| GSE47630 | ANK2 | 287 | 0 | 22 | 18 | |
| GSE54993 | ANK2 | 287 | 9 | 0 | 61 | |
| GSE54994 | ANK2 | 287 | 1 | 11 | 41 | |
| GSE60625 | ANK2 | 287 | 0 | 3 | 8 | |
| GSE74703 | ANK2 | 287 | 0 | 12 | 24 | |
| GSE74704 | ANK2 | 287 | 0 | 7 | 13 | |
| TCGA | ANK2 | 287 | 8 | 35 | 53 |
Total number of gains: 21; Total number of losses: 166; Total Number of normals: 301.
Somatic mutations of ANK2:
Generating mutation plots.
Highly correlated genes for ANK2:
Showing top 20/1136 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANK2 | MYOCD | 0.853487 | 6 | 0 | 6 |
| ANK2 | XKR4 | 0.831932 | 5 | 0 | 5 |
| ANK2 | SYNPO2 | 0.830968 | 6 | 0 | 6 |
| ANK2 | CYP21A2 | 0.828758 | 3 | 0 | 3 |
| ANK2 | FILIP1 | 0.820934 | 5 | 0 | 5 |
| ANK2 | BHMT2 | 0.820337 | 10 | 0 | 10 |
| ANK2 | MAGI2-AS3 | 0.820063 | 5 | 0 | 5 |
| ANK2 | CHRDL1 | 0.815874 | 9 | 0 | 8 |
| ANK2 | CLEC3B | 0.81447 | 3 | 0 | 3 |
| ANK2 | GFRA1 | 0.812969 | 6 | 0 | 6 |
| ANK2 | CNRIP1 | 0.804894 | 5 | 0 | 5 |
| ANK2 | INMT | 0.801566 | 6 | 0 | 6 |
| ANK2 | NEGR1 | 0.795903 | 7 | 0 | 7 |
| ANK2 | SCN7A | 0.792895 | 8 | 0 | 8 |
| ANK2 | C11orf96 | 0.791932 | 4 | 0 | 4 |
| ANK2 | ABCA8 | 0.791756 | 10 | 0 | 9 |
| ANK2 | JAM3 | 0.7914 | 10 | 0 | 9 |
| ANK2 | LRRN4CL | 0.790564 | 6 | 0 | 5 |
| ANK2 | FAM13C | 0.788306 | 5 | 0 | 5 |
| ANK2 | CLIP3 | 0.787002 | 9 | 0 | 9 |
For details and further investigation, click here
