| Full name: aconitase 1 | Alias Symbol: IRP1|IREBP | ||
| Type: protein-coding gene | Cytoband: 9p21.1 | ||
| Entrez ID: 48 | HGNC ID: HGNC:117 | Ensembl Gene: ENSG00000122729 | OMIM ID: 100880 |
| Drug and gene relationship at DGIdb | |||
Expression of ACO1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACO1 | 48 | 207071_s_at | -0.4991 | 0.3333 | |
| GSE20347 | ACO1 | 48 | 207071_s_at | -0.3526 | 0.0120 | |
| GSE23400 | ACO1 | 48 | 207071_s_at | -0.1143 | 0.1020 | |
| GSE26886 | ACO1 | 48 | 207071_s_at | -0.6016 | 0.0324 | |
| GSE29001 | ACO1 | 48 | 207071_s_at | -0.3822 | 0.1102 | |
| GSE38129 | ACO1 | 48 | 207071_s_at | -0.5732 | 0.0028 | |
| GSE45670 | ACO1 | 48 | 207071_s_at | -0.3397 | 0.0482 | |
| GSE53622 | ACO1 | 48 | 9215 | -0.4780 | 0.0001 | |
| GSE53624 | ACO1 | 48 | 79208 | -0.1151 | 0.0444 | |
| GSE63941 | ACO1 | 48 | 207071_s_at | -2.8171 | 0.0006 | |
| GSE77861 | ACO1 | 48 | 207071_s_at | 0.0393 | 0.9419 | |
| GSE97050 | ACO1 | 48 | A_23_P9415 | -0.4923 | 0.1262 | |
| SRP007169 | ACO1 | 48 | RNAseq | 0.2208 | 0.5709 | |
| SRP008496 | ACO1 | 48 | RNAseq | 0.3564 | 0.0820 | |
| SRP064894 | ACO1 | 48 | RNAseq | 0.2930 | 0.0995 | |
| SRP133303 | ACO1 | 48 | RNAseq | 0.0035 | 0.9883 | |
| SRP159526 | ACO1 | 48 | RNAseq | -0.3393 | 0.2709 | |
| SRP193095 | ACO1 | 48 | RNAseq | -0.5302 | 0.0180 | |
| SRP219564 | ACO1 | 48 | RNAseq | -0.7052 | 0.3375 | |
| TCGA | ACO1 | 48 | RNAseq | -0.4535 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ACO1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACO1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACO1 | 48 | 2 | 15 | 13 | |
| GSE20123 | ACO1 | 48 | 2 | 15 | 13 | |
| GSE43470 | ACO1 | 48 | 3 | 9 | 31 | |
| GSE46452 | ACO1 | 48 | 6 | 17 | 36 | |
| GSE47630 | ACO1 | 48 | 1 | 21 | 18 | |
| GSE54993 | ACO1 | 48 | 6 | 0 | 64 | |
| GSE54994 | ACO1 | 48 | 7 | 11 | 35 | |
| GSE60625 | ACO1 | 48 | 0 | 0 | 11 | |
| GSE74703 | ACO1 | 48 | 2 | 7 | 27 | |
| GSE74704 | ACO1 | 48 | 0 | 11 | 9 | |
| TCGA | ACO1 | 48 | 17 | 44 | 35 |
Total number of gains: 46; Total number of losses: 150; Total Number of normals: 292.
Somatic mutations of ACO1:
Generating mutation plots.
Highly correlated genes for ACO1:
Showing top 20/1001 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACO1 | FGFR1 | 0.814309 | 4 | 0 | 4 |
| ACO1 | FKBP7 | 0.793263 | 3 | 0 | 3 |
| ACO1 | S1PR3 | 0.78327 | 4 | 0 | 4 |
| ACO1 | MIER1 | 0.774353 | 3 | 0 | 3 |
| ACO1 | ZNF583 | 0.772576 | 3 | 0 | 3 |
| ACO1 | UBXN10 | 0.765092 | 3 | 0 | 3 |
| ACO1 | TBX5 | 0.758952 | 4 | 0 | 3 |
| ACO1 | ZNF521 | 0.757388 | 3 | 0 | 3 |
| ACO1 | ZNF407 | 0.754615 | 3 | 0 | 3 |
| ACO1 | PRICKLE2 | 0.753778 | 5 | 0 | 4 |
| ACO1 | TNFRSF19 | 0.753774 | 3 | 0 | 3 |
| ACO1 | PRKCA | 0.753628 | 6 | 0 | 6 |
| ACO1 | FRY | 0.748922 | 5 | 0 | 5 |
| ACO1 | C20orf194 | 0.748851 | 3 | 0 | 3 |
| ACO1 | FIBIN | 0.748724 | 4 | 0 | 3 |
| ACO1 | VAT1L | 0.743119 | 3 | 0 | 3 |
| ACO1 | CNRIP1 | 0.74172 | 5 | 0 | 4 |
| ACO1 | FOXN3 | 0.736747 | 6 | 0 | 6 |
| ACO1 | SLC16A2 | 0.735929 | 3 | 0 | 3 |
| ACO1 | RGMB | 0.732693 | 4 | 0 | 4 |
For details and further investigation, click here
