| Full name: alpha kinase 3 | Alias Symbol: MAK|KIAA1330|Midori | ||
| Type: protein-coding gene | Cytoband: 15q25.3 | ||
| Entrez ID: 57538 | HGNC ID: HGNC:17574 | Ensembl Gene: ENSG00000136383 | OMIM ID: 617608 |
| Drug and gene relationship at DGIdb | |||
Expression of ALPK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALPK3 | 57538 | 214846_s_at | -0.1460 | 0.7821 | |
| GSE20347 | ALPK3 | 57538 | 214846_s_at | -0.0193 | 0.8419 | |
| GSE23400 | ALPK3 | 57538 | 214846_s_at | -0.1562 | 0.0001 | |
| GSE26886 | ALPK3 | 57538 | 214846_s_at | 0.1305 | 0.3053 | |
| GSE29001 | ALPK3 | 57538 | 214846_s_at | -0.0302 | 0.8499 | |
| GSE38129 | ALPK3 | 57538 | 214846_s_at | -0.3015 | 0.0060 | |
| GSE45670 | ALPK3 | 57538 | 214846_s_at | -0.0981 | 0.3611 | |
| GSE53622 | ALPK3 | 57538 | 47212 | -0.3657 | 0.0103 | |
| GSE53624 | ALPK3 | 57538 | 47212 | 0.0653 | 0.5910 | |
| GSE63941 | ALPK3 | 57538 | 214846_s_at | 0.2137 | 0.5322 | |
| GSE77861 | ALPK3 | 57538 | 214846_s_at | 0.0774 | 0.4981 | |
| GSE97050 | ALPK3 | 57538 | A_33_P3210099 | -0.7031 | 0.1887 | |
| SRP007169 | ALPK3 | 57538 | RNAseq | -0.8107 | 0.1310 | |
| SRP064894 | ALPK3 | 57538 | RNAseq | -0.0924 | 0.7592 | |
| SRP133303 | ALPK3 | 57538 | RNAseq | -0.0309 | 0.9266 | |
| SRP159526 | ALPK3 | 57538 | RNAseq | -0.8610 | 0.0916 | |
| SRP193095 | ALPK3 | 57538 | RNAseq | 0.0852 | 0.7559 | |
| SRP219564 | ALPK3 | 57538 | RNAseq | -0.2265 | 0.7470 | |
| TCGA | ALPK3 | 57538 | RNAseq | -0.7500 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ALPK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALPK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALPK3 | 57538 | 8 | 0 | 22 | |
| GSE20123 | ALPK3 | 57538 | 8 | 0 | 22 | |
| GSE43470 | ALPK3 | 57538 | 4 | 4 | 35 | |
| GSE46452 | ALPK3 | 57538 | 3 | 7 | 49 | |
| GSE47630 | ALPK3 | 57538 | 8 | 10 | 22 | |
| GSE54993 | ALPK3 | 57538 | 5 | 6 | 59 | |
| GSE54994 | ALPK3 | 57538 | 6 | 6 | 41 | |
| GSE60625 | ALPK3 | 57538 | 4 | 0 | 7 | |
| GSE74703 | ALPK3 | 57538 | 4 | 2 | 30 | |
| GSE74704 | ALPK3 | 57538 | 4 | 0 | 16 | |
| TCGA | ALPK3 | 57538 | 16 | 13 | 67 |
Total number of gains: 70; Total number of losses: 48; Total Number of normals: 370.
Somatic mutations of ALPK3:
Generating mutation plots.
Highly correlated genes for ALPK3:
Showing top 20/716 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALPK3 | S1PR3 | 0.814106 | 3 | 0 | 3 |
| ALPK3 | ANO6 | 0.799234 | 3 | 0 | 3 |
| ALPK3 | LRCH2 | 0.790352 | 4 | 0 | 4 |
| ALPK3 | IQUB | 0.776486 | 3 | 0 | 3 |
| ALPK3 | EID1 | 0.75645 | 4 | 0 | 4 |
| ALPK3 | ENO2 | 0.750926 | 3 | 0 | 3 |
| ALPK3 | RASSF3 | 0.750556 | 3 | 0 | 3 |
| ALPK3 | LSM11 | 0.750536 | 4 | 0 | 4 |
| ALPK3 | TRIM45 | 0.746507 | 3 | 0 | 3 |
| ALPK3 | CNRIP1 | 0.74325 | 4 | 0 | 4 |
| ALPK3 | ZNF382 | 0.729742 | 3 | 0 | 3 |
| ALPK3 | CYP2U1 | 0.726029 | 4 | 0 | 4 |
| ALPK3 | ANKRD40 | 0.725299 | 4 | 0 | 3 |
| ALPK3 | NPTX1 | 0.721293 | 4 | 0 | 4 |
| ALPK3 | LENG8 | 0.721249 | 3 | 0 | 3 |
| ALPK3 | UBXN10 | 0.720789 | 4 | 0 | 4 |
| ALPK3 | JAZF1 | 0.7207 | 3 | 0 | 3 |
| ALPK3 | CORO6 | 0.71956 | 3 | 0 | 3 |
| ALPK3 | DPYSL3 | 0.7179 | 4 | 0 | 4 |
| ALPK3 | UBR1 | 0.714423 | 3 | 0 | 3 |
For details and further investigation, click here
