| Full name: doublecortin like kinase 2 | Alias Symbol: MGC45428|DCDC3|DCDC3B|DCK2 | ||
| Type: protein-coding gene | Cytoband: 4q31.23-q31.3 | ||
| Entrez ID: 166614 | HGNC ID: HGNC:19002 | Ensembl Gene: ENSG00000170390 | OMIM ID: 613166 |
| Drug and gene relationship at DGIdb | |||
Expression of DCLK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DCLK2 | 166614 | 227666_at | -0.2690 | 0.3829 | |
| GSE20347 | DCLK2 | 166614 | 216725_at | -0.0386 | 0.6164 | |
| GSE23400 | DCLK2 | 166614 | 216724_at | -0.1378 | 0.0000 | |
| GSE26886 | DCLK2 | 166614 | 216725_at | 0.0172 | 0.9126 | |
| GSE29001 | DCLK2 | 166614 | 216724_at | -0.0999 | 0.5756 | |
| GSE38129 | DCLK2 | 166614 | 216725_at | -0.1007 | 0.1802 | |
| GSE45670 | DCLK2 | 166614 | 216725_at | 0.0411 | 0.6592 | |
| GSE53622 | DCLK2 | 166614 | 34603 | -0.5269 | 0.0025 | |
| GSE53624 | DCLK2 | 166614 | 114688 | -0.0082 | 0.9555 | |
| GSE63941 | DCLK2 | 166614 | 216725_at | 0.1774 | 0.2225 | |
| GSE77861 | DCLK2 | 166614 | 216725_at | -0.1302 | 0.2813 | |
| GSE97050 | DCLK2 | 166614 | A_33_P3237734 | -0.9868 | 0.1578 | |
| SRP007169 | DCLK2 | 166614 | RNAseq | 1.2853 | 0.1619 | |
| SRP064894 | DCLK2 | 166614 | RNAseq | -0.1128 | 0.6959 | |
| SRP133303 | DCLK2 | 166614 | RNAseq | 0.1865 | 0.6093 | |
| SRP159526 | DCLK2 | 166614 | RNAseq | 0.0375 | 0.9490 | |
| SRP193095 | DCLK2 | 166614 | RNAseq | 0.7328 | 0.0020 | |
| SRP219564 | DCLK2 | 166614 | RNAseq | -0.9766 | 0.2463 | |
| TCGA | DCLK2 | 166614 | RNAseq | -1.0333 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DCLK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DCLK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DCLK2 | 166614 | 0 | 12 | 18 | |
| GSE20123 | DCLK2 | 166614 | 0 | 12 | 18 | |
| GSE43470 | DCLK2 | 166614 | 0 | 14 | 29 | |
| GSE46452 | DCLK2 | 166614 | 1 | 36 | 22 | |
| GSE47630 | DCLK2 | 166614 | 0 | 23 | 17 | |
| GSE54993 | DCLK2 | 166614 | 10 | 0 | 60 | |
| GSE54994 | DCLK2 | 166614 | 1 | 12 | 40 | |
| GSE60625 | DCLK2 | 166614 | 0 | 1 | 10 | |
| GSE74703 | DCLK2 | 166614 | 0 | 12 | 24 | |
| GSE74704 | DCLK2 | 166614 | 0 | 7 | 13 | |
| TCGA | DCLK2 | 166614 | 10 | 35 | 51 |
Total number of gains: 22; Total number of losses: 164; Total Number of normals: 302.
Somatic mutations of DCLK2:
Generating mutation plots.
Highly correlated genes for DCLK2:
Showing top 20/860 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DCLK2 | ADAMTSL1 | 0.775929 | 4 | 0 | 4 |
| DCLK2 | PPP1R14A | 0.748546 | 4 | 0 | 3 |
| DCLK2 | S1PR3 | 0.748259 | 3 | 0 | 3 |
| DCLK2 | HRC | 0.745173 | 4 | 0 | 4 |
| DCLK2 | ZSCAN18 | 0.741731 | 3 | 0 | 3 |
| DCLK2 | MEF2C-AS1 | 0.735827 | 3 | 0 | 3 |
| DCLK2 | EPHA7 | 0.732947 | 4 | 0 | 4 |
| DCLK2 | AQP1 | 0.723834 | 4 | 0 | 3 |
| DCLK2 | VIP | 0.722385 | 5 | 0 | 4 |
| DCLK2 | FILIP1 | 0.718031 | 4 | 0 | 4 |
| DCLK2 | ZBTB47 | 0.715409 | 3 | 0 | 3 |
| DCLK2 | MRVI1 | 0.709245 | 4 | 0 | 4 |
| DCLK2 | UBXN10 | 0.707285 | 4 | 0 | 4 |
| DCLK2 | CH25H | 0.707015 | 3 | 0 | 3 |
| DCLK2 | IQUB | 0.705736 | 4 | 0 | 3 |
| DCLK2 | NEGR1 | 0.705345 | 4 | 0 | 3 |
| DCLK2 | PLP1 | 0.700742 | 4 | 0 | 3 |
| DCLK2 | EPHA6 | 0.699766 | 3 | 0 | 3 |
| DCLK2 | RSPO3 | 0.6968 | 4 | 0 | 4 |
| DCLK2 | PRORY | 0.69601 | 3 | 0 | 3 |
For details and further investigation, click here
