| Full name: stearoyl-CoA desaturase 5 | Alias Symbol: ACOD4|FLJ21032|FADS4|HSCD5 | ||
| Type: protein-coding gene | Cytoband: 4q21.22 | ||
| Entrez ID: 79966 | HGNC ID: HGNC:21088 | Ensembl Gene: ENSG00000145284 | OMIM ID: 608370 |
| Drug and gene relationship at DGIdb | |||
SCD5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04152 | AMPK signaling pathway |
Expression of SCD5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCD5 | 79966 | 224901_at | 0.3135 | 0.7465 | |
| GSE20347 | SCD5 | 79966 | 220232_at | 0.3697 | 0.1881 | |
| GSE23400 | SCD5 | 79966 | 220232_at | 0.3323 | 0.0000 | |
| GSE26886 | SCD5 | 79966 | 224901_at | 2.1177 | 0.0000 | |
| GSE29001 | SCD5 | 79966 | 220232_at | 0.2275 | 0.2486 | |
| GSE38129 | SCD5 | 79966 | 220232_at | 0.0637 | 0.8897 | |
| GSE45670 | SCD5 | 79966 | 224901_at | 0.1877 | 0.6689 | |
| GSE53622 | SCD5 | 79966 | 40357 | 0.7592 | 0.0000 | |
| GSE53624 | SCD5 | 79966 | 74761 | 0.7004 | 0.0000 | |
| GSE63941 | SCD5 | 79966 | 224901_at | 0.1918 | 0.8155 | |
| GSE77861 | SCD5 | 79966 | 224901_at | 1.2921 | 0.0343 | |
| GSE97050 | SCD5 | 79966 | A_33_P3258660 | 0.0808 | 0.8073 | |
| SRP007169 | SCD5 | 79966 | RNAseq | 3.0404 | 0.0000 | |
| SRP008496 | SCD5 | 79966 | RNAseq | 2.5140 | 0.0000 | |
| SRP064894 | SCD5 | 79966 | RNAseq | 0.8871 | 0.0000 | |
| SRP133303 | SCD5 | 79966 | RNAseq | 0.5265 | 0.0115 | |
| SRP159526 | SCD5 | 79966 | RNAseq | 1.2210 | 0.0168 | |
| SRP193095 | SCD5 | 79966 | RNAseq | 0.5723 | 0.0000 | |
| SRP219564 | SCD5 | 79966 | RNAseq | 0.1242 | 0.7940 | |
| TCGA | SCD5 | 79966 | RNAseq | -0.1951 | 0.0629 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by SCD5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCD5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCD5 | 79966 | 2 | 11 | 17 | |
| GSE20123 | SCD5 | 79966 | 2 | 11 | 17 | |
| GSE43470 | SCD5 | 79966 | 0 | 13 | 30 | |
| GSE46452 | SCD5 | 79966 | 1 | 36 | 22 | |
| GSE47630 | SCD5 | 79966 | 0 | 20 | 20 | |
| GSE54993 | SCD5 | 79966 | 8 | 0 | 62 | |
| GSE54994 | SCD5 | 79966 | 1 | 9 | 43 | |
| GSE60625 | SCD5 | 79966 | 0 | 0 | 11 | |
| GSE74703 | SCD5 | 79966 | 0 | 11 | 25 | |
| GSE74704 | SCD5 | 79966 | 1 | 6 | 13 | |
| TCGA | SCD5 | 79966 | 12 | 34 | 50 |
Total number of gains: 27; Total number of losses: 151; Total Number of normals: 310.
Somatic mutations of SCD5:
Generating mutation plots.
Highly correlated genes for SCD5:
Showing top 20/228 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCD5 | ZNF611 | 0.759692 | 4 | 0 | 4 |
| SCD5 | ALMS1 | 0.7176 | 5 | 0 | 5 |
| SCD5 | FOLH1 | 0.709511 | 3 | 0 | 3 |
| SCD5 | CHD2 | 0.672801 | 3 | 0 | 3 |
| SCD5 | PRR11 | 0.666793 | 5 | 0 | 4 |
| SCD5 | ZNF160 | 0.660999 | 5 | 0 | 4 |
| SCD5 | SMCP | 0.658703 | 3 | 0 | 3 |
| SCD5 | ZNF639 | 0.653001 | 4 | 0 | 3 |
| SCD5 | INPP4A | 0.647357 | 5 | 0 | 3 |
| SCD5 | C11orf95 | 0.645694 | 5 | 0 | 4 |
| SCD5 | ANKRD10-IT1 | 0.644639 | 5 | 0 | 4 |
| SCD5 | PTPN14 | 0.643276 | 5 | 0 | 4 |
| SCD5 | CTBP2 | 0.636979 | 4 | 0 | 3 |
| SCD5 | RHOQ | 0.629742 | 4 | 0 | 4 |
| SCD5 | MARVELD1 | 0.627976 | 5 | 0 | 4 |
| SCD5 | CHST15 | 0.627175 | 6 | 0 | 5 |
| SCD5 | C15orf61 | 0.62573 | 4 | 0 | 3 |
| SCD5 | PTPRK | 0.62531 | 6 | 0 | 5 |
| SCD5 | AHI1 | 0.619687 | 3 | 0 | 3 |
| SCD5 | STK3 | 0.619543 | 5 | 0 | 3 |
For details and further investigation, click here
